Special Issue "Natural Antimicrobial Products from Plants and Fungi: Current Knowledge and Future Prospects, 2nd Edition"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 16 December 2021.

Special Issue Editors

Dr. Paola Angelini
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Guest Editor
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06121 Perugia, Italy
Interests: biodiversity; biological activities; dermatophyte; essential oils; medicinal plants; mushrooms; non-volatile extracts
Special Issues and Collections in MDPI journals
Prof. Dr. Luigi Menghini
E-Mail Website
Guest Editor
Prof. Roberto Venanzoni
E-Mail Website
Guest Editor
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06121 Perugia, Italy
Interests: botany; vegatation science; biological activities; dermatophyte; plants and fungal extracts
Special Issues and Collections in MDPI journals
Prof. Dr. Giustino Orlando
E-Mail Website
Guest Editor
Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Interests: pharma-toxicological evaluation of medicinal plant; herbal extract activity
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Plants and fungi are rich sources of thousands of secondary metabolites, which consist of low-molecular weight compounds, e.g., terpenoids and steroids, fatty-acid-derived substances and polyketides, alkaloids, nonribosomal polypeptides, and shikimate-derived. These compounds exhibit different bioactivities, such as antibacterial, antifungal, and antiviral, with different mechanisms for killing pathogens.

The increased emergence of antimicrobial-resistant pathogens is a major healthcare problem worldwide. It is estimated that antimicrobial resistance contributes annually to approximately 700,000 deaths across the world.

Plants and fungi offer exceptional chemical diversity with a wide variety of biological activities and thus are the most promising sources for drug discovery and development.

The aim of this Special Issue is to present the status of and future trends in natural products from plants and fungi with antimicrobial properties (i.e., antibacterial, antifungal, antiviral). Other suitable topics are methods for increase in metabolite yield (e.g., bioelicitation) and investigation of genetic bases in metabolite production. Alternative use of plants and fungal compounds and extracts with antimicrobial activities in food, beverage, supplements, and cosmetic may also be part of this Special Issue.

The Special Issue may include research papers and reviews on the antimicrobial properties of extracts and/or new metabolites from plants and fungi, a dynamic field at the intersection of microbiology, biotechnology, pharmacology, and biology.

Dr. Paola Angelini
Prof. Dr. Luigi Menghini
Prof. Roberto Venanzoni
Prof. Dr. Giustino Orlando
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • biofilms
  • cytotoxicity
  • dermatophytosis
  • drug resistance
  • essential oils
  • mushrooms
  • non-volatile extracts
  • pathogenic bacteria
  • plants

Published Papers (1 paper)

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Research

Article
Polyphenol-Rich Larix decidua Bark Extract with Antimicrobial Activity against Respiratory-Tract Pathogens: A Novel Bioactive Ingredient with Potential Pharmaceutical and Nutraceutical Applications
Antibiotics 2021, 10(7), 789; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10070789 - 28 Jun 2021
Viewed by 351
Abstract
Larch (Larix decidua) bark is a sawmill waste, traditionally used for antiseptic, expectorant and dermatological (wound healing, eczema, psoriasis) purposes. In this work, we developed a food-grade dry larch bark extract (LBE) from sawmill by-products using hydro-alcoholic extraction. The antibacterial activity [...] Read more.
Larch (Larix decidua) bark is a sawmill waste, traditionally used for antiseptic, expectorant and dermatological (wound healing, eczema, psoriasis) purposes. In this work, we developed a food-grade dry larch bark extract (LBE) from sawmill by-products using hydro-alcoholic extraction. The antibacterial activity of LBE was evaluated against respiratory-tract pathogens, i.e., Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Klebsiella pneumoniae, Pseudomonas aeruginosa and Haemophilus influenza, and it was compared to that of grapefruit seed extract (GSE), a commercially available raw material commonly proposed as antibacterial ingredient for over-the-counter products. Procyanidins (PACs) and other polyphenols contents in LBE were determined by HPLC-FLD-MS and HPLC-DAD-MSn, respectively. The antimicrobial activity of LBE and GSE was assessed using the micro-plate dilution technique in concentration range of 2–200 µg/mL, and the safety of these dosages was assessed in cellular and animal models. LBE showed considerable contents of PACs (15% w/w; especially B-type) and other polyphenols (3.8% w/w), among which the characteristic spiropolyphenols larixinol and epilarixinol were identified, together with the flavonoids isoquercitrin and rutin, already reported as growth inhibitors of different respiratory-tract pathogens. LBE showed higher antimicrobial activity compared to GSE, demonstrated by a growth inhibition range of 10–40% towards five of six strains tested, compared to 10–15% of GSE. These results suggest that LBE may represent a natural and sustainable source of active compounds with antibacterial activity for pharmaceutical and nutraceutical applications. Full article
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