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Antioxidants
Special Issues
Oxidative Stress in Gastrointestinal Diseases: Challenges and Opportunities
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Oxidative Stress in Gastrointestinal Diseases: Challenges and Opportunities

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4679

Special Issue Editors

Prof. Dr. Marília O. F. Goulart

E-Mail Website
Guest Editor
Electrochemistry and Oxidative Stress Laboratory, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió 57072-970, AL, Brazil
Interests: oxidative-stress-based diseases; antioxidants; bioactive plant products; biomarkers, molecular electrochemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Fabiana Andréa Moura

E-Mail Website
Guest Editor
College of Nutrition, Federal University of Alagoas, Maceió 57072-970, Alagoas, Brazil
Interests: oxidative-stress-based diseases; intestinal bowel diseases; animal models

Special Issue Information

Dear Colleagues,

Inflammatory bowel diseases (IBDs) are chronic inflammatory manifestations in bowel, characterized by episodes of attenuation and sharpening of symptoms. They comprise Crohn’s disease (CD) and idiopathic ulcerative colitis (UC). They have a multifactorial character, with the contribution of environmental factors, intestinal microbiota, individual genetic susceptibility, as well as immunological and psychological factors, with emphasis on the role of inflammation and oxidative stress in their emergence. Drug treatment, which is used for a prolonged time by patients, may be used with the appearance of adverse effects, dependence, and/or refractoriness to the disease. Studies have pointed out that compounds with antioxidant/anti-inflammatory effects can be considered a complementary alternative treatment for IBD.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning diagnostics, nutritional aspects, disease treatment, and advanced therapies, with special emphasis on antioxidants and microbiota modulation.

We welcome the submission of articles and reports with high scientific standard on the medical specialty concerned with the prevention and diagnosis (clinical alternatives to colonoscopy) of IBDs, monoclonal antibodies treatment, biomarkers for diagnosis and clinical follow-up, surgical treatment, and nutritional strategies (including probiotic, prebiotic, and symbiotic therapy) for clinical remission induction and maintenance.

We believe that this Special Issue, "Oxidative Stress and Inflammation in Gastrointestinal Diseases: Challenges and Opportunities" will help to highlight the most recent advances in aspects related to Oxidative Stress and Inflammation in Gastrointestinal Diseases.

We look forward to your contributions.

Dr. Marília O. F. Goulart
Dr. Fabiana Andréa Moura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress in inflammatory bowel disease
  • anti-inflammatory agents
  • nutritional strategies in IBD
  • monoclonal antibodies treatment
  • biomarkers to diagnosis and clinical follow-up
  • microbiota
  • disbiosis in IBD
  • biological therapy in IBD
  • calprotectin
  • curative/preventive effects of dietary antioxidants
  • pathophysiology of gastrointestinal diseases
  • gastrointestinal protection

Published Papers (2 papers)

