Special Issue "The Role of Efflux Pump Inhibitor in Bacterial Multidrug Resistance"
Deadline for manuscript submissions: closed (30 September 2021).
Interests: reversal of multidrug resistance in bacteria and cancer cells; efflux pump inhibitors; experimental chemotherapy
Special Issues and Collections in MDPI journals
Efflux pumps are protein constituents of all bacterial plasma membranes, and can recognize and extrude toxic compounds to the environment. The over-expression of these pumps is one of the hallmarks of the frequent failure of antimicrobial chemotherapy. For this reason the inhibition of efflux pumps could be an effective strategy to overcome multidrug resistance. Efflux pump inhibitors (EPIs) alone or in combination could restore the sensitivity of resistant strains by increasing the intracellular concentration of antibiotics and decreasing the level of intrinsic resistance. Concerning the chemical nature of EPIs, there are compounds from natural (plant) sources, semi-synthetic derivatives of existing EPIs, and fully synthetic EPIs as well.
This Special Issue of Antibiotics invites both reviews and original articles that consider efflux pump inhibitors as challenging tools to overcome multidrug resistance in bacteria.
Dr. Gabriella Spengler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- multidrug resistance
- multidrug efflux pump
- efflux pump inhibitor (EPI)
- accumulation assay
- efflux assay
- ethidium bromide
- quorum sensing