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Antibiotics
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Antibacterial Activity of Plant Extracts and Essential Oils - 2nd...
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Antibacterial Activity of Plant Extracts and Essential Oils - 2nd Volume

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (10 May 2022) | Viewed by 13479

Special Issue Editors

Prof. Dr. Fernanda Domingues

E-Mail Website
Guest Editor
CICS-UBI Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal
Interests: antimicrobial resistance; bioactive compounds; antimicrobial activity; mechanisms of action; food packaging
Dr. Ângelo Luís

E-Mail Website
Guest Editor
CICS-UBI Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal
Interests: plant extracts; essential oils; polyphenols; antioxidant and antimicrobial properties; functional films
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

After the great success of the First Volume of this Special Issue, it is our great pleasure to announce the Second Volume.

The ample exploit of antibiotics in the management of bacterial infections has led to the emergence and multiplication of resistant bacterial strains. Infections due to multidrug-resistant pathogens are routinely complicated by virulence factors coupled with a relatively limited choice of antimicrobial agents. Thus, it is extremely important to find novel antimicrobials or new techniques that are effective in treating infectious diseases caused by drug-resistant microorganisms. Furthermore, microorganisms have a natural capacity to attach to surfaces, multiply, embed themselves in a slimy matrix, and form biofilms, making their eradication more difficult and complex.

Throughout the history of mankind, many infectious diseases have been treated with herbal remedies. Even today, plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries.

This Special Issue aims to publish high-quality manuscripts evaluating the antibacterial properties of plant extracts and essential oils together with their chemical characterization, bioassay-guided fractionation, isolation, and/or structure elucidation. Moreover, studies regarding the anti-biofilm activity and/or the inhibition of quorum sensing mechanisms by plant extracts and essential oils will be highlighted. Emergent approaches incorporating natural bioactive compounds to control microbial growth are also of interest. Finally, systematic reviews and meta-analyses dealing with the antibacterial properties of plant materials will be welcomed.

Prof. Dr. Fernanda Domingues
Dr. Ângelo Luís
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antibacterial activity
  • Plant extracts
  • Essential oils
  • Phytochemicals
  • Biofilms
  • Synergistic interactions
  • Quorum sensing
  • Functional films
  • Meta-analysis

Published Papers (4 papers)

