Special Issue "Carbapenemase-Producing Enterobacterales"
Deadline for manuscript submissions: 31 December 2021.
Interests: antimicrobial resistance; carbapenemase; enterobacteriaceae; molecular typing; plasmid characterization; genetics; molecular biology; identification of vaccine candidates
The large family of Enterobacteriaceae includes such species as Klebsiella pneumoniae and Escherichia coli commonly responsible for healthcare infections. The increasing prevalence of resistance to antibiotics used to treat severe infections and diseases, in particular to carbapenems, is due to a rise in multidrug-resistant pathogens which pose an urgent threat to public health. Carbapenem-resistance is mainly associated with the production of carbapenemase—encoded by mobile genetic elements, which are usually plasmids that are horizontally acquired and highly transmissible. Carbapenem-resistant Enterobacteriaceae (CRE) are a common cause of infections in both community and healthcare settings. For this reason, the implementation of control measures and screening programs on CRE carriage is an important practical application toward limiting the dissemination of these strains between clinical wards. The focus of this Special Issue includes any aspects concerning plasmid-mediated antimicrobial resistance along with other carbapenem resistance mechanisms. Understanding the prevalence and routes of transmission of CRE is important in developing specific interventions for healthcare facilities. No less important is the general impact of CRE circulation on the environment. It is known that residues of antimicrobials that are widely used in clinical settings and also entering water and soil during intensive breeding create a selective pressure contributing to the increasing antibiotic resistance of microorganisms. In light of this, attention must be focused on carbapenemase testing in order to provide advanced phenotypic and molecular assays for the identification of CRE. Furthermore, the optimization of protocols could be a valid tool for active global surveillance, and from this perspective, the study of resistance mechanisms can provide significant support for the development of new and appropriate antimicrobial molecules. For all of these reasons, the phenomenon of carbapenem-resistance deserves more attention, for the sake of public health.
Dr. Francesca Andreoni
Manuscript Submission Information
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- Carbapenem resistant Enterobacteriaceae
- Active surveillance
- Infection control
- epidemilogy typing
- plasmid typing