Dear Colleagues,

Cerebrovascular diseases are the second leading cause of death and the main cause of adult long-term disability in developed countries, posing as significant unmet clinical needs, as there are limited therapeutic options for many of these disorders.

Accumulating evidence demonstrates that an interplay between oxidative stress and inflammation contributes significantly to the onset, progression and severity of various cerebrovascular diseases, raising the possibility that the underlying mechanisms are interconnected. Furthermore, studies in patient cohorts suggest that genetic susceptibility factors related to differences in vascular sensitivity to oxidative stress and inflammation contribute to inter-individual differences in disease susceptibility and severity.

This special issue will highlight current knowledge and future prospects on the characterization of the role of oxidative stress and inflammation in blood-brain barrier endothelial dysfunction and cerebrovascular diseases, and the identification of underlying redox-sensitive mechanisms, as well as the development of novel therapeutic strategies, including drug combination and personalized medicine approaches.

In particular, we invite investigators to submit original research articles as well as review articles related to the following topics:

• Role of oxidative stress and/or inflammation in onset and progression of cerebrovascular diseases
• Role of oxidative stress and/or inflammation in neurovascular unit dysfunction and blood–brain barrier hyperpermeability
• Mechanisms underlying the crosstalk between oxidative stress and inflammation in endothelial cells and vascular tissues
• NADPH oxidases as friends or foes of endothelial cells and the vascular system
• Role of NADPH oxidases and reactive oxygen species in cerebrovascular physiology and pathology
• Functional crosstalk between Nrf2 and NF-κB signaling pathways in the regulation of endothelial cell responses to oxidative stress and inflammation
• Role of autophagy in endothelial cell responses to oxidative stress and inflammation
• Role of autophagy in cerebrovascular physiology and pathology
• Genetic susceptibility factors related to differences in vascular sensitivity to oxidative stress and inflammation
• Biomarkers of oxidative stress and inflammation associated with progression and severity of vascular diseases
• Innovative antioxidant and drug combination therapies for prevention and treatment of vascular diseases

Prof. Dr. Saverio Francesco Retta
Dr. Lorenza Trabalzini
Prof. Dr. Masuko Ushio-Fukai
Prof. Dr. Chris Sobey
Guest Editors

Manuscript Submission Information

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