Submit to Antioxidants Review for Antioxidants Propose a Special Issue

Journal Browser

Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 32959

Share This Special Issue

Special Issue Editors

Prof. Dr. Wlodzimierz Opoka

E-Mail Website
Guest Editor

Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland
Interests: edible mushrooms; medicinal mushrooms; culinary–medicinal plants; antioxidant activity
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Bożena Muszyńska

E-Mail Website
Guest Editor

Department of Pharmaceutical Botany, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland
Interests: medicinal mushrooms; secondary metabolites of mushrooms; biological activity of mushrooms: anti-inflammatory, neuroprotective, immunostimulatory; prebiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that oxidative stress plays an important role in the etiopathogenesis of many diseases, including cancer, cardiovascular disorders, and diseases of the central nervous system. Oxidative stress plays an important role in the etiology and course of numerous diseases such as diabetes, arteriosclerosis, Alzheimer’s disease, Parkinson’s disease, chronic kidney disease, and chronic obstructive pulmonary disease. One way to prevent homeostasis disorders that occur as a result of excessive production of pro-oxidative substances is to include ingredients with antioxidant properties in the diet. In physiological conditions, a number of endogenous compounds displaying antioxidant activity contribute to neutralizing the effects of reactive oxygen and nitrogen. Due to their containing biologically active substances, many species of culinary–medicinal mushrooms and plants have antioxidant properties. These substances include certain enzymes (e.g., superoxide dismutase, catalase, and glutathione peroxidase), vitamins, sterols, flavonoids, phenolic compounds, and glutathione, which is considered the strongest antioxidant; ergothioneine, theanine, indole compounds, carotenoids, and some vitamins, macro- and microelements also exhibit antioxidant activity.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research about culinary–medicinal mushrooms or plants as a source of antioxidant substances useful in prophylactics and cures of diseases.

We look forward to your contribution.

Prof. Dr. Wlodzimierz Opoka
Prof. Dr. Bożena Muszyńska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

antioxidant activity
antioxidant substances
antioxidant macro- and microelements
edible mushrooms
medicinal mushrooms
culinary–medicinal plants
gastric juices
oxidative stress

Published Papers (10 papers)

Download All Papers

Research

Jump to: Review

17 pages, 659 KiB

Open AccessArticle

A Randomized Controlled Trial on Pleurotus eryngii Mushrooms with Antioxidant Compounds and Vitamin D₂ in Managing Metabolic Disorders

by Stamatia-Angeliki Kleftaki, Charalampia Amerikanou, Aristea Gioxari, Dimitra Z. Lantzouraki, George Sotiroudis, Konstantinos Tsiantas, Thalia Tsiaka, Dimitra Tagkouli, Chara Tzavara, Lefteris Lachouvaris, Georgios I. Zervakis, Nick Kalogeropoulos, Panagiotis Zoumpoulakis and Andriana C. Kaliora

Antioxidants 2022, 11(11), 2113; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11112113 - 26 Oct 2022

Cited by 2 | Viewed by 2150

Abstract

This study examined the effects of a Pleurotus eryngii mushroom snack on metabolically unhealthy patients. After harvest, mushrooms were baked and subjected to UV-B irradiation to enhance vitamin D₂ content. A randomized controlled trial was conducted for three months with two arms. Both groups received conventional nutritional counseling for metabolic disorders, while the intervention group had to consume the snack daily as well. We collected blood samples at the beginning and the end of the study to determine biochemical measurements and serum 25(OH)D2 and to evaluate inflammation and oxidative stress. One hundred patients consented and were randomized. Comparatively to the control group, snack consumption regulated glucose levels and reduced body weight, fat, waist and hip circumferences. In addition, 25(OH)D2 increased significantly in the intervention group. The levels of LDL and SGOT were lower only in the intervention group. Levels of IL-6 and ox-LDL decreased in the mushroom group, while the overall physical health increased. These findings suggest potential antidiabetic, antiobesity, anti-inflammatory and antioxidant health benefits of the snack to metabolically unhealthy individuals. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Graphical abstract

16 pages, 1438 KiB

Open AccessArticle

Cordyceps militaris—Fruiting Bodies, Mycelium, and Supplements: Valuable Component of Daily Diet

by Karol Jędrejko, Katarzyna Kała, Katarzyna Sułkowska-Ziaja, Agata Krakowska, Piotr Zięba, Krystian Marzec, Agnieszka Szewczyk, Agnieszka Sękara, Jolanta Pytko-Polończyk and Bożena Muszyńska

