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Antibiotics
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Antimicrobial Material in Dentistry
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Antimicrobial Material in Dentistry

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 5449

Special Issue Editor

Dr. Belén Cabal

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Guest Editor
Nanomaterials and Nanotechnology Research Center, Spanish National Research Council (CSIC)-Universidad de Oviedo-Principado de Asturias, El Entrego, Spain
Interests: antimicrobial materials; bioactive glasses; antimicrobial glass-ceramics; nanoparticles; biomaterials

Special Issue Information

Dear Colleagues,

Effective management of oral infectious diseases is a global challenge. Bacteria and biofilm formation on dental hard or soft tissue are the major cause of dental diseases (caries, periodontal and endodontic diseases). A wide variety of dental materials is used in the oral environment for restorative, prosthetic, and implant applications. However, none of these treatments guarantee complete elimination of bacteria/biofilm, nor the prevention of secondary infections. In order to achieve long-term clinical success, it is important to render dental materials with antimicrobial properties. Constant research is needed to continue improving the performance of these materials in dental practice.

The goal of this Special Issue is to provide an overview of the progressions in antimicrobial dental materials and the development of new strategies (not only based on antibiotics) for the prevention of biofilm formation, or for the treatment of dental materials associated infections. All types of articles falling within the scope of the above research areas are welcome.

Dr. Belén Cabal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endodontic
  • resin
  • dental implants
  • oral infection
  • antimicrobial
  • bactericidal
  • dental materials associated infections

Published Papers (2 papers)

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Research

14 pages, 44713 KiB  
Article
Adding Two Antimicrobial Glasses to an Endodontic Sealer to Prevent Bacterial Root Canal Reinfection: An In Vivo Pilot Study in Dogs
by Álvaro Zubizarreta-Macho, Cristina Rico-Romano, María Jesús Fernández-Aceñero, Jesús Mena-Álvarez, Belén Cabal, Luis Antonio Díaz, Ramón Torrecillas, José Serafín Moya and Roberto López-Píriz
Antibiotics 2021, 10(10), 1183; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10101183 - 28 Sep 2021
Cited by 1 | Viewed by 1922
Abstract
Current endodontic procedures continue to be unsuccessful for completely removing pathogens present inside the root canal system, which can lead to recurrent infections. In this study, we aimed to assess the antimicrobial capacity and tissue response of two inorganic bactericidal additives incorporated into [...] Read more.
Current endodontic procedures continue to be unsuccessful for completely removing pathogens present inside the root canal system, which can lead to recurrent infections. In this study, we aimed to assess the antimicrobial capacity and tissue response of two inorganic bactericidal additives incorporated into a paste root canal sealer on contaminated root dentin in vivo. An experimental study was performed in 30 teeth of five Beagle dogs. After inducing microbiological contamination, root canal systems were treated by randomly incorporating one of two antimicrobial additives into a commercial epoxy-amine resin sealer (AH Plus), i.e., G3T glass-ceramic (n = 10) and ZnO-enriched glass (n = 10); 10 samples were randomized as a control group. After having sacrificed the animals, microbiological, radiological, and histological analyses were performed, which were complemented with an in vitro bactericidal test and characterization by field emission scanning electron microscopy. The tested groups demonstrated a non-significant microbiological reduction in the postmortem periapical index values between the control group and the bactericidal glass-ceramic group (p = 0.885), and between the control group and the ZnO-enriched glass group (p = 0.169). The histological results showed low values of inflammatory infiltrate, and a healing pattern characterized by fibrosis in 44.4% of the G3T glass-ceramic and 60.0% of ZnO-enriched glass. Bactericidal glassy additives incorporated in this root canal sealer are safe and effective in bacterial reduction. Full article
(This article belongs to the Special Issue Antimicrobial Material in Dentistry)
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12 pages, 3169 KiB  
Article
Effect of Antibacterial Root Canal Sealer on Persistent Apical Periodontitis
by Zheng Wang, Ge Yang, Biao Ren, Yuan Gao, Xian Peng, Mingyun Li, Hockin H.K.Xu, Qi Han, Jiyao Li, Xuedong Zhou and Lei Cheng
Antibiotics 2021, 10(6), 741; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10060741 - 18 Jun 2021
Cited by 11 | Viewed by 2418
Abstract
The infection of Enterococcus faecalis and its interacting microorganisms in the root canal could cause persistent apical periodontitis (AP). Antibacterial root canal sealer has favorable prospects to inhibit biofilms. The purpose of this study was to investigated the antibacterial effect of root canal [...] Read more.
The infection of Enterococcus faecalis and its interacting microorganisms in the root canal could cause persistent apical periodontitis (AP). Antibacterial root canal sealer has favorable prospects to inhibit biofilms. The purpose of this study was to investigated the antibacterial effect of root canal sealer containing dimethylaminododecyl methacrylate (DMADDM) on persistent AP in beagle dogs for the first time. Persistent AP was established by a two-step infection with Enterococcus faecalis and multi-bacteria (Enterococcus faecalis, Lactobacillus acidophilus, Actinomycesnaeslundii, Streptococcus gordonii). Root canal sealer containing DMADDM (0%, 1.25%, 2.5%) was used to complete root canal filling. The volume of lesions and inflammatory grade in the apical area were evaluated by cone beam computer tomography (CBCT) and hematoxylin-eosin staining. Both Enterococcus-faecalis- and multi-bacteria-induced persistent AP caused severe apical destruction, and there were no significant differences in pathogenicity between them. DMADDM-modified sealer significantly reduced the volume of periapical lesion and inflammatory grade compared with the control group, among them, the therapeutic effect of the 2.5% group was better than the 1.25% group. In addition, E.faecalis-induced reinfection was more sensitive to the 2.5% group than multi-bacteria reinfection. This study shows that root canal sealer containing DMADDM had a remarkable therapeutic effect on persistent AP, especially on E. faecalis-induced reinfection. Full article
(This article belongs to the Special Issue Antimicrobial Material in Dentistry)
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