Special Issue "Bacterial Stress Responses and Antibiotic Resistance Phenotypes"
Deadline for manuscript submissions: 30 November 2021.
Interests: antibiotic resistance; AmpC beta-lactamases; heavy metal stress responses in bacteria; microbial functional genomics; Cedecea opportunistic pathogens
Bacteria employ exquisitely controlled stress response mechanisms to survive and adapt to a myriad of growth-compromising environmental insults, including cell envelope damage, nutrient deprivation, heavy metals, oxidative and nitrosative stress, and antimicrobial drug exposure. Growing research in this area continues to demonstrate a direct linkage between stress response systems and the development of antimicrobial resistance in bacteria. Stress response genes function as determinants of antibiotic resistance, and the induction of bacterial stress response systems plays important roles in the conversion of heterogeneous resistance phenotypes to high-level, homogeneous-resistance phenotypes. This interrelationship between stress and resistance is reinforced by evidence that the inactivation of stress response genes correlates with an increased susceptibility of bacteria to antibiotics. Additionally, random stress-induced mutations (adaptive mutagenesis) also affect antibiotic resistance in bacteria. Given that the global emergence of antibiotic resistance poses an increasing threat to the effective chemotherapeutic management of infectious diseases, the molecular components comprising adaptive cellular responses to stress are a potential valuable source of new targets for clinical intervention. This Special Issue of Antibiotics is seeking manuscript submissions that advance our understanding of the stress-related molecular determinants that contribute to the development of antibiotic resistance phenotypes in bacteria. Submissions providing insight into the mechanistic link between nutrient (stringent)/cell envelope/oxidative/nitrosative stress and antibiotic resistance in bacteria are particularly encouraged
Prof. Dr. Dorothea K. Thompson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Stress responses
- Stress-enhanced antibiotic resistance
- Stress determinants of antibiotic resistance phenotypes
- Nutrient stress
- Cell envelope stress
- Oxidative stress
- Nitrosative stress