Dear colleagues,

The mammalian phospholipase A₂ (PLA₂) superfamily contains more than 50 enzymes that play a central role in various aspects of membrane homeostasis and remodeling, lipid metabolism, lipid signaling, and bioenergetics. The structural and functional diversity of PLA₂ enzymes created a broad area of research that revealed specific roles of particular PLA₂ enzymes in inflammatory and autoimmune diseases, cell proliferation, atherosclerosis, muscle degeneration, skeletal muscle contractility, cardiomyopathy, glucose-induced insulin secretion, cytoprotection, apoptosis, ischemia–reperfusion injury, and more. Because PLA₂-mediated enzymatic activities allow for the spatiotemporal release of saturated and (poly)unsaturated fatty acids of diverse properties in various ways and lead to the formation of redox-active signal-transmitting electrophilic lipids, PLA₂ enzymes play a crucial role in lipid-mediated redox signaling. Nevertheless, the studies on the roles of these enzymes in the overall cellular redox status are still largely undeveloped.

This research topic will focus on the particular roles of PLA₂ enzymes in the mechanism and physiological consequences of actions of electrophilic lipids, the regulation of specific PLA₂ enzymes by the redox status of the cell, and other roles of the products of PLA₂ enzymatic activities that alter the redox status of the cell. Progression in the knowledge of PLA2 enzymes will help us understand and predict the still unexplored cytoprotective and regulatory roles of PLA₂ enzymes in the context of cellular physiology and pathology.

Dr. Martin Jabůrek
Guest Editor

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• Phospholipases A2
• Lipid signaling
• Redox homeostasis
• Electrophilic lipids
• Redox signaling