Antioxidants 2022, 11(10), 1861; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11101861 - 21 Sep 2022

Cited by 6 | Viewed by 6219

Abstract

Cordyceps militaris has long been used in Eastern medicine for alleviating fatigue and as an immunostimulant. The present study aimed to determine the content of biologically active substances (bioelements and organic compounds), the total phenolic content, and the antioxidant activity of fruiting bodies (commercially available and self-cultivated), mycelia, and two food supplements. The results show that substrate composition and cultivation method had an influence on the properties of mushroom materials. An important aspect of the study is the estimation of the content of bioactive substances present after extraction into digestive juices in the artificial gastrointestinal tract model, which can allow for determining the amount of these substances that is potentially bioavailable for the human body. The best results for cordycepin (81.4 mg/100 g d.w.) and lovastatin (53.6 mg/100 g d.w.) were achieved for commercially available food supplements. Furthermore, after digestion in artificial intestinal juice, the highest amount of cordycepin was determined in the fruiting bodies from commercially obtained (25.9 mg/100 g d.w.) and self-cultivated mushroom (25.8 mg/100 g d.w.). In conclusion, the mycelium and fruiting bodies of C. militaris are ideal food supplements and pharmaceutical agents and can serve as a good source of prohealth substances potentially bioavailable for humans. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

16 pages, 348 KiB

Open AccessArticle

Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus

by Jan Stastny, Petr Marsik, Jan Tauchen, Matej Bozik, Anna Mascellani, Jaroslav Havlik, Premysl Landa, Ivan Jablonsky, Jakub Treml, Petra Herczogova, Roman Bleha, Andriy Synytsya and Pavel Kloucek

Antioxidants 2022, 11(8), 1569; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11081569 - 13 Aug 2022

Cited by 11 | Viewed by 3368

Abstract

Within the group of higher fungi, edible medicinal mushrooms have a long history of being used as food and in folk medicine. These species contain biologically active substances with many potential beneficial effects on human health. The Pleurotus genus is representative of medicinal mushrooms because Pleurotus ostreatus is one of the most commonly cultivated culinary mushrooms. In our study, we focused on lesser-known species in the genus Pleurotus and measured their antioxidant and anti-inflammatory activity. We prepared extracts of the mushrooms and analyzed them using HPLC−HRMS, GC−MS, and ¹H-NMR. Significant differences in biological activities were found among the Pleurotus spp. extracts. A MeOH extract of P. flabellatus was the most active as a radical scavenger with the highest ORAC, while a chloroform extract had significant anti-inflammatory COX-2 activity. The 80% MeOH extract of P. flabellatus contained the highest amounts of ergosterol, ergothioneine, and mannitol. The 80% MeOH extract of P. ostreatus Florida was the most active in the NF-κB inhibition assay and had the highest content of β-glucans (43.3% by dry weight). Given the antioxidant and anti-inflammatory properties of P. flabellatus, the potential therapeutic usefulness of this species is worth evaluating through in-depth investigations and confirmation by clinical trials. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

22 pages, 2122 KiB

Open AccessArticle

Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies

by Enas E. Eltamany, Marwa S. Goda, Mohamed S. Nafie, Abdelghafar M. Abu-Elsaoud, Rawan H. Hareeri, Mohammed M. Aldurdunji, Sameh S. Elhady, Jihan M. Badr and Nermeen A. Eltahawy

Antioxidants 2022, 11(7), 1249; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11071249 - 25 Jun 2022

