New Antibacterial Nanostructured Coatings for Biomedical Applications

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 11695

Special Issue Editor

Laboratorio di Patologia delle Infezioni Associate all’Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy
Interests: implant-associated infections; anti-infective substances and strategies; virulence factors; bacterial biofilm; bacterial molecular epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bacterial colonization on biomedical devices, together with the worrisome problem of antibiotic resistance, arouse interest in the development of anti-infective materials. Among the promising applications, engineered antibacterial nanostructured coatings represent an innovative perspective in the field of biomedical application. These nanostructured coatings can be mainly categorized into organic (e.g., liposomes, polymeric micelles and polymeric nanoparticles, lipid-based nanoparticles), which are implicated in drug delivery, and inorganic (e.g., ions), which cause free-radical stress in bacteria. Other approaches in combination with nanostructured coatings, such as antimicrobial peptides, antimicrobial oligonucleotides, and natural compounds, are encouraged. Indeed, modern medicine has rediscovered natural resources and relies on their different molecular backgrounds to recognize molecules with antimicrobial properties. These molecules could be used in nanocoating technologies for medical devices, for food nano-packaging, and in the green synthesis of nanoparticles.

Paper topics might include the following:

  • Biomaterials and new antibacterial agents and novel approaches with nanostructured coatings;
  • Biomedical applications and medical devices;
  • Green synthesis of nanoparticles/nanocoatings
  • Phytocompound-based nanostructured coatings;
  • Food nano-packaging;
  • New antimicrobials from natural sources;
  • Design and synthesis/realization of antibacterial nanomaterials;
  • Material and physicochemical characterization of the modified surfaces, functional properties, and performance in terms of enhanced adsorption, drug efficiency, and biodistribution;
  • Antibacterial activity studies;
  • Cytotoxicity assays in human cells and tissues.

Dr. Stefano Ravaioli
Guest Editor

Manuscript Submission Information

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Keywords

  • antibacterial nanostructured coatings
  • medical devices
  • biomaterials
  • physicochemical haracterization
  • antibacterial mechanisms
  • antibiofilm and antibacterial activity
  • cytotoxicity

Published Papers (3 papers)

