Bacterial Lipids and Mechanisms Associated with Bacterial Resistance

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanisms and Structural Biology of Antibiotic Action".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 3303

Special Issue Editors


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Guest Editor
CNRS, University of Technology of Compiegne, 60203 Compiegne, France
Interests: Nuclear Magnetic Resonance (NMR); molecular interactions; membrane proteins
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Guest Editor
Faculté des Sciences et Technologies, UMR 8576 CNRS, Unité de Glycobiologie Structurale et Fonctionnelle, Cité Scientifique - Bât. C9, 59655 Villeneuve d'Ascq, France
Interests: lipidomic; glycomic; bacterial motility; adhesins

Special Issue Information

Dear Colleagues,

Bacterial lipid membranes are promising targets to fight antimicrobial resistance. A deep understanding of the membrane architecture is fundamental for the development of new efficient antimicrobial strategies. Emerging disciplines like lipidomics are extremely powerful, as they provide knowledge of the bacterial lipid composition and therefore could revitalize this long-standing area of research.

The goal of this Special Issue is to bring together current views, new insights, and cutting-edge research on the discovery and biological roles of bacteria and lipids (glycolipids, lipopolysaccharides, post-translational modifications, fatty acids...). These include bacterial lipid structures, lipid pathways, lipid role in bacterial physiology, lipid in biofilm formation, antibiotic resistance and lipids, lipid homeostasis in bacteria, stress response, bacterial interaction with host lipids, or immune evasion mechanisms.

We look forward to your contribution.

Dr. Luminita Duma
Dr. Yannick Rossez
Guest Editors

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Keywords

antimicrobial resistance

bacteria

lipids

membrane

biofilm

Published Papers (1 paper)

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Research

16 pages, 1556 KiB  
Article
Colistin Treatment Affects Lipid Composition of Acinetobacter baumannii
by Ye Tao, Sébastien Acket, Emma Beaumont, Henri Galez, Luminita Duma and Yannick Rossez
Antibiotics 2021, 10(5), 528; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10050528 - 03 May 2021
Cited by 12 | Viewed by 2727
Abstract
Multidrug-resistant Acinetobacter baumannii (A. baumannii) causes severe and often fatal healthcare-associated infections due partly to antibiotic resistance. There are no studies on A. baumannii lipidomics of susceptible and resistant strains grown at lethal and sublethal concentrations. Therefore, we analyzed the impact [...] Read more.
Multidrug-resistant Acinetobacter baumannii (A. baumannii) causes severe and often fatal healthcare-associated infections due partly to antibiotic resistance. There are no studies on A. baumannii lipidomics of susceptible and resistant strains grown at lethal and sublethal concentrations. Therefore, we analyzed the impact of colistin resistance on glycerolipids’ content by using untargeted lipidomics on clinical isolate. Nine lipid sub-classes were annotated, including phosphatidylcholine, rarely detected in the bacterial membrane among 130 different lipid species. The other lipid sub-classes detected are phosphatidylethanolamine (PE), phosphatidylglycerol (PG), lysophosphatidylethanolamine, hemibismonoacylglycerophosphate, cardiolipin, monolysocardiolipin, diacylglycerol, and triacylglycerol. Under lethal and sublethal concentrations of colistin, significant reduction of PE was observed on the resistant and susceptible strain, respectively. Palmitic acid percentage was higher at colistin at low concentration but only for the susceptible strain. When looking at individual lipid species, the most abundant PE and PG species (PE 34:1 and PG 34:1) are significantly upregulated when the susceptible and the resistant strains are cultivated with colistin. This is, to date, the most exhaustive lipidomics data compilation of A. baumannii cultivated in the presence of colistin. This work is highlighting the plasma membrane plasticity used by this gram-negative bacterium to survive colistin treatment. Full article
(This article belongs to the Special Issue Bacterial Lipids and Mechanisms Associated with Bacterial Resistance)
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