NADPH Oxidases and Chronic Inflammation-Associated Cancers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2589

Special Issue Editor

Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Interests: cancer; cytokine-mediated enzymatic up-regulation; hydrogen peroxide; inflammation; NADPH oxidases; oxidative stress; reactive oxygen species; superoxide

Special Issue Information

Dear Colleagues,

You are cordially invited to submit original research articles and reviews for a new Special Issue entitled "NADPH Oxidases and Chronic Inflammation-Associated Cancers".

Chronic inflammation is a pathological condition characterized by a continued active inflammation response and tissue destruction. During chronic inflammation, a wide array of intracellular signaling pathways, comprising cell surface receptors, kinases, and transcription factors, are often dysregulated, leading to abnormal expression of pro-inflammatory genes involved in malignant transformation. Currently, epidemiological data indicate that over 25% of all cancers are related to chronic infection and other types of unresolved inflammation. Mounting evidence supports the hypothesis that chronic inflammation is an important risk factor for the development of cancer, including the observation that prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs) demonstrates protective action against the development of colon adenomas, and breast, prostate, and lung cancers.

Oxidative stress plays a critical role in modulating the immune response to inflammatory stimuli. Recent evidence suggests that one source of ROS that accompanies acute and chronic inflammation in many organs is one or more members of the NADPH oxidase (NOX) family. NOX membrane proteins (NOX1-5, (Dual oxidase) DUOX1-2) catalyze isoform-specific superoxide or hydrogen peroxide generation in non-phagocytic cells, including vascular endothelium and tumor cells. There is a growing body of evidence demonstrating that one major effect of inflammation-induced cytokine secretion is the up-regulation of NOX homologues, contributing to the development of an oxidative microenvironment. This site- and tumor tissue-specific ROS formation influences tissue injury, DNA damage, and activation of a DNA repair response; therefore, efforts to prevent NOX up-regulation or to interfere with NOX function in chronic inflammatory states may be one important approach to preventing oxidative stress-related carcinogenesis.

This Special Issue aims to provide a forum collection of the latest in vitro and in vivo studies on the role of NAPDH oxidase-produced ROS in the initiation and progression of cancers related to chronic inflammation.

We look forward to your contribution.

Dr. Jennifer L. Meitzler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NADPH oxidases
  • inflammation
  • cancer
  • oxidative stress
  • reactive oxygen species

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

14 pages, 1848 KiB  
Review
Zebrafish Models to Study the Crosstalk between Inflammation and NADPH Oxidase-Derived Oxidative Stress in Melanoma
by Irene Pardo-Sánchez, Diana García-Moreno and Victoriano Mulero
Antioxidants 2022, 11(7), 1277; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11071277 - 28 Jun 2022
Cited by 3 | Viewed by 2190
Abstract
Melanoma is the deadliest form of skin cancer, and its incidence continues to increase. In the early stages of melanoma, when the malignant cells have not spread to lymph nodes, they can be removed by simple surgery and there is usually low recurrence. [...] Read more.
Melanoma is the deadliest form of skin cancer, and its incidence continues to increase. In the early stages of melanoma, when the malignant cells have not spread to lymph nodes, they can be removed by simple surgery and there is usually low recurrence. Melanoma has a high mortality rate due to its ability to metastasize; once melanoma has spread, it becomes a major health complication. For these reasons, it is important to study how healthy melanocytes transform into melanoma cells, how they interact with the immune system, which mechanisms they use to escape immunosurveillance, and, finally, how they spread and colonize other tissues, metastasizing. Inflammation and oxidative stress play important roles in the development of several types of cancer, including melanoma, but it is not yet clear under which conditions they are beneficial or detrimental. Models capable of studying the relevance of inflammation and oxidative stress in the early steps of melanocyte transformation are urgently needed, as they are expected to help recognize premetastatic lesions in patients by improving both early detection and the development of new therapies. Full article
(This article belongs to the Special Issue NADPH Oxidases and Chronic Inflammation-Associated Cancers)
Show Figures

Figure 1

Back to TopTop