Structure, Function and Biosynthesis of Mammalian Selenoproteins
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 21401
Special Issue Editors
Interests: biopharmaceutics; cellular target-inhibitor interaction; nanomedicine; drug targeting; drug delivery; nanoparticle carrier; biochemical pharmacology; pharmaceutical biotechnology; thioredoxin reductase; thioredoxin; GPX4; anti-tumor drugs
Special Issues, Collections and Topics in MDPI journals
Interests: drugs based on targeting the regulation of thiol redox system; novel biopharmaceutical technology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As is well known, selenoproteins play important roles in mammalian health and diseases, and some selenoproteins have become targets in drug design and development. In humans, twenty-five selenoproteins have been identified, including thioredoxin reductase (TXNRD1, TXNRD2, and TXNRD3), glutathione peroxidase (GPX1, GPX2, GPX3, GPX4, and GPX6), iodothyronine deiodinase (DIO1, DIO2, and DIO3), MSR1, SEPHS2, and other selenoproteins (selenoprotein F, H, I, K, M, N, O, P, S, T, V, W). Many studies have shown that selenoproteins participate in various cellular processes, such as antioxidation, proliferation, and signaling transduction, and consequently play critical roles in human diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases, and so on.
However, the catalytic mechanisms of many selenoenzymes are obscure, while the specific functions of many selenoproteins are still unknown. Additionally, the structures of many selenoproteins have not been defined up to date, which dramatically limits the development and application of drugs targeting selenoproteins. What is more, selenocysteine is encoded by an in-frame opal codon (UGA) and requires many cis and trans factors in cells, making the biosynthesis of selenoprotein difficult. For this reason, it is essential to investigate the mechanism of selenocysteine insertion machinery and develop novel methods for selenocysteine insertion.
To solve scientific issues correlated with human health and diseases, mammalian selenoproteins have been recruited and utilized by researchers for numerous studies. The structural information, drug targeting and biological properties, physiological and pathological functions, and biosynthesis of mammalian selenoproteins are working out in many ongoing in-depth investigations. Thus, in this Special Issue, we aim to collect all the latest review articles and original research articles on topics including but not limited to:
- Crystal structure and structural analysis of selenoproteins;
- Catalytic mechanism of Sec-containing oxidoreductases;
- New substrates of Sec-containing oxidoreductases;
- Biological functions of selenoproteins;
- Regulation of intracellular roles of selenoproteins;
- Mechanisms of eukaryote/prokaryote selenocysteine insertion machinery;
- Biomacromolecules’ interaction in selenocysteine insertion machinery;
- Biosynthesis and efficient purification of selenoproteins;
- Pharmacological effects of selenium-containing compounds.
Dr. Jianqiang Xu
Prof. Dr. Jun Lu
Guest Editors
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Keywords
- mammalian selenoproteins
- characterization of selenoenzymes
- crystal structure of selenoproteins
- structural analysis of selenoproteins
- functions of selenoproteins
- drug–selenoprotein interactions
- cellular signaling pathways
- selenoprotein biosynthesis