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Antioxidants
Special Issues
Redox Nutrition and Food Toxicity: Implications for Health and Disease
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Redox Nutrition and Food Toxicity: Implications for Health and Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 6090

Special Issue Editor

Dr. Aristidis S. Veskoukis

E-Mail Website
Guest Editor
Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Argonafton 1, 42132 Trikala, Greece
Interests: oxidative stress; free radicals; redox biomarkers; redox nutrition; antioxidant supplementation; polyphenols; exercise; redox toxicology; redox biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrition is a decisive factor for healthy living and a crucial social marker that affects disease onset. It is a stimulus that can alter redox homeostasis, either by improving the antioxidant profile of organisms or by inducing toxicity through generation of reactive species due to food constituents that act as harmful xenobiotics. Use of redox biomarkers is a common practice for monitoring the biological role of food components on the cellular or tissue level. Based on the above, researchers are invited to submit original or review/opinion articles that point out the current knowledge regarding both the beneficial and noxious role of nutrition and food constituents on health, based on redox homeostasis perturbations.

This Special Issue welcomes submissions concerning several research areas that, among others, comprise:

  • The role of nutrition on health and disease via its ability to modify blood and tissue redox homeostasis;
  • The redox-related toxic action of food constituents on animals and human organisms;
  • The role of redox biomarkers in the revelation of the biochemical and molecular mechanisms through which diet components act;
  • The social aspects of the association of nutrition with health and disease (i.e., the social link).

Dr. Aristidis S. Veskoukis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oxidative stress
  • Redox biomarkers
  • Free radicals
  • Plant extracts
  • Antioxidant administration
  • Redox-related diseases
  • Food toxicity
  • Food additives
  • In vitro vs. in vivo
  • The social link

Published Papers (2 papers)

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Research

17 pages, 3193 KiB  
Article
Redox Biomarker Baseline Levels in Cattle Tissues and Their Relationships with Meat Quality
by Zoi Skaperda, Angeliki Argyriadou, Paraskevi Maria Nechalioti, Maria Alvanou, Sotiria Makri, Efterpi Bouroutzika, Ioannis D. Kyriazis, Fotios Tekos, Aristidis S. Veskoukis, Theodoros Kallitsis, Robin Mesnage, Georgios Arsenos and Demetrios Kouretas
Antioxidants 2021, 10(6), 958; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10060958 - 15 Jun 2021
Cited by 7 | Viewed by 2520
Abstract
Cattle breeds or crossbreds with high productivity traits have been developed to meet a growing demand for food. When intensive farming practices are followed, animals face several challenges which can result in poor performance, compromised welfare and the reduced quality of their products. [...] Read more.
Cattle breeds or crossbreds with high productivity traits have been developed to meet a growing demand for food. When intensive farming practices are followed, animals face several challenges which can result in poor performance, compromised welfare and the reduced quality of their products. Our study aims to highlight the resting values of the physiological oxidative stress that three cattle breeds exhibit, and their potential relationship with meat quality. For this purpose, we determined the levels of five common redox biomarkers (glutathione (GSH), catalase (CAT), total antioxidant capacity (TAC), thiobarbituric reactive substances (TBARS) and protein carbonyls (CARBS)) in the tissues of three commonly used beef cattle breeds (Charolais (CHA), Limousin (LIM) and Simmental (SIM)) and their association with specific meat quality traits that depend on color, pH and texture. The results revealed that LIM cattle breed animals have elevated intrinsic antioxidant defense systems in comparison to CHA and SIM cattle breed animals. In addition, the meat quality parameters were associated with the redox biomarkers. We propose that the determination of specific antioxidant parameters in the blood might be used as potential biomarkers to predict meat quality. This would allow farmers to nutritionally intervene to improve the quality of their products. Full article
(This article belongs to the Special Issue Redox Nutrition and Food Toxicity: Implications for Health and Disease)
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15 pages, 1643 KiB  
Article
Ameliorative Effects of the Sesquiterpenoid Valerenic Acid on Oxidative Stress Induced in HepG2 Cells after Exposure to the Fungicide Benomyl
by Mehtap Kara, Ezgi Öztaş, Tuğçe Boran, Ecem Fatma Karaman, Aristidis S. Veskoukis and Aristides M. Tsatsakis
Antioxidants 2021, 10(5), 746; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10050746 - 08 May 2021
Cited by 8 | Viewed by 2522
Abstract
Valerenic acid (VA) is a sesquiterpenoid and a phytoconstituent of the plant valerian used for sleeping disorders and anxiety. The frequency of using herbal components as therapeutic nutritional agents has increased lately. Their ability to improve redox homeostasis makes them a valuable approach [...] Read more.
Valerenic acid (VA) is a sesquiterpenoid and a phytoconstituent of the plant valerian used for sleeping disorders and anxiety. The frequency of using herbal components as therapeutic nutritional agents has increased lately. Their ability to improve redox homeostasis makes them a valuable approach against harmful xenobiotics. The purpose of this study was to evaluate the putative beneficial role of VA against the redox-perturbating role of the fungicide benomyl in HepG2 human liver cells in terms of oxidative stress in the cellular environment and in endoplasmic reticulum (ER). Benomyl increased cell total oxidant status and reactive oxygen species production and decreased total antioxidant status. The expression of genes coding for antioxidant molecules, namely, heme oxygenase-1, alpha glutathione s-transferase, NF-ĸB, and liver fatty acid binding protein, were decreased due to benomyl. VA ameliorated these effects. Benomyl also increased ER-stress-related molecules such as endoplasmic reticulum to nucleus signaling 1 protein, glucose-regulated protein 78, and caspase-12 levels, and VA acted also as a preventive agent. These results indicate that VA exerts ameliorative effects after benomyl-induced oxidative stress. VA, a widely used nutritional supplement, is a compound with potent antioxidant properties, which are valuable for the protection of cells against xenobiotic-induced oxidative damage. Full article
(This article belongs to the Special Issue Redox Nutrition and Food Toxicity: Implications for Health and Disease)
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