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Special Issue Editors

Dr. Diego Sánchez

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Guest Editor

Departamento de Bioquímica y Biología Molecular y Fisiología, Instituto de Biología yGenética Molecular, Universidad de Valladolid-CSIC, Valladolid, Spain
Interests: glia; myelination; oxidative stress; apolipoprotein D; lipocalins

Dr. Mario Ruiz

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Co-Guest Editor

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
Interests: membranes; lipids; adiponectin receptors; lipocalins

Dr. Bo Åkerström

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Co-Guest Editor

Department of Clinical Sciences, Section for Infection Medicine, Lund University, Lund, Sweden
Interests: oxidative stress; antioxidation; lipocalins; protein chemistry; alpha-1-microglobulin

Special Issue Information

Dear Colleagues,

Alterations in the homeostasis of lipids due to their oxidation are related to physiological aging; this is a recognized basis for inflammation and many human diseases, such as diabetes, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation by reactive species yields toxic by-products that, in turn, alter the structure and function of many biomolecules. A number of lipid-binding proteins are reported to show antioxidant capabilities, in which different mechanisms are involved. For example, some proteins bind sensitive lipids and shield them to prevent oxidation, whereas other proteins are able to bind oxidized lipids and enzymatically reduce them. Additionally, some protein biological functions are susceptible of the effects of oxidation. It is therefore critical to understand the antioxidant properties of lipid-binding proteins, as well as to evaluate the significance of their oxidative modifications, to properly assay the relevance of extrinsic antioxidants used as therapeutic agents in human diseases.

This Special Issue of Antioxidants seeks to provide an update of this intriguing subject. We aim to assemble original research articles reporting experimental data on the mechanistic roles of lipid-binding proteins when protecting cells against oxidative stress.

We look forward to your contribution and will be very happy to discuss your suggestions.

Dr. Diego Sánchez
Guest Editor

Dr. Bo Åkerström
Dr. Mario Ruiz
Co-Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Lipid-binding proteins
Oxidative stress
Lipid oxidation
Antioxidation
Heme
Lipocalins

Published Papers (2 papers)

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Research

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13 pages, 984 KiB

Open AccessArticle

Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus

by Ricardo Rodríguez-Calvo, Minerva Granado-Casas, Alejandra Pérez-Montes de Oca, María Teresa Julian, Mar Domingo, Pau Codina, Evelyn Santiago-Vacas, Germán Cediel, Josep Julve, Joana Rossell, Lluís Masana, Didac Mauricio, Josep Lupón, Antoni Bayes-Genis and Núria Alonso

Antioxidants 2023, 12(3), 645; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox12030645 - 04 Mar 2023

Cited by 2 | Viewed by 1578

Abstract

Subjects with type 2 diabetes mellitus (T2D) are at increased risk for heart failure (HF). The cardiac-specific (FABP3) and adipose-tissue-specific (FABP4) types of the fatty acid binding proteins have been associated with both all-cause and cardiovascular (CV) mortality. The aim of this study was to explore the prognosis value of FABP3 and FABP4 in ambulatory subjects with chronic HF (CHF), with and without T2D. A prospective study involving 240 ambulatory CHF subjects was performed. Patients were followed-up for a mean of 5.78 ± 3.30 years and cause of death (if any) was recorded. Primary endpoints were defined as all-cause and CV death, and a composite endpoint that included CV death or hospitalization for HF was included as a secondary endpoint. Baseline serum samples were obtained and the serum FABP3 and FABP4 concentrations were assessed by sandwich enzyme-linked immunosorbent assay. Survival analysis was performed with multivariable Cox regressions, using Fine and Gray competing risks models when needed, to explore the prognostic value of FABP3 and FABP4 concentrations, adjusting for potential confounders. Type 2 diabetes mellitus was highly prevalent, accounting for 47.5% for total subjects with CHF. Subjects with T2D showed higher mortality rates (T2D: 69.30%; non-T2D: 50.79%, p = 0.004) and higher serum FABP3 (1829.3 (1104.9–3440.5) pg/mL vs. 1396.05 (820.3–2362.16) pg/mL, p = 0.007) and FABP4 (45.5 (27.6–79.8) ng/mL vs. 34.1 (24.09–55.3) ng/mL, p = 0.006) concentrations compared with non-T2D CHF subjects. In the whole study cohort, FABP3 was independently associated with all-cause death, and both FABP3 and FABP4 concentrations were associated with CV mortality. The predictive values of these two molecules for all-cause (FABP3: HR 1.25, 95% CI 1.09–1.44; p = 0.002. FABP4: HR 2.21, 95% CI 1.12–4.36; p = 0.023) and CV mortality (FABP3: HR 1.28, 95% CI 1.09–1.50; p = 0.002. FABP4: HR 4.19, 95% CI 2.21–7.95; p < 0.001) were only statistically significant in the subgroup of subjects with T2D. Notably, FABP4 (HR 2.07, 95% CI 1.11–3.87; p = 0.022), but not FABP3, also predicted the occurrence of the composite endpoint (death or hospitalization for HF) only in subjects with T2D. All these associations were not found in CHF subjects without T2D. Our findings support the usefulness of serum FABP3 and FABP4 concentrations as independent predictors for the occurrence of all-cause and CV mortality in ambulatory subjects with CHF with T2D. Full article

(This article belongs to the Special Issue Lipid-Binding Proteins and Oxidative Stress in Health and Disease)

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Review

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23 pages, 2054 KiB

Open AccessReview

Exploring the Role of Lipid-Binding Proteins and Oxidative Stress in Neurodegenerative Disorders: A Focus on the Neuroprotective Effects of Nutraceutical Supplementation and Physical Exercise

by Giorgia Scarfò, Rebecca Piccarducci, Simona Daniele, Ferdinando Franzoni and Claudia Martini

Antioxidants 2022, 11(11), 2116; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11112116 - 27 Oct 2022

Cited by 7 | Viewed by 1958

Abstract

The human brain is primarily composed of lipids, and their homeostasis is crucial to carry on normal neuronal functions. In order to provide an adequate amount of lipid transport in and out of the central nervous system, organisms need a set of proteins able to bind them. Therefore, alterations in the structure or function of lipid-binding proteins negatively affect brain homeostasis, as well as increase inflammation and oxidative stress with the consequent risk of neurodegeneration. In this regard, lifestyle changes seem to be protective against neurodegenerative processes. Nutraceutical supplementation with antioxidant molecules has proven to be useful in proving cognitive functions. Additionally, regular physical activity seems to protect neuronal vitality and increases antioxidant defenses. The aim of the present review was to investigate mechanisms that link lipid-binding protein dysfunction and oxidative stress to cognitive decline, also underlining the neuroprotective effects of diet and exercise. Full article

(This article belongs to the Special Issue Lipid-Binding Proteins and Oxidative Stress in Health and Disease)

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