Special Issue "The Production of Engineered Antibodies against Ion Channel Proteins"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 May 2020).
Interests: tumor biology; ion channels; tumor microenviroment; antibody engineering
Since the advent of Hybridoma Technology in the late 1970s, the production of antibodies has had a great impact both in the diagnostic and clinical field. Despite the undeniable therapeutic advantages brought by antibodies, presently used widely in the clinic for a variety of diseases including cancer, the need of more versatile tools has grown exponentially. The response to this need has been the development of recombinant antibodies, as they conjugate the targeting specificity with the advantage of their small size. In this field, several different formats have been developed, spacing from mono- to bi-specificity (e.g., scFv, scDb). In parallel, the need for new targets has profoundly arisen, and ion channels are now established as a class of proteins involved in several physiological and pathological conditions and are widely considered as prospective targets.
So far, novel possibilities have been opened up by the use of recombinant antibodies for novel clinical approaches both in therapy and diagnostics. Moreover, they offer the possibility of conjugation with other moieties and specific ligands, such as TRAIL. Consequently, engineered antibodies do not only function as simple molecules which retain antigen specificity, but they become real devices to be used for personalized medicine, as well as molecular imaging. In this scenario, the targeting of ion channels can offer several advantages, both from a diagnostic and therapeutic point of view.
This Special Issue is aimed at providing an updated overview of the emerging field of engineered antibodies directed against ion channels, including their production, purification, and functionalization, as well as their application for diagnostic, therapy, targeting, and in vitro and in vivo imaging.
Prof. Annarosa Arcangeli
Dr. Claudia Duranti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- engineered antibodies
- ion channels
- ab functionalization
- antibody applications for therapy and diagnostics