Dear Colleagues,

Reactive oxygen species (ROS), including free radicals, play a pivotal role in the pathogenesis and development of cardiovascular diseases (CVDs); however, the underlying mechanisms have not been fully elucidated. A redox imbalance between production of free radicals and antioxidant capacity can cause oxidative damage affected by specific targets, such as inflammatory mediators, adhesion molecules, endothelial tissue, low-density lipoproteins (LDLs), leucocytes, and other factors. Their disturbance or alteration via intracellular signaling pathways can promote acute or chronic changes in the cardiovascular system. Due to the multifactorial influence of oxidative stress in CVD genesis and the numerous interlinked cellular cascades, novel integrative approaches may reveal new insights into the basis, progression, and treatment of CVD pathophysiology.

We invite investigators to contribute research papers, as well as review articles, that develop our understanding of ROS-dependent signaling mechanisms and new therapeutic targets against CVDs. Potential topics include, but are not limited to:

• intracellular signaling cascades and redox-sensitive transcription factors, targeting free radicals and antioxidants, that contribute to our understanding of the mechanisms of CVDs;
• identifying new biological pathways (e.g., the endocannabinoid system) that underlie cardiovascular complications mediated by ROS;
• therapeutic interventions against CVDs, such as pharmacological and genetic antioxidant therapy; and
• exercise-induced alterations in oxidative stress and inflammatory processes related to CVDs.

Dr. Anikó Pósa

Dr Renáta Szabó

Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• free radicals
• cardiovascular diseases
• antioxidant therapy
• physical exercise
• signaling cascades related to cardiovascular disease (CVD) pathologies.

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