Special Issue "Oxidative Stress and Cancer: The Nrf2 Enigma"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 November 2017).
Interests: microbiology; oncology; therapeutics
Special Issues, Collections and Topics in MDPI journals
Chronic oxidative stress and inflammation are frequently linked to cancer initiation and progression. Oxidative stress signalling is directly associated with the survival and apoptosis of tumor cells, and factors that regulate its homeostasis vs. dysregulation are important tumor biomarkers and targets in cancer therapy. The Nrf2 transcription factor is a master regulator of antioxidant genes, and recent studies demonstrate its crucial role in regulating the cross-talks between metabolic pathways critical in cancer cells. Several Nrf2 inducers are in clinical trials as potent anti-inflammatory agents, but their therapeutic utility against cancers has not been unequivocally shown. Indeed, disparate findings implicate both advantageous and deleterious effects of targeting Nrf2 in aggressive cancer cells. In addition, the identification of Nrf1, and its isoforms, in regulating Nrf2 function; as well as the interaction of Nrf2 with other transcription factors, further underscores the Nrf2 enigma.
The purpose of this Special Issue of Antioxidants will be to highlight the past findings that may further elucidate our understanding of the role of Nrf2 in Cancer, its potential as a biomarker of disease progression and therapeutic outcome, and, last but not the least, the potential safety and drawback of Nrf2 targeted therapy in patients. Therefore, you are invited to submit original research papers or review articles that focus on the role of Nrf2 in Oxidative Stress in cancer cells, and its potential as a disease biomarker and anti-cancer therapy.
Prof. Dr. Debasis Mondal
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Oxidative stress
- Prostate cancer
- Signal transduction
- Nrf2 transcription factor