Dear Colleagues,

Endogenously produced gaseous signaling molecules are a group of ubiquitous small gaseous signaling molecules, which mainly comprise hydrogen sulfide (H₂S), nitric oxide (NO) and carbon monoxide (CO). After in-depth exploration of these gaseous molecules, over the past 30 years, they have been found to have extremely important beneficial effects in innumerable chronic diseases. Reactive oxygen species (ROS) have emerged as principal contributors in a wide range of physiological as well as pathophysiological processes in the vascular system. The enzymatically-generated ROS such as O₂^- and H₂O₂, regulate the functions of the gaseous signaling molecules (H₂S, NO and CO). These gaseous signaling molecules are produced on demand and in recent years it has become evident that they are capable of mediating numerous homeostatic processes within the cardiovascular system such as wound healing, enhanced vasodilation, angiogenesis, and improved vascular function. The regulation of the enzymes which generate H₂S, NO and CO have been shown to be influenced at both the transcriptional as well as the posttranslational levels by redox-dependent mechanisms and are implicated in cellular signaling. Furthermore, the activity and bioavailability of the gaseous signaling molecules themselves are also subject to oxidative modifications.

For this Special Issue of ‘Antioxidants’, we invite you to submit your latest original research findings or a review article which focusses on bringing together the current research concerning the role of endogenous gaseous signaling and their redox regulation in vascular diseases. The original research articles or review articles can include both in vitro and in vivo studies related to the topic. The articles can also highlight about the biological effects, cross-talk among these signaling molecules, and ideas about how these molecules can safely be utilized for therapeutic strategies.

Dr. Cuk-Seong Kim
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• hydrogen sulfide
• nitric oxide
• carbon monoxide
• reactive oxygen species
• cardiovascular diseases
• gaseous signaling