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Antibiotics
Special Issues
Natural Antimicrobial Products from Plants and Fungi: Current Knowledge and...
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Natural Antimicrobial Products from Plants and Fungi: Current Knowledge and Future Prospects, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (16 December 2021) | Viewed by 5452

Special Issue Editors

Dr. Paola Angelini

E-Mail Website1 Website2
Guest Editor
Department of Chemistry, Biology, and Biotechnology, University of Perugia, 06122 Perugia, Italy
Interests: biodiversity; biological activities; dermatophyte; essential oils; medicinal Plants; mushrooms; non-volatile extracts
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Luigi Menghini

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Guest Editor
Department of Pharmacy, University “G.d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Interests: botanical and phytochemical characterization of medicinal plants and agricultural by-products
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Roberto Venanzoni

E-Mail Website
Guest Editor
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06121 Perugia, Italy
Interests: botany; vegatation science; biological activities; dermatophyte; plants; fungal extracts
Special Issues, Collections and Topics in MDPI journals
Dr. Giustino Orlando

E-Mail Website
Guest Editor
Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Interests: food compounds; bioactive extracts; inflammation; oxidative metabolic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants and fungi are rich sources of thousands of secondary metabolites, which consist of low-molecular weight compounds, e.g., terpenoids and steroids, fatty-acid-derived substances and polyketides, alkaloids, nonribosomal polypeptides, and shikimate-derived. These compounds exhibit different bioactivities, such as antibacterial, antifungal, and antiviral, with different mechanisms for killing pathogens.

The increased emergence of antimicrobial-resistant pathogens is a major healthcare problem worldwide. It is estimated that antimicrobial resistance contributes annually to approximately 700,000 deaths across the world.

Plants and fungi offer exceptional chemical diversity with a wide variety of biological activities and thus are the most promising sources for drug discovery and development.

The aim of this Special Issue is to present the status of and future trends in natural products from plants and fungi with antimicrobial properties (i.e., antibacterial, antifungal, antiviral). Other suitable topics are methods for increase in metabolite yield (e.g., bioelicitation) and investigation of genetic bases in metabolite production. Alternative use of plants and fungal compounds and extracts with antimicrobial activities in food, beverage, supplements, and cosmetic may also be part of this Special Issue.

The Special Issue may include research papers and reviews on the antimicrobial properties of extracts and/or new metabolites from plants and fungi, a dynamic field at the intersection of microbiology, biotechnology, pharmacology, and biology.

Dr. Paola Angelini
Prof. Dr. Luigi Menghini
Prof. Roberto Venanzoni
Prof. Dr. Giustino Orlando
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • biofilms
  • cytotoxicity
  • dermatophytosis
  • drug resistance
  • essential oils
  • mushrooms
  • non-volatile extracts
  • pathogenic bacteria
  • plants

Published Papers (2 papers)