Cited by 13 | Viewed by 2710

Abstract

This study presents a comparison between two mistletoe plants—P. acacia and P. curviflorus—regarding their total phenolic contents and antioxidant and anticancer activities. P. curviflorus exhibited a higher total phenolics content (340.62 ± 19.46 mg GAE/g extract), and demonstrated higher DPPH free radical scavenging activity (IC₅₀ = 48.28 ± 3.41µg/mL), stronger reducing power (1.43 ± 0.54 mMol Fe⁺²/g) for ferric ions, and a greater total antioxidant capacity (41.89 ± 3.15 mg GAE/g) compared to P. acacia. The cytotoxic effects of P. acacia and P. curviflorus methanol extracts were examined on lung (A549), prostate (PC-3), ovarian (A2780) and breast (MDA-MB-231) cancer cells. The highest anticancer potential for the two extracts was observed on PC-3 prostate cancer cells, where P. curviflorus exhibited more pronounced antiproliferative activity (IC₅₀ = 25.83 μg/mL) than P. acacia (IC₅₀ = 34.12 μg/mL). In addition, both of the tested extracts arrested the cell cycle at the Pre-G1 and G1 phases, and induced apoptosis. However, P. curviflorus extract possessed the highest apoptotic effect, mediated by the upregulation of p53, Bax, and caspase-3, 8 and 9, and the downregulation of Bcl-2 expression. In the pursuit to link the chemical diversity of P. curviflorus with the exhibited bioactivities, its metabolomic profiling was achieved by the LC-ESI-TOF-MS/MS technique. This permitted the tentative identification of several phenolics—chiefly flavonoid derivatives, beside some triterpenes and sterols—in the P. curviflorus extract. Furthermore, all of the metabolites in P. curviflorus and P. acacia were inspected for their binding modes towards both CDK-2 and EGFR proteins using molecular docking studies in an attempt to understand the superiority of P. curviflorus over P. acacia regarding their antiproliferative effect on PC-3 cancer cells. Docking studies supported our experimental results; with all of this taken together, P. curviflorus could be regarded as a potential prospect for the development of chemotherapeutics for prostate cancer. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

13 pages, 2006 KiB

Open AccessArticle

Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats

by Fabia Judice Marques Viroel, Leticia Favara Laurino, Érika Leão Ajala Caetano, Angela Faustino Jozala, Sara Rosicler Vieira Spim, Thaisa Borim Pickler, Michelle Klein Sercundes, Marcela C. Gomes, Alessandre Hataka, Denise Grotto and Marli Gerenutti

Antioxidants 2022, 11(6), 1035; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11061035 - 24 May 2022

Cited by 7 | Viewed by 2697

Abstract

The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. Ganoderma lucidum contains a variety of bioactive compounds, such as polysaccharides, proteins and polyphenols that are able to control blood glucose and be used in anti-cancer therapy. We aimed to evaluate the effects of the consumption of Ganoderma lucidum (Gl) on maternal-fetal outcomes in streptozotocin-induced GDM (GDM-STZ). Pregnant rats were exposed to Gl (100 mg/kg/day) before and after the induction of GDM-STZ (single dose 40 mg/kg) on the eighth pregnancy day. Biochemical and oxidative stress parameters, reproductive performance and morphometry of fetuses were assessed. Gl reduced the glycemic response in the oral glucose tolerance test. Moreover, Gl decreased AST and ALT activities. GDM increased lipid peroxidation, which was reverted by Gl. Catalase and glutathione peroxidase activities were decreased in GDM and the administered Gl after the fetus implantation increased catalase activity. Measurements of the fetal head, thorax, craniocaudal and tail showed greater values in fetuses from rats exposed to Gl compared to GDM. Ganoderma lucidum has an encouraging nutritional and medicinal potential against GDM, since it modifies glucose metabolism, reduces lipid peroxidation, and has protective effects in fetuses born from GDM dams. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

26 pages, 3187 KiB

Open AccessArticle

Metabolic Profiling, Chemical Composition, Antioxidant Capacity, and In Vivo Hepato- and Nephroprotective Effects of Sonchus cornutus in Mice Exposed to Cisplatin

by Sameh S. Elhady, Reda F. A. Abdelhameed, Eman T. Mehanna, Alaa Samir Wahba, Mahmoud A. Elfaky, Abdulrahman E. Koshak, Ahmad O. Noor, Hanin A. Bogari, Rania T. Malatani and Marwa S. Goda

Antioxidants 2022, 11(5), 819; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11050819 - 22 Apr 2022