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Research

16 pages, 3228 KiB  
Article
Effect of Essential Oils on Growth Inhibition, Biofilm Formation and Membrane Integrity of Escherichia coli and Staphylococcus aureus
by Andrés Martínez, Marcela Manrique-Moreno, Maria C. Klaiss-Luna, Elena Stashenko, German Zafra and Claudia Ortiz
Antibiotics 2021, 10(12), 1474; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10121474 - 30 Nov 2021
Cited by 21 | Viewed by 3894
Abstract
Biofilm as a cellular conformation confers survival properties to microbial populations and favors microbial resistance. Here, we investigated the antimicrobial, antibiofilm, antimotility, antihemolytic activity, and the interaction with synthetic membranes of 15 essential oils (EOs) on E. coli ATCC 25922 and S. aureus [...] Read more.
Biofilm as a cellular conformation confers survival properties to microbial populations and favors microbial resistance. Here, we investigated the antimicrobial, antibiofilm, antimotility, antihemolytic activity, and the interaction with synthetic membranes of 15 essential oils (EOs) on E. coli ATCC 25922 and S. aureus ATCC 29213. Antimicrobial activity of EOs was determined through microdilution method; development of the biofilm was assessed using the crystal violet assay and SEM microscopy. Results indicate that Lippia origanoides thymol–carvacrol II chemotype (LTC II) and Thymus vulgaris (TV) exhibited a significant antibacterial activity, with MIC values of 0.45 and 0.75 mg/mL, respectively. The percentage of biofilm formation inhibition was greater than 70% at subinhibitory concentrations (MIC50) for LTC II EO. The results demonstrate that these two oils had significantly reduced the hemolytic effect of S. aureus by 54% and 32%, respectively, and the mobility capacity by swimming in E. coli with percentages of decrease of 55% and 47%, respectively. The results show that LTC II and TV EOs can interact with the hydrophobic core of lipid bilayers and alter the physicochemical properties of membranes. The findings suggest that LTC II and TV oils may potentially be used to aid in the treatment of S. aureus and E. coli infections. Full article
(This article belongs to the Special Issue Antibacterial Activity of Plant Extracts and Essential Oils - 2nd Volume)
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13 pages, 1375 KiB  
Article
Alternative and Complementary Therapies against Foodborne Salmonella Infections
by Mohamed F. Ghaly, Zahraa M. Nasr, Amira I. Abousaty, Hanan G. Seadawy, Mohamed A. A. Shaheen, Sarah Albogami, Mohammad M. Al-Sanea and Mahmoud M. Bendary
Antibiotics 2021, 10(12), 1453; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10121453 - 26 Nov 2021
Cited by 13 | Viewed by 2471
Abstract
The limitations in the therapeutic options for foodborne pathogens lead to treatments failure, especially for multidrug-resistant (MDR) Salmonella sp., worldwide. Therefore, we aimed to find alternative and complementary therapies against these resistant foodborne pathogens. Out of 100 meat products samples, the prevalence rate [...] Read more.
The limitations in the therapeutic options for foodborne pathogens lead to treatments failure, especially for multidrug-resistant (MDR) Salmonella sp., worldwide. Therefore, we aimed to find alternative and complementary therapies against these resistant foodborne pathogens. Out of 100 meat products samples, the prevalence rate of salmonella was 6%, serotyped only as S. Typhimurium and S. Enteritidis. According to the antibiotic susceptibility assays, the majority of our isolates were MDR and susceptible to cefotaxime. Out of the 13 tested plant extracts, five only showed an inhibition zone in the range of 8–50 mm against both serotypes. Based on their promising activity, the oily extract of cinnamon and aqueous extract of paprika represented the highest potency. Surprisingly, a significant synergistic effect was detected between cinnamon oil and cefotaxime. Depending on Gas Chromatography/Mass Spectrometry (GC-MS), the antimicrobial activity of cinnamon oil was attributed to four components including linalool, camphor, (Z)-3-Phenylacrylaldehyde and its stereoisomer 2-Propenal-3-phenyl. The anti-virulence activities of these compounds were confirmed on the basis of computational molecular docking studies. Accordingly, we recommended the use of cinnamon oil as a food additive to fight the resistant foodborne pathogens. Additionally, we confirmed its therapeutic uses, especially when co-administrated with other antimicrobial agents. Full article
(This article belongs to the Special Issue Antibacterial Activity of Plant Extracts and Essential Oils - 2nd Volume)
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12 pages, 1217 KiB  
Communication
Screening of the Potential Bioactivities of Pennyroyal (Mentha pulegium L.) Essential Oil
by Ângelo Luís and Fernanda Domingues
Antibiotics 2021, 10(10), 1266; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10101266 - 18 Oct 2021
Cited by 8 | Viewed by 2367
Abstract
Increasing resistance of pathogens towards conventional antibiotics presents a major threat to public health because it reduces the effectiveness of antibiotic treatment. Mentha pulegium L., also known as pennyroyal, is an aromatic herb that belongs to the family Lamiaceae. Its essential oil has [...] Read more.
Increasing resistance of pathogens towards conventional antibiotics presents a major threat to public health because it reduces the effectiveness of antibiotic treatment. Mentha pulegium L., also known as pennyroyal, is an aromatic herb that belongs to the family Lamiaceae. Its essential oil has been traditionally used in medicine, aromatherapy, and cosmetics. The purpose of this work was to study the chemical composition of a pennyroyal essential oil and to evaluate their bioactivities, specifically, antioxidant, antimicrobial, anti-quorum sensing, and anti-inflammatory. A special focus was given to the antibacterial activity of the essential oil against Acinetobacter baumannii. The chemical composition of the essential oil was studied by GC-MS/GC-FID. The DPPH free radical scavenging assay and the β-carotene/linoleic acid system were used to evaluate the antioxidant properties. The antimicrobial and anti-quorum sensing activities were evaluated by disk diffusion assays and complemented with optical microscopy observations. The results showed that pulegone was the major compound (88.64%) of the pennyroyal essential oil. Regarding the antimicrobial activity, the action against Acinetobacter baumannii stands out, which, together with the capacity of the essential oil to inhibit the quorum sensing mechanisms, may suggest the use of the pennyroyal essential oil to further develop surface disinfectants for hospitals. Full article
(This article belongs to the Special Issue Antibacterial Activity of Plant Extracts and Essential Oils - 2nd Volume)
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17 pages, 2236 KiB  
Article
HPLC-PDA-ESI-MS/MS Profiling and Anti-Biofilm Potential of Eucalyptussideroxylon Flowers
by Mona M. Okba, Riham A. El-Shiekh, Mohammed Abu-Elghait, Mansour Sobeh and Rehab M. S. Ashour
Antibiotics 2021, 10(7), 761; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10070761 - 23 Jun 2021
Cited by 20 | Viewed by 2994
Abstract
The development of multidrug-resistant bacterial strains is a worldwide emerging problem that needs a global solution. Exploring new natural antibiofilm agents is one of the most important alternative therapies in combating bacterial infections. This study aimed at testing the antimicrobial potential of Eucalyptus [...] Read more.
The development of multidrug-resistant bacterial strains is a worldwide emerging problem that needs a global solution. Exploring new natural antibiofilm agents is one of the most important alternative therapies in combating bacterial infections. This study aimed at testing the antimicrobial potential of Eucalyptus sideroxylon flowers extract (ESFE) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans prior to testing the antibiofilm activity against S. aureus, P. aeruginosa and C. albicans. ESFE demonstrated antimicrobial activity and promising inhibition activity against methicillin-resistant S. aureus (MRSA) biofilm formation up to 95.9% (p < 0.05) at a concentration of 0.05 mg/mL and eradicated C. albicans biofilm formation up to 71.2% (p < 0.05) at a concentration of 0.7 mg/mL. LC-MS analysis allowed the tentative identification of eighty-three secondary metabolites: 21 phloroglucinol, 18 terpenes, 16 flavonoids, 7 oleuropeic acid derivatives, 7 ellagic acid derivatives, 6 gallic acid derivatives, 3 phenolic acids, 3 fatty acids and 2 miscellaneous. In conclusion, E. sideroxylon is a rich source of effective constituents that promote its valorization as a promising candidate in the management of multidrug-resistant bacterial infections. Full article
(This article belongs to the Special Issue Antibacterial Activity of Plant Extracts and Essential Oils - 2nd Volume)
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