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Special Issue Editors

Prof. Dr. Zdeňka Ďuračková

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Guest Editor

Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia
Interests: oxidative stress; Lipoproteins; fatty acids; antioxidant; polyphenols

Dr. Ingrid Žitňanová

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Guest Editor

Associate Professor, Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia
Interests: oxidative stress at the cellular level; natural and synthetic antioxidants; neurodegenerative diseases

Dr. Jana Trebatická

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Guest Editor

Associate Professor, MD, Department of Paediatric Psychiatry, Faculty of Medicine, Comenius University and The National Institute of Children’s Diseases, 833 40 Bratislava, Slovakia
Interests: child psychiatry; psychiatry; ADHD; affective disorders; autism spectrum disorder; eating disorders

Special Issue Information

Dear Colleagues,

Oxidative stress (OS) (redox imbalance), is a phenomenon associated with an imbalance between the formation of reactive oxygen and nitrogen species (ROS/RNS) and protective systems/antioxidants in favor of ROS/RNS formation. Mild OS can play a regulatory role in multiple signaling pathways, while large OS causes damage to important biomolecules, organs, and the whole organism. Intermediate OS can induce cell proliferation.

Increased production of ROS/RNS in the body may result from various external factors or internal pathological conditions (mitochondrial dysfunction, chronic inflammation, dysbalance of neurotransmitters in different signaling pathways) that may initiate pathological processes in the organism.

Oxidative stress is thought to play a role in the pathology of neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's disease, multiple sclerosis, and others. The participation of OS in neuropsychiatric disorders (e.g., schizophrenia, depressive disorder, ADHD, bipolar disorder, and autism) are less well studied. It is not clear whether oxidative stress plays a causal role in their pathology or is a consequence of it. We invite you to submit the latest original research and significant results of your scientific work or review articles with a wide community of colleagues with the same or similar interests in the upcoming Special Issue Pathology Analysis on Redox Imbalance in Neurodegenerative Diseases and Neuropsychiatric Disorders. We welcome in vitro and in vivo studies, as well as pre-clinical and clinical studies involving cellular and molecular mechanisms, pathophysiology of the redox imbalance, new markers of oxidative damage, and their use for pharmacotherapeutic studies.

Prof. Dr. Zdeňka Ďuračková
Dr. Ingrid Žitňanová
Dr. Jana Trebatická
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oxidative stress
ROS/RNS
antioxidants
neurodegenerative diseases
neuropsychiatric disorders
markers of OS
cell culture for OS monitoring

Published Papers (1 paper)

Research

14 pages, 3174 KiB

Open AccessArticle

Stress Hormones Cortisol and Aldosterone, and Selected Markers of Oxidative Stress in Response to Long-Term Supplementation with Omega-3 Fatty Acids in Adolescent Children with Depression

by Henrieta Oravcova, Barbora Katrencikova, Iveta Garaiova, Zdenka Durackova, Jana Trebaticka and Daniela Jezova

Antioxidants 2022, 11(8), 1546; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11081546 - 10 Aug 2022

Cited by 3 | Viewed by 3113

Abstract

Late childhood and adolescence are crucial periods of brain development with high vulnerability to environmental insults. The aim of this study was to test the hypotheses that in adolescents with depression (a) 12 weeks-supplementation with omega-3 fatty acids results in the attenuation of salivary stress hormone concentrations; (b) the mentioned supplementation improves potentially disrupted daily rhythm of stress hormones; (c) stress hormone concentrations correlate with values of selected markers of oxidative stress. The sample consisted of 60 patients suffering from depression aged 11–18 years. Hormone concentrations in saliva were measured in the morning and midday before (baseline) and after (6, 12 weeks) food supplementation with omega-3 or omega-6 (as comparator) fatty acids. Morning cortisol decreased in response to omega-3 but not omega-6 fatty acids at 12 weeks compared to baseline. No changes were observed in aldosterone concentrations. The obtained results show that adolescent children with depression preserved the daily rhythm of both stress hormones. Baseline morning cortisol concentrations correlated positively with depression severity and lipoperoxides, and negatively with docosahexaenoic acid. Aldosterone concentrations correlated positively with 8-isoprostane. Thus, both hormones showed positive correlation with the selected markers of oxidative stress suggesting that enhanced stress hormone secretion may be associated with increased oxidative tissue damage in adolescent children with depression. This study was registered with the ISRCTN registry (DEPOXIN study, ISRCTN81655012). Full article

(This article belongs to the Special Issue Pathology Analysis on Redox Imbalance in Neurodegenerative Diseases and Neuropsychiatric Disorders)

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