Special Issue "Bacterial Metabolic Reprograming and Antibiotic Susceptibility during Infection"
Deadline for manuscript submissions: closed (31 May 2020).
Interests: Pseudomonas; central carbon metabolism; biosynthesis; antibiotic targets; natural products; antibiotic resistance; antimicrobial development; host responses to bacterial infection
Many notable bacterial pathogens, such as Pseudomonas aeruginosa, Mycobacterium tuberculosis and Staphylococcus aureus display intrinsic resistance to many antibiotics or are known to rapidly acquire genetic mutations for further resistance, limiting treatment options.
Recent work has shown that antibiotic resistance in bacteria is regularly coupled with specific modifications in microbial metabolism. This metabolic reprogramming includes alterations in the electron transport chain, carbon flux and in the metabolism of amino acids, fatty acids or nucleotides. Indeed, the metabolic state of a bacterial population is known to be a strong determinant of antibiotic susceptibility. Understanding how the metabolic regulation of antibiotic susceptibility is orchestrated in bacteria may be the key to developing new antimicrobial strategies.
In this special issue, we will focus on the link between bacterial metabolism and antibiotic susceptibility during infection. Potential topics for primary research manuscripts and review articles include (but are not limited to) antimicrobials targeting core metabolic processes, mechanisms of antibiotic resistance, studies describing how bacterial metabolism responds to antibiotic exposure and how the host environment during infection constrains bacterial metabolism.
Dr. Stephen Dolan
Dr. Michael Kohlstedt
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Bacterial metabolism
- central carbon metabolism
- bacterial physiology