Special Issue "Novel Antioxidant Mechanisms and Lifestyle Interventions for the Management of Oxidative Stress in Obesity and Related Adverse Health Effects"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Ileana Marina Terruzzi
E-Mail Website
Guest Editor
Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20122 Milano MI, Italy
Interests: nutrition; nutraceuticals; nutrigenomics; metabolism; metagenomics; obesity; malnutrition prevention and treatment
Special Issues and Collections in MDPI journals
Dr. Pamela Senesi
E-Mail Website
Guest Editor
Department of Biomedical Sciences for Health, University of Milan, 20131 Milan, Italy
Interests: nutrition; translational medicine; insulin signaling; cardiometabolic disorders; physical exercise; biotechnology advances; proteomics and metabolomics; culture and animal studies

Special Issue Information

Dear Colleagues,

Obesity and oxidative stress (OxS) are strictly interconnected and are conceived as a vicious circle. Excessive fat accumulation causes mitochondrial dysfunction, which in turn causes oxidative stress through the overproduction of reactive oxygen species (ROS).

OxS exacerbates obesity by altering fat cells’ plasticity, the mechanism of activation of the hypothalamic satiety center, and worsening chronic inflammation. OxS is a crucial factor that leads to the development of inflammation and subsequent metabolic syndrome. Moreover, ROS overproduction is a major player in the pathophysiology of cardiovascular disease.

Lifestyle plays an important role in promoting or counteracting OxS onset and, consequently, the risk of obesity, diabetes, and cardiovascular disease. While excessive consumption of energy-rich foods and sedentary lifestyle promote OxS, healthy diet and physical exercise are associated with significant reduction in the risk of ROS overproduction. Lifestyle modification and innovative antioxidant strategies represent a promising and effective approach in managing obesity and related comorbidities.

In this Special Issue, we will discuss the latest advances in the knowledge on oxidative stress mechanisms involved in obesity and in obesity-associated comorbidities, and we will analyze preclinical and clinical data focusing on therapies aiming to counteract obesity oxidative stress. 

Prof. Ileana Marina Terruzzi
Dr. Pamela Senesi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Signaling cascade involved in oxidative stress
  • Obesity and obesity-correlated comorbidities
  • Innovative antioxidant therapies
  • Diet interventions
  • Physical exercise

Published Papers

This special issue is now open for submission.
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