Oxidative Metabolism, Mitochondrial Damage and Neurodegenerative Disease: A Complex Triumvirat
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 8852
Special Issue Editors
Interests: mathematical modeling; mitochondria; reactive oxygen species; aging; neurodegenerative processes; oxidative metabolism
Interests: depression; metabolism; aging; antidepressant; monoamines; astrocytes
Special Issue Information
Dear Colleagues,
Reactive oxygen species (ROS) are derived forms of atmospheric oxygen with additional electron(s). ROS most likely appeared on Earth together with the first atmospheric oxygen molecules about 2.4–3.8 billion years ago. As signaling molecules, ROS are versatile owing to their diverse properties, and can push the cells or organisms to enter oxidative stress if they are not balanced by antioxidant machinery. Thus, there is a balance between ROS production and antioxidant defenses which is highly regulated. Mitochondria are a key player of this equilibrium, and the major provider of ROS in the cell. In the last decade, evidence has emerged of a direct link between mitochondrial status and the neurodegenerative processes detected in pathologies such as, but not limited to, Parkinson syndrome, Alzheimer’s disease, and optic atrophies.
In this issue, we will explore the different sides of this triumvirate linking oxidative stress, mitochondria, and neurodegenerative diseases. We will collect articles from mathematical to integrative in vitro/in vivo models ranging from molecular to behavioral levels toward analyzing the latest research in the field.
Prof. Noelie Davezac
Prof. Bruno Pierre Guiard
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- reactive oxygen species
- mitochondria
- neurodegenerative processes
- mathematical modelling
- oxidative stress
- systems biology
- brain
- plasticity