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4.8
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Antibiotics
Special Issues
Novel Peptides against Pathogenic Cells
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Novel Peptides against Pathogenic Cells

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 7983

Special Issue Editor

Dr. Jung Ro Lee

E-Mail Website
Guest Editor
National Institute of Ecology, Seocheon, Korea
Interests: antimicrobial mechanism; antibiotic drug discovery; biochemical and genetic study of plant defense system; redox regulation; Genetically Modified Organism (GMO, LMO)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Increases in the numbers of immunocompromised patients and the emergence of drug-resistance pathogens have led to the need for new, safe antimicrobial agents.
The incidence and diversity of invasive fungal/bacterial/virus infections are growing, and fungal pathogens area are a global threat to public health. Unfortunately, many existing antibiotic agents are ineffective because of the appearance of multidrug-resistant strains. Therefore, there is an urgent need for the discovery and development of novel natural antimicrobial agents isolated from diverse sources.
The goal of this Special Issue is to bring together current views, new insights, and cutting-edge research on the discovery, development and biological roles of natural antimicrobial peptides (AMPs). These include AMPs sourced from all species, from prokaryotes to eukaryotes, including those found in plants, yeasts, and animals.
I look forward to your contribution.

Dr. Jung Ro Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antimicrobial protein
  • Redox regulation, Reactive oxygen species (ROS)
  • Action mode, Defense Mechanism
  • Drug discovery and development

Published Papers (2 papers)

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Research

18 pages, 4098 KiB  
Article
Influence of Sulfonamide Contamination Derived from Veterinary Antibiotics on Plant Growth and Development
by Mi Sun Cheong, Kyung Hye Seo, Hadjer Chohra, Young Eun Yoon, Hyeonji Choe, Vimalraj Kantharaj and Yong Bok Lee
Antibiotics 2020, 9(8), 456; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9080456 - 28 Jul 2020
Cited by 23 | Viewed by 5176
Abstract
Veterinary antibiotics such as sulfonamides are widely used to increase feed efficiency and to protect against disease in livestock production. The sulfonamide antimicrobial mechanism involves the blocking of folate biosynthesis by inhibiting bacterial dihydropteroate synthase (DHPS) activity competitively. Interestingly, most treatment antibiotics can [...] Read more.
Veterinary antibiotics such as sulfonamides are widely used to increase feed efficiency and to protect against disease in livestock production. The sulfonamide antimicrobial mechanism involves the blocking of folate biosynthesis by inhibiting bacterial dihydropteroate synthase (DHPS) activity competitively. Interestingly, most treatment antibiotics can be released into the environment via manure and result in significant diffuse pollution in the environment. However, the physiological effects of sulfonamide during plant growth and development remain elusive because the plant response is dependent on folate biosynthesis and the concentration of antibiotics. Here, we present a chemical interaction docking model between Napa cabbage (Brassica campestris) DHPS and sulfamethoxazole and sulfamethazine, which are the most abundant sulfonamides detected in the environment. Furthermore, seedling growth inhibition was observed in lentil bean (Lens culinaris), rice (Oryza sativa), and Napa cabbage plants upon sulfonamide exposure. The results revealed that sulfonamide antibiotics target plant DHPS in a module similar to bacterial DHPS and affect early growth and the development of crop seedlings. Taking these results together, we suggest that sulfonamides act as pollutants in crop fields. Full article
(This article belongs to the Special Issue Novel Peptides against Pathogenic Cells)
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10 pages, 2412 KiB  
Article
Antifungal Effect of A Chimeric Peptide Hn-Mc against Pathogenic Fungal Strains
by Jin-Young Kim, Seong-Cheol Park, Gwangbok Noh, Heabin Kim, Su-Hyang Yoo, Il Ryong Kim, Jung Ro Lee and Mi-Kyeong Jang
Antibiotics 2020, 9(8), 454; https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics9080454 - 28 Jul 2020
Cited by 7 | Viewed by 2345
Abstract
It is difficult to identify new antifungal agents because of their eukaryotic nature. However, antimicrobial peptides can well differentiate among cell types owing to their variable amino acid content. This study aimed to investigate the antifungal effect of Hn-Mc, a chimeric peptide comprised [...] Read more.
It is difficult to identify new antifungal agents because of their eukaryotic nature. However, antimicrobial peptides can well differentiate among cell types owing to their variable amino acid content. This study aimed to investigate the antifungal effect of Hn-Mc, a chimeric peptide comprised of the N-terminus of HPA3NT3 and the C-terminus of melittin. We evaluated its potent antifungal activity at low minimal inhibitory concentrations (MICs) ranging from 1–16 μM against pathogenic yeast and molds. The cell-type specificity of Hn-Mc was mediated through the formation of a random α-helical structure to mimic the fungal membrane environment. Furthermore, Hn-Mc caused cell death in C. tropicalis and F. oxysporum by inducing apoptosis via the generation of reactive oxygen species (ROS) due to mitochondrial damage. The present results indicate that Hn-Mc has a high affinity for the fungal plasma membrane and induces apoptosis in fungal cells, and provide guidance for the development of new antifungal agents. Full article
(This article belongs to the Special Issue Novel Peptides against Pathogenic Cells)
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