Special Issue "Antimicrobial and Antioxidant Activities of Natural Compounds and Synthetic Derivatives: Pharmacological Screening and Mechanism of Action"
Deadline for manuscript submissions: 1 October 2021.
Interests: natural and synthetic compounds; antimicrobial and antimycotic properties; molecular mechanisms of antibiotic resistance; antibiofilm compounds; Malassezia and Candida spp; carbapemenase resistance; MRSA
Interests: bacterial and fungal mechanisms of persistence in the host; molecular epidemiology and characterization of antibiotic resistance determinants in bacteria of clinical interest; antibacterial and antifungal effects of unconventional antimicrobial agents
Interests: isolation and structure elucidation of natural compounds from microorganisms and plants; synthesis and derivatization of natural products; chromatographic techniques; analytical and spectroscopic techniques
Special Issues and Collections in MDPI journals
Antimicrobial agents have represented a very powerful tool in the clinical management of infectious diseases since their first discovery in the early 20th century. However, the growing number of multi-drug resistant microorganisms has drastically reduced antibiotic efficacy, due also to their not always appropriate or excessive use. In the last few decades, only a few new antibiotics have been introduced, leading to depleted antibiotic reserves and, thus, reduced possibility to manage multi-resistant infections. This new scenario has forced worldwide research into the screening of new antimicrobials.
Oxidative stress occurs when there is an imbalance between free radical activity and antioxidant defence activity. When functioning properly, free radicals can help fight off pathogens, but if in excess they can contribute to the pathophysiology of several chronic diseases, such as cancer, diabetes, and neurodegenerative and cardiovascular diseases. In recent years, it has been shown that some infections also cause oxidative stress.
Natural products from plants, fungi and bacteria have been successfully used in the past for their antimicrobial and antioxidant activity. Many bacteria or yeast metabolites have been used as starting chemical skeletons for the generation of semi-synthetic drugs with improved biological activity. However, the search for new compounds with antimicrobial and antioxidant properties remains an area still largely to be explored.
The goal of this Special Issue is the exploration of new compounds of natural origin, but also their analogues of synthesis, to develop new and urgently needed antimicrobial and antioxidant therapies.
Prof. Elisabetta Buommino
Prof. Maria Rosaria Catania
Prof. Marina DellaGreca
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- New natural antimicrobial compounds
- Synthetic natural product derivatives
- Antimicrobial effects (included anti biofilm activity)
- Joint antimicrobial and antioxidant properties
- Molecular mechanisms of novel compounds
- Activity as disinfectants
- Clinical applications
- Multidrug resistant strains
- Discovery of novel therapies to overcome known antimicrobial resistance mechanisms and/or to restore susceptibility to conventional antibiotics (synergistic effect)