Special Issue "Molecular Evolution and Pathogenicity of Methicillin-Resistant Staphylococcus aureus"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 15 December 2021.

Special Issue Editor

Prof. Kunyan Zhang
E-Mail Website
Guest Editor
1. Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, AB, Canada
2. Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, AB, Canada
3. Department of Medicine, University of Calgary, Calgary, AB, Canada
4. Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
5. Centre for Antimicrobial Resistance, Alberta Health Services (AHS), Calgary, AB, Canada
Interests: molecular diagnostics of clinical microbiology; microbial evolution and diversity; MRSA molecular epidemiology, virulence and pathogenesis; staphylococcal cassette chromosome mec (SCCmec)

Special Issue Information

Dear Colleagues,

Staphylococcus aureus is a gram positive and coagulase positive pathogen, belonging to the family of Staphylococcaceae. It has the capability to acquire resistance to most antibiotics and to collect virulence factors. This ability is further augmented by its constant emergence of new clones. Historically, penicillin-resistant S. aureus emerged in 1942 within two years of introduction of penicillin. Semi-synthetic antibiotic, methicillin, was then developed to substitute for the treament of penicillin-resistant S. aureus. However, methicillin-resistant S. aureus (MRSA) was clinically identified in 1960 shortly after its introduction in 1959. Thereafter, the worldwide outbreaks of MRSA occur in waves. The dissemination of MRSA is marked by the propagation of a number of clones harboring specific genetic backgrounds in different continents. Although most MRSA strains are hospital-acquired originally, community-associated strains (CA-MRSA) are now been increasingly recognised worldwide and are both phenotypically and genotypically different from hospital-associated (HA)-MRSA. The importance of Livestock-associated (LA)-MRSA has also been frequently reported sine the mid of 2000s. Infections due to MRSA, in particular CA-MRSA and LA-MRSA, are associated with more severity and higher mortality rate, compared to infections caused by methicillin-susceptible strains. This special issue seeks manuscript submissions in the latest advances in molecular evolution, epidemiology, characterization and pathogenicity of MRSA, as well as, its emerging trends in antibiotic resistance and control.

Prof. Kunyan Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Staphylococcus aureus
  • methicillin-susceptive S. aureus (MSSA)
  • methicillin-resistant S. aureus (MRSA)
  • hospital-associated MRSA (HA-MRSA)
  • community-associated MRSA (CA-MRSA)
  • livestock-associated MRSA (LA-MRSA)
  • molecular evolution, epidemiology, characterization and pathogenicity of MRSA
  • antibiotic resistance
  • infection prevention and control

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: SCCmec, Past, Now and Future
Author: Yuki Uehara
Department of Clinical Laboratory and Infectious Diseases, St. Luke's International Hospital, Tokyo Japan
Department of Microbiology, Juntendo University Faculty of Medicine, Tokyo, Japan
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