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Research

18 pages, 3779 KiB  
Article
Quercetin Prevents Intestinal Stem Cell Aging via Scavenging ROS and Inhibiting Insulin Signaling in Drosophila
by La Yan, Xiaoxin Guo, Juanyu Zhou, Yuedan Zhu, Zehong Zhang and Haiyang Chen
Antioxidants 2023, 12(1), 59; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox12010059 - 27 Dec 2022
Cited by 2 | Viewed by 1924
Abstract
Adult stem cells, a class of cells that possess self-renewal and differentiation capabilities, modulate tissue regeneration, repair, and homeostasis maintenance. These cells undergo functional degeneration during aging, resulting in decreased tissue regeneration ability and increased disease incidence. Thus, it is essential to provide [...] Read more.
Adult stem cells, a class of cells that possess self-renewal and differentiation capabilities, modulate tissue regeneration, repair, and homeostasis maintenance. These cells undergo functional degeneration during aging, resulting in decreased tissue regeneration ability and increased disease incidence. Thus, it is essential to provide effective therapeutic solutions to preventing the aging-related functional decline of stem cells. Quercetin (Que) is a popular natural polyphenolic flavonoid found in various plant species. It exhibits many beneficial effects against aging and aging-related diseases; however, its efficacy against adult stem cell aging remains largely unclear. Drosophila possesses a mammalian-like intestinal system with a well-studied intestinal stem cell (ISC) lineage, making it an attractive model for adult stem cell research. Here, we show that Que supplementation could effectively prevent the hyperproliferation of ISCs, maintain intestinal homeostasis, and prolong the lifespan in aged Drosophila. In addition, we found that Que could accelerate recovery of the damaged gut and improve the tolerance of Drosophila to stressful stimuli. Furthermore, results demonstrated that Que prevents the age-associated functional decline of ISCs via scavenging reactive oxygen species (ROS) and inhibiting the insulin signaling pathway. Overall, our findings suggest that Que plays a significant role in delaying adult stem cell aging. Full article
(This article belongs to the Special Issue Oxidative Stress in Gastrointestinal Diseases: Challenges and Opportunities)
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24 pages, 3921 KiB  
Article
Comparative Study of the Results of Operations in Patients with Tumor and Non-Tumor Obstructive Jaundice Who Received and Did Not Receive Antioxidant Therapy for the Correction of Endotoxemia, Glycolysis, and Oxidative Stress
by Victor Stupin, Igor Abramov, Teymur Gahramanov, Alexey Kovalenko, Natalia Manturova, Petr Litvitskiy, Zalim Balkizov and Ekaterina Silina
Antioxidants 2022, 11(6), 1203; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11061203 - 20 Jun 2022
Cited by 4 | Viewed by 1987
Abstract
Purpose: To compare the results of surgical treatment and changes in biomarkers of cholestasis, endotoxicosis, cytolysis, lipid peroxidation, glycolysis disorders, and inflammation in patients with benign and malignant obstructive jaundice (OJ) in patients receiving and not receiving antioxidant pharmacotherapy (AOT). Patients and methods: [...] Read more.
Purpose: To compare the results of surgical treatment and changes in biomarkers of cholestasis, endotoxicosis, cytolysis, lipid peroxidation, glycolysis disorders, and inflammation in patients with benign and malignant obstructive jaundice (OJ) in patients receiving and not receiving antioxidant pharmacotherapy (AOT). Patients and methods: The study included 113 patients (aged 21–90 years; 47 males and 66 females) who received surgical intervention for OJ due to non-malignant (71%) or malignant tumor (29%) etiologies. Patients were divided into two groups: Group I (n = 61) who did not receive AOT and Group II (n = 51) who received AOT (succinate-containing drug Reamberin) as part of detoxification infusion therapy. The surgical approach and scope of interventions in both groups were identical. Dynamic indicators of endotoxicosis, cholestasis, and cytolysis (total, direct, and indirect bilirubin, alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [AP] and gamma-glutamyltransferase [GGT]), kidney function (urea), lipid peroxidation (malonic dialdehyde, MDA), inflammation (leukocytosis), and glycolysis disorders (lactate dehydrogenase (LDH), glucose) were evaluated. Results: Tumor jaundice, unlike non-tumor jaundice, persisted and was characterized by a more severe course, a higher level of hyperbilirubinemia, and lipid peroxidation. The prognostic value of the direct (and total) bilirubin, MDA, glycemia, and leukocytosis levels on the day of hospitalization, which increased significantly in severe jaundice and, especially, in deceased patients, was established. Decompression interventions significantly reduced levels of markers of liver failure, cytolysis, cholestasis, and lipid peroxidation on day 3 after decompression by 1.5–3 times from initial levels; this is better achieved in non-tumor OJ. However, 8 days after decompression, most patients did not normalize the parameters studied in both groups. AOT favorably influenced the dynamics (on day 8 after decompression) of total and direct bilirubin, ALT, AST, MDA, and leukocytosis in non-tumor jaundice, as well as the dynamics of direct bilirubin, AST, MDA, glucose, and LDH in tumor jaundice. Clinically, in the AOT group, a two-fold reduction in the operative and non-operative complications was recorded (from 23% to 11.5%), a reduction in the duration of biliary drainage by 30%, the length of stay in intensive care units was reduced by 5 days, and even hospital mortality decreased, especially in malignancy-induced OJ. Conclusion: A mechanism for the development of liver failure in OJ is oxidative stress with the appearance of enhanced lipid peroxidation and accompanied by hepatocyte necrosis. Inclusion of AOT in perioperative treatment in these patients improves treatment outcomes. Full article
(This article belongs to the Special Issue Oxidative Stress in Gastrointestinal Diseases: Challenges and Opportunities)
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