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Research

10 pages, 1484 KiB  
Article
Hydroalcoholic Leaf Extract of Punica granatum, alone and in Combination with Calcium Hydroxide, Is Effective against Mono- and Polymicrobial Biofilms of Enterococcus faecalis and Candida albicans
by Monica Naufel Sousa, Alessandra Teixeira Macedo, Gabriella Freitas Ferreira, Haryne Lizandrey Azevedo Furtado, Aruanã Joaquim Matheus Costa Rodrigues Pinheiro, Lídio Gonçalves Lima-Neto, Valéria Costa Fontes, Rayana Larissa Pinheiro Soares Ferreira, Cristina Andrade Monteiro, Angela Falcai, Lillian Nunes Gomes, Queila da Silva Rosa Bragança, Dennyse de Sousa Brandão Torres, Lívia Câmara de Carvalho Galvão, Rodrigo Assuncao Holanda and Julliana Ribeiro Alves Santos
Antibiotics 2022, 11(5), 584; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics11050584 - 27 Apr 2022
Cited by 7 | Viewed by 1889
Abstract
Failures in endodontic treatments are mostly associated with the difficulty in eradicating microbes of the root canal system, highlighting the need to develop novel effective antimicrobials. Punica granatum (pomegranate) leaf hydroalcoholic extract may be a potential alternative in canal dressing, owing to its [...] Read more.
Failures in endodontic treatments are mostly associated with the difficulty in eradicating microbes of the root canal system, highlighting the need to develop novel effective antimicrobials. Punica granatum (pomegranate) leaf hydroalcoholic extract may be a potential alternative in canal dressing, owing to its antimicrobial properties. The objective of this study was to evaluate the antimicrobial activity of hydroalcoholic leaf extract of Punica granatum (HEPg) alone or in combination with calcium hydroxide (Ca(OH)2) against Enterococcus faecalis and Candida albicans in isolation and in mono- and polymicrobial biofilms. Microdilution tests in broth and assays for inhibition of biofilm formation were carried out to evaluate the antimicrobial properties of HEPg and HEPg + Ca(OH)2 against Enterococcus faecalis and Candida albicans. The cytotoxicity of HEPg in HaCaT cells was evaluated by MTT assay. HEPg and HEPg + Ca(OH)2 exerted significant antimicrobial activity against planktonic cells and mono- and polymicrobial biofilms. The combination of Punica granatum extract with Ca(OH)2 appears to be a promising alternative in endodontic treatments, which could be tested in vivo to confirm the efficacy of this mixture in disinfecting root canal systems. Full article
(This article belongs to the Special Issue Natural Antimicrobial Products from Plants and Fungi: Current Knowledge and Future Prospects, 2nd Edition)
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15 pages, 2837 KiB  
Article
Polyphenol-Rich Larix decidua Bark Extract with Antimicrobial Activity against Respiratory-Tract Pathogens: A Novel Bioactive Ingredient with Potential Pharmaceutical and Nutraceutical Applications
by Marta Faggian, Giulia Bernabè, Sara Ferrari, Stefano Francescato, Gianni Baratto, Ignazio Castagliuolo, Stefano Dall’Acqua and Gregorio Peron
Antibiotics 2021, 10(7), 789; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10070789 - 28 Jun 2021
Cited by 11 | Viewed by 2805
Abstract
Larch (Larix decidua) bark is a sawmill waste, traditionally used for antiseptic, expectorant and dermatological (wound healing, eczema, psoriasis) purposes. In this work, we developed a food-grade dry larch bark extract (LBE) from sawmill by-products using hydro-alcoholic extraction. The antibacterial activity [...] Read more.
Larch (Larix decidua) bark is a sawmill waste, traditionally used for antiseptic, expectorant and dermatological (wound healing, eczema, psoriasis) purposes. In this work, we developed a food-grade dry larch bark extract (LBE) from sawmill by-products using hydro-alcoholic extraction. The antibacterial activity of LBE was evaluated against respiratory-tract pathogens, i.e., Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Klebsiella pneumoniae, Pseudomonas aeruginosa and Haemophilus influenza, and it was compared to that of grapefruit seed extract (GSE), a commercially available raw material commonly proposed as antibacterial ingredient for over-the-counter products. Procyanidins (PACs) and other polyphenols contents in LBE were determined by HPLC-FLD-MS and HPLC-DAD-MSn, respectively. The antimicrobial activity of LBE and GSE was assessed using the micro-plate dilution technique in concentration range of 2–200 µg/mL, and the safety of these dosages was assessed in cellular and animal models. LBE showed considerable contents of PACs (15% w/w; especially B-type) and other polyphenols (3.8% w/w), among which the characteristic spiropolyphenols larixinol and epilarixinol were identified, together with the flavonoids isoquercitrin and rutin, already reported as growth inhibitors of different respiratory-tract pathogens. LBE showed higher antimicrobial activity compared to GSE, demonstrated by a growth inhibition range of 10–40% towards five of six strains tested, compared to 10–15% of GSE. These results suggest that LBE may represent a natural and sustainable source of active compounds with antibacterial activity for pharmaceutical and nutraceutical applications. Full article
(This article belongs to the Special Issue Natural Antimicrobial Products from Plants and Fungi: Current Knowledge and Future Prospects, 2nd Edition)
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