Antibiotic Transport in Gram-Negative Bacteria
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanisms and Structural Biology of Antibiotic Action".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 4186
Special Issue Editor
Interests: transport phenomena; numerical simulations; molecular dynamics; molecular modelling; rare events; ion channels; nanopores; siderophores transporters; small-molecules transport; antibiotics permeation
Special Issue Information
Dear Colleagues,
Gram-negative bacteria have been classified from the WHO as the most critical priorities for the search of new anti-infectives. The pharmacological targets in Gram-negative bacteria are difficult to address. Though modern sequencing techniques have given access to innumerable potential new targets, the molecules identified with high-throughput screening campaigns are not able to be effective against bacteria in vivo. The singularity of Gram-negative species is a complex cell wall composed by an additional tick outer membrane with asymmetric composition. The outer membrane and its constituents (porins, specific transporters, and efflux pumps) are able to modulate the transport of molecules in and out, representing a complex filtering system for any molecule. Understanding the permeation of molecules in Gram-negative bacteria and their internal accumulation represents a scientific challenge for modern science and a boost to revitalize the early drug discovery phase. This Special Issue seeks manuscript submissions that further our understanding of molecular transport and eventually accumulation in Gram-negative species, in terms of structures involved an their mechanism of functioning, as well as with methods to measure accumulations and predictive tools
Dr. Matteo Ceccarelli
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bacterial porins
- active transporters
- siderophores
- efflux pumps
- outer membrane
- accumulation
- permeation
- kinetics
- predictive models