Cited by 11 | Viewed by 2415

Abstract

Sonchus cornutus (Asteraceae) is a wild. edible plant that represents a plentiful source of polyphenolic compounds. For the first time, the metabolic analysis profiling demonstrated the presence of anthocyanidin glycosides, coumarins, flavonoids and their corresponding glycosides, and phenolic acids. The total phenolic compounds were determined to be 206.28 ± 14.64 mg gallic acid equivalent/gm, while flavonoids were determined to be 45.56 ± 1.78 mg quercetin equivalent/gm. The crude extract of S. cornutus exhibited a significant 1,1-diphenyl-2-picrylhydrazyl free radical scavenging effect with half-maximal inhibitory concentration (IC₅₀) of 16.10 ± 2.14 µg/mL compared to ascorbic acid as a standard (10.64 ± 0.82 µg/mL). In vitro total antioxidant capacity and ferric reducing power capacity assays revealed a promising reducing potential of S. cornutus extract. Therefore, the possible protective effects of S. cornutus against hepatic and renal toxicity induced by cisplatin in experimental mice were investigated. S. cornutus significantly ameliorated the cisplatin-induced disturbances in liver and kidney functions and oxidative stress, decreased MDA, ROS, and NO levels, and restored CAT and SOD activities. Besides, it reversed cisplatin-driven upregulation in inflammatory markers, including iNOS, IL-6, and IL-1β levels and NF-κB and TNF-α expression, and elevated anti-inflammatory IL-10 levels and Nrf2 expression. Additionally, the extract mitigated cisplatin alteration in apoptotic (Bax and caspase-3) and anti-apoptotic (Bcl-2) proteins. Interestingly, hepatic, and renal histopathology revealed the protective impacts of S. cornutus against cisplatin-induced pathological changes. Our findings guarantee a protective effect of S. cornutus against cisplatin-induced hepatic and renal damage via modulating oxidative stress, inflammation, and apoptotic pathways. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

21 pages, 1870 KiB

Open AccessArticle

HR-LC-ESI-Orbitrap-MS-Based Metabolic Profiling Coupled with Chemometrics for the Discrimination of Different Echinops spinosus Organs and Evaluation of Their Antioxidant Activity

by Amel Bouzabata, Paola Montoro, Katarzyna Angelika Gil, Sonia Piacente, Fadia S. Youssef, Nawal M. Al Musayeib, Geoffrey A. Cordell, Mohamed L. Ashour and Carlo Ignazio Giovanni Tuberoso

Antioxidants 2022, 11(3), 453; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11030453 - 24 Feb 2022

Cited by 13 | Viewed by 2405

Abstract

This study aimed to assess and correlate the phenolic content and the antioxidant activity of the methanol extracts of the stems, roots, flowers, and leaves of Echinops spinosus L. from north-eastern Algeria. Qualitative analysis was performed by high-resolution mass spectrometry (HR) LC-ESI-Orbitrap-MS and (HR) LC-ESI-Orbitrap-MS/MS). Forty-five compounds were identified in the methanol extracts; some are described for the first time in E. spinosus. Targeted phenolic compounds were quantified by HPLC-DAD and it was shown that caffeoyl quinic derivatives were the most abundant compounds. Chemometric analysis was performed using principal component analysis (PCA) and hierarchical cluster analysis (HCA) based on the qualitative and quantitative LC data. The score plot discriminates different Echinopsis spinosus organs into three distinct clusters, with the stems and flowers allocated in the same cluster, reflecting their resemblance in their secondary metabolites. The antioxidant activities of the methanol extracts were assessed using cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant assay (FRAP), diphenyl picryl hydrazyl radical-scavenging capacity assay (DPPH^●), and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS^●⁺). The root extract exhibited the highest antioxidant activity, evidenced by 3.26 and 1.61 mmol Fe²⁺/g dried residue for CUPRAC and FRAP, respectively, and great free radical-scavenging activities estimated by 0.53 and 0.82 mmol TEAC/g dried residue for DPPH^● and ABTS^●⁺, respectively. The methanol extract of the roots demonstrated a significant level of total phenolics (TP: 125.16 mg GAE/g dried residue) and flavonoids (TFI: 25.40 QE/g dried residue TFII: 140 CE/g dried residue). Molecular docking revealed that tricaffeoyl-altraric acid and dicaffeoyl-altraric acid exhibited the best fit within the active sites of NADPH oxidase (NO) and myeloperoxidase (MP). From ADME/TOPAKT analyses, it can be concluded that tricaffeoyl-altraric acid and dicaffeoyl-altraric acid also revealed reasonable pharmacokinetic and pharmacodynamic characteristics with a significant safety profile. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

13 pages, 863 KiB

Open AccessArticle

Yerba Mate as a Source of Elements and Bioactive Compounds with Antioxidant Activity

by Elżbieta Rząsa-Duran, Agata Kryczyk-Poprawa, Dawid Drabicki, Adrian Podkowa, Katarzyna Sułkowska-Ziaja, Agnieszka Szewczyk, Katarzyna Kała, Włodzimierz Opoka, Piotr Zięba, Maciej Fidurski and Bożena Muszyńska

