Special Issue "Antimicrobial Properties of Phytocomplexes and Isolated Compounds"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Matteo Micucci
E-Mail Website
Guest Editor
Alma Mater Studiorum Università di Bologna, Bologna, Italy
Interests: natural compounds; phytocomplexes; polyphenols; flavonoids; tannins; coumarins; stilbenes; phytosterols; antibacterial; multitarget; nutraceuticals

Special Issue Information

Dear Colleagues,

Infectious diseases are a global burden that has been worsening in recent years due to the development of species resistant to multiple antibiotics. Therefore, the identification of antimicrobial agents of high potency which are active against MDR microorganisms is fundamental to overcome this issue. 

Several plants and plant extracts have a long history of human usage in many countries for the treatment of pathologies due to infections, and they may represent important sources of active molecules with a great therapeutic potential and lesser side effects than conventional antibiotics.

Phytocomplexes’ antimicrobial activity often result from several molecules acting in synergy, and the clinical effects may be due to direct effects against microorganisms and indirect effects on the host immune system. When the phytocomplex has a direct strong antimicrobial activity that is not maintained with any of the isolated compounds, it should be considered for nutraceutical purposes. In the other cases, the medicinal plant may provide novel drug leads with antimicrobial activity.

Accordingly, it is desirable to promote scientific research where modern methods are applied to herbal medicines to identify phytocomplexes and isolated compounds which are active against MDR microorganisms, and molecular mechanisms should be defined.

This Special Issue is gathering manuscript submissions to increase the knowledge about the effects of phytocomplexes against microorganisms and to augment the number of leads that may be further studied in order to obtain new antibiotics which are also active against MDR microorganisms.

Submissions of studies about the antimicrobial effects of phytocomplexes and isolated compounds, where the possible synergistic effects of natural compounds with conventional antibiotics are also investigated, are most welcome.

Dr. Matteo Micucci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MDR
  • antibiotics
  • phytocomplex
  • isolated compounds
  • polyphenols
  • tannins
  • flavonoids
  • coumarins
  • terpenes
  • alkaloids
  • antimicrobial
  • nutraceuticals
  • multitarget

Published Papers (2 papers)

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Research

Article
Protective Effect of Grape (Vitis vinifera) Seed Powder and Zinc-Glycine Complex on Growth Traits and Gut Health of Broilers Following Eimeria tenella Challenge
Antibiotics 2021, 10(2), 186; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020186 - 14 Feb 2021
Viewed by 814
Abstract
The current study was conducted to evaluate the impact of grape (Vitis vinifera) seed powder and zinc-glycine complex on growth parameters and cecal health of broiler following Eimeria tenella challenge. A total of 250 day-old male broilers (Hubbard) were distributed into [...] Read more.
The current study was conducted to evaluate the impact of grape (Vitis vinifera) seed powder and zinc-glycine complex on growth parameters and cecal health of broiler following Eimeria tenella challenge. A total of 250 day-old male broilers (Hubbard) were distributed into five treatments as follows: I—negative control (basal diet); II—positive control (E. tenella challenge); III—group infected + Amprolium; IV—group coccidial infection + organic zinc (OZ) at 50 ppm + grape seed powder (GSP) at 2.5 g/kg; V—coccidial infection + organic zinc (OZ) at 50 ppm + grape seed powder (GSP) at 5.0 g/kg. From findings, a lower (p < 0.05) feed intake was noted for positive control compared to the other treatment groups. Conversely, higher (p < 0.05) body weight, dressing percentage, and feed conversion ratio were observed in infected + Amprolium, GSP2.5 + OZ50, and GSP5 + OZ50 treatments in comparison to the positive control. Moreover, the positive control showed severe cecal lesions of thickness and hemorrhages with mild congestion. The lesion scores decreased (p < 0.05) in GSP and OZ treated groups compared to the positive control. Significant (p < 0.05) lower oocyst per gram of feces was found in infected + Amprolium, GSP2.5 + OZ50, and GSP5 + OZ50 in comparison to positive control. Supplementing diet with GSP and OZ at both levels showed restoration of intense sloughing of villi. From the present findings, it can be concluded that OZ and grape seed powder positively ameliorated the growth performance, lesion score, and oocysts shedding in broilers infected with E. tenella. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Phytocomplexes and Isolated Compounds)
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Article
Phytocomplex Influences Antimicrobial and Health Properties of Concentrated Glycerine Macerates
Antibiotics 2020, 9(12), 858; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9120858 - 01 Dec 2020
Viewed by 534
Abstract
The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway [...] Read more.
The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway diseases. C-GMs of Carpinus betulus (CB), Ficus carica (FC), Alnus glutinosa (AG) and Ribes nigrum (RN) were studied. The quality was evaluated using HPLC and IM-SPME/GC-MS systems; anti-oxidant and anti-microbial activities were assessed by the respective DPPH test, and micro-broth dilution test performed against 10 strains of Streptococcus pyogenes and 10 probiotic strains. ELISA and MTT tests were used to assess the immunomodulatory activity and the cytotoxicity of C-GMs, respectively. A significant correlation was found between the number of active compounds and the in vitro C-GMs effectiveness. Furthermore, the C-GMs of AG showed the best anti-microbial activity on pathological strains and, together with CB, the best anti-oxidant activity. The ELISA test exhibited a good immunomodulatory activity of RN. In vitro data support the integrated use of C-GMs of CB, AG, and RN in presence of airway diseases, and highlight the importance of standard procedures in cultivation, harvest and post-harvest treatments, as a premise for C-GMs with consistent characteristics. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Phytocomplexes and Isolated Compounds)
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