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Research

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18 pages, 6347 KiB  
Article
Fabrication and Evaluation of Basil Essential Oil-Loaded Halloysite Nanotubes in Chitosan Nanocomposite Film and Its Application in Food Packaging
by Narayan Chaudhary, Gourav Mishra, Tushar Yadav, Nishant Srivastava, Vimal K. Maurya and Shailendra K. Saxena
Antibiotics 2022, 11(12), 1820; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics11121820 - 15 Dec 2022
Cited by 4 | Viewed by 2127
Abstract
Increasing health concerns regarding the use of plasticware have led to the development of ecofriendly biodegradable packaging film from natural polymer and food additives. In the present study, basil essential oil (BEO) loaded halloysite nanotubes (HNTs) composite films were synthesized using a solution [...] Read more.
Increasing health concerns regarding the use of plasticware have led to the development of ecofriendly biodegradable packaging film from natural polymer and food additives. In the present study, basil essential oil (BEO) loaded halloysite nanotubes (HNTs) composite films were synthesized using a solution casting method. The effects of BEO and nanotube concentration on the mechanical, physical, structural, barrier, and antioxidant properties of films were evaluated. Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) demonstrated well-dispersed HNTs and BEO in tailored composite films. The addition of BEO in Chitosan (Ch) film caused darkening of the film color; furthermore, the incorporation of HNTs in varied concentrations increased opaqueness in Ch/BEO film. The Ch/BEO film, upon adding HNTs 5–30 wt%, exhibited a corresponding increase in the film thickness (0.108–0.135 mm) when compared with the Ch/BEO film alone (0.081 mm). The BEO-loaded HNTs composite films displayed reduced moisture content and characteristic barrier and UV properties. The Ch/BEO film with 15 wt% HNTs was found to have enhanced antioxidant activity. The Ch/BEO/HNTs composite also managed to prevent broccoli florets from losing weight and firmness during storage. The enhanced barrier and antioxidant qualities of the nanocomposite film suggest its potential application in the food processing and packaging sector. This is the first ever report on the fabrication of nanocomposite film using BEO and HNTs for food packaging. The low production cost and ecofriendly approach make the film acceptable for further research and commercialization thereafter. Full article
(This article belongs to the Special Issue New Antibacterial Nanostructured Coatings for Biomedical Applications)
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17 pages, 1793 KiB  
Article
The Analysis of Chitosan-Coated Nanovesicles Containing Erythromycin—Characterization and Biocompatibility in Mice
by Loredana Nicoleta Hilițanu, Liliana Mititelu-Tarțău, Grațiela Eliza Popa, Beatrice Rozalina Buca, Liliana Lăcrămioara Pavel, Ana-Maria Pelin, Andreea-Daniela Meca, Maria Bogdan and Daniela Angelica Pricop
Antibiotics 2021, 10(12), 1471; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10121471 - 30 Nov 2021
Cited by 9 | Viewed by 1783
Abstract
Nanoantibiotics have proved improved pharmacokinetic characteristics and antimicrobial features. Recent studies have shown non-toxicity, non-immunogenicity, antioxidant, anti-hyperlipidemic, and hepatocyte protective actions, among other advantages of chitosan-based nanoparticles. The purpose of our study was the structural analysis of novel chitosan-coated vesicles entrapping erythromycin (ERT) [...] Read more.
Nanoantibiotics have proved improved pharmacokinetic characteristics and antimicrobial features. Recent studies have shown non-toxicity, non-immunogenicity, antioxidant, anti-hyperlipidemic, and hepatocyte protective actions, among other advantages of chitosan-based nanoparticles. The purpose of our study was the structural analysis of novel chitosan-coated vesicles entrapping erythromycin (ERT) and the assessment of their biocompatibility in mice. According to the group in which they were randomly assigned, the mice were treated orally with one of the following: distilled water; chitosan; ERT; chitosan vesicles containing ERT. Original nanosystems entrapping ERT in liposomes stabilized with chitosan were designed. Their oral administration did not produce sizeable modifications in the percentages of the leukocyte formula elements, of some blood constants useful for evaluating the hepatic and renal function, respectively, and of some markers of oxidative stress and immune system activity, which suggests a good biocompatibility in mice. The histological examination did not reveal significant alterations of liver and kidney architecture in mice treated with chitosan liposomes entrapping ERT. The results indicate the designed liposomes are a promising approach to overcome disadvantages of conventional ERT treatments and to amplify their benefits and can be further studied as carrier systems. Full article
(This article belongs to the Special Issue New Antibacterial Nanostructured Coatings for Biomedical Applications)
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Review

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22 pages, 1966 KiB  
Review
Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications
by Yaseen Hussain, Waqas Alam, Hammad Ullah, Marco Dacrema, Maria Daglia, Haroon Khan and Carla Renata Arciola
Antibiotics 2022, 11(3), 322; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics11030322 - 28 Feb 2022
Cited by 49 | Viewed by 6951
Abstract
Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of [...] Read more.
Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential. In combination therapy with other phytochemicals, curcumin shows synergistic effects, and this approach appears to be suitable for the eradication of antibiotic-resistant microbes and promising for achieving co-loaded antimicrobial pro-regenerative coatings for orthopedic implant biomaterials. Poor water solubility, low bioavailability, and rapid degradation are the main disadvantages of curcumin. The use of nanotechnologies for the delivery of curcumin could increase the prospects for its clinical application, mainly in orthopedics and other surgical scenarios. Curcumin-loaded nanoparticles revealed antimicrobial properties against S. aureus in periprosthetic joint infections. Full article
(This article belongs to the Special Issue New Antibacterial Nanostructured Coatings for Biomedical Applications)
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