CAR-T Cell Metabolism
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 27627
Special Issue Editor
Interests: CAR-T cell metabolism; metabolic reprogramming; metabolism and differentiation; mitochondrial function; mitochondrial fitness
Special Issue Information
Dear Colleagues,
This Special Issue of Antibodies focuses on metabolic approaches to enhance the effectiveness of CAR-T cells in blood-based malignancies and solid tumors. CARs are genetically engineered receptors containing distinct modules, including single chain variable fragments that collectively confer antigen specificity, signal transduction, metabolic reprogramming, and effector function. Previously, we showed how the metabolic properties of T cells can be dynamically regulated by emphasizing signaling and metabolic pathways downstream of the CAR. While CAR-T cells redirected against CD19 provide durable responses in several B cell malignancies, the success of CAR-T cells in solid tumors has been limited. The metabolic nature of solid tumor environment has been implicated as an important factor impeding CAR-T cell effector function. Competition for nutrients in solid tumors provides a barrier to CAR-T cell therapies as antigen-stimulated CARTs can’t overcome the energy cost to proliferate and differentiate into functionally-competed effector cells with cytolytic activity. This Special Issue aims to highlight advanced approaches to confer distinct metabolic attributes to CAR-T cells providing resistance to metabolic checkpoints in the solid tumor environment.
Dr. Roddy O'Connor
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CAR-T cells
- metabolism
- metabolic reprogramming
- blood-based malignancies
- solid tumors