Diagnostic Concepts of Urinary Tract Infection and Antimicrobial Treatment

Dear Colleagues,

Urinary tract infections are among the most frequent bacterial infections and comprise benign infections, such as uncomplicated cystitis, as well as life-threatening infections, such as urosepsis. Their causative pathogens are characterized by increasing antimicrobial resistance and multidrug resistance. Novel diagnostic concepts include symptomatic assessments in benign and severe infections, point of care microbiology investigations such as flowcytometry, MALDI-TOF, phenotype or genotype directed testing of the presence of bacteriuria, urinary tract infection, up to rapid susceptibility testing. In the future, molecular-based assessments might be able to better profile and classify urinary tract infections.

Rapid, point of care diagnostic concepts will lead to improved diagnostic accuracy and increased adequate treatment approaches. This will help decrease morbidity, duration of the infection and help to include antimicrobial stewardship aspects in the therapeutic regimens.

Antimicrobial treatment is currently the primary treatment regimen in urinary tract infections, associated with increasing antimicrobial resistance and collateral damage on the microbiome. In the light of this, strategies to decrease the emergence of antimicrobial resistance and negative impact on the microbiome are necessary.

This Special Issue welcomes research on new diagnostic and evaluation concepts in all kinds of urinary tract infections, including point-of-care test systems, their impact on therapy, and therapeutic concepts minimizing the risk of emergence of antibiotic resistance and microbiome damage.

Prof. Dr. Florian Wagenlehner
Guest Editor

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• urine diagnostics
• point-of-care test systems
• rapid microbiology
• symptom assessment
• early warning scores
• molecular assessments
• optimized antibiotic therapy
• protection of the microbiome