Electrochemical Methods for Redox Active Molecules (RAMs) and Reactive Oxygen Species (ROS) Detection

Dear Colleagues,

The omnipresence of redox active molecules (RAMs) and reactive oxygen species (ROS) is well controlled by antioxidants, whereas cell life depends on a suitable equilibrium between antioxidants and pro-oxidants (ROS and RAMs). Low concentrations of ROS stimulate mitosis and cell proliferation, while higher doses inhibit the cell cycle, leading to apoptosis or necrosis. Thus, under normal physiological conditions, ROS and RAMs exert beneficial functions, such as redox signalling pathways and antimicrobial activities, while antioxidant status deregulation is implicated in the development of severe diseases, such as diabetes, cancer, tumors, and several neurodegenerative conditions. Therefore, given the role of such redox species in cellular processes, the monitoring of unavoidable levels of ROS, RAMs, and byproducts from the oxidation of biomolecules may allow us to map out the complex relationships of pro-oxidants and antioxidants in cell biochemistry and pathology. Due to the instability and mutual interference of ROS and most RAMs, reliability of results is not easy to achieve, with the employment of more than one approach, including the determination of antioxidants, being recommended. The use of spectroscopic techniques such as fluorescence, chemiluminescence, electron spin resonance, and biochemical methods is traditional, whereas biosensing and electrochemical methods are emerging as cheaper suitable alternatives.

Prof. Dr. Eric de Souza Gil
Guest Editor

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• Reactive oxygen species (ROS)
• Redox-active molecules (RAMs)
• Pro-oxidants
• Redox signaling
• Oxidative stress
• Antioxidant determination