Antioxidants 2022, 11(2), 371; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11020371 - 12 Feb 2022

Cited by 15 | Viewed by 3900

Abstract

Ilex paraguariensis (yerba mate) is a plant species of the holly genus Ilex native to South America from the family Aquifoliaceae and is used for the production of yerba mate infusion. The leaves of the plant are steeped in hot water to make a beverage known as mate. The present study aimed to quantify and compare the content of selected elements in dried leaves and stems of I. paraguariensis (originating from Paraguay, Argentina, and Brazil) available in the market in Poland and determine the amount of these elements and bioactive compounds that pass into the infusion prepared from them. The contents of the following antioxidant compounds were assessed: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, 4-feruloylquinic acid, isochlorogenic acid, rutoside, astragalin, caffeine, and indole derivatives. All the tested samples showed the presence of elements such as magnesium, zinc, copper, iron, and manganese. The highest antioxidant activity was determined for infusion prepared from yerba mate samples from Brazil. Drinking approximately 1 L of the infusion a day will partially cover the daily requirement of these elements and bioactive compounds. The highest content of organic compounds with antioxidant properties (phenolic compounds and caffeine) was found in yerba mate infusions from Brazil. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

Review

Jump to: Research

16 pages, 1847 KiB

Open AccessReview

The Current Status, Bioactivity, Food, and Pharmaceutical Approaches of Calocybe indica: A Review

by Meghna Shashikant, Aarti Bains, Prince Chawla, Melinda Fogarasi and Szabolcs Fogarasi

Antioxidants 2022, 11(6), 1145; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11061145 - 10 Jun 2022

Cited by 7 | Viewed by 2483

Abstract

Over the past few years, mushrooms have been extensively explored in the field of pharmaceutical and food science, and researchers are heading toward the search for vital components with a higher safety margin and multitarget applications. Moreover, among all age group populations, mushroom consumption has increased immensely owing to their great nutritional aspects, desirable organoleptic properties, and aroma. In addition, mushrooms continue to generate much attention chiefly in their consumption as food, as a cure for different ailments, as well as a vital commodity globally, owing to their dietary, antioxidant, and therapeutic values. Mushrooms are considered one of the important and suitable diets for patients having multiple types of diseases. Additionally, due to potential immunomodulatory effects, quality protein, and low fat, and cholesterol content, mushrooms are used as an important ingredient for food formulation. Therefore, this review article provides detailed information on Calocybe indica as they are the third most important commercially grown mushroom following button and oyster mushrooms. This review brings tangible evidence that milky white mushrooms are a great source of natural components and antioxidants with potential application in pharmaceuticals and in treating and managing different diseases. Several food applications of milky white mushrooms have also been discussed and reviewed. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures

Figure 1

15 pages, 335 KiB

Open AccessReview

Antioxidant-Rich Natural Raw Materials in the Prevention and Treatment of Selected Oral Cavity and Periodontal Diseases

by Jolanta Pytko-Polończyk, Magdalena Stawarz-Janeczek, Agata Kryczyk-Poprawa and Bożena Muszyńska

Antioxidants 2021, 10(11), 1848; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10111848 - 21 Nov 2021

Cited by 6 | Viewed by 3095

Abstract

Antioxidant-rich natural raw materials have been used for thousands of years in traditional medicine. In the past decade, there has been increasing interest in naturotherapy, which is a practice of using products with a natural origin. Natural products can be effective in the treatment and prevention of oral and dental diseases, among others. Such raw materials used in dentistry are characterized by antioxidant, anti-inflammatory, antibacterial, antiviral, antiedematous, astringent, anticoagulant, dehydrating, vitaminizing, and—above all—regenerative properties. Reports have shown that a relationship exists between oral diseases and the qualitative and quantitative composition of the microbiota colonizing the oral cavity. This review aimed to analyze the studies focusing on the microbiome colonizing the oral cavity in the context of using natural raw materials especially herbs, plant extracts, and isolated biologically active compounds as agents in the prevention and treatment of oral and periodontal diseases such as dental caries as well as mucosal changes associated with salivary secretion disorder. The present work discusses selected plant ingredients exhibiting an antioxidant activity with potential for the treatment of selected oral cavity and periodontal diseases. Full article

(This article belongs to the Special Issue Culinary-Medicinal Mushrooms and Plants: Organic Compounds and Bioactive Substances with Antioxidant Activity)

► Show Figures