Submit to Antioxidants Review for Antioxidants Propose a Special Issue

Journal Browser

Oxidative Stress and Inflammation: A Mutual Relationship in Cardiometabolic Diseases

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 12906

Share This Special Issue

Special Issue Editors

Dr. Serena Del Turco

E-Mail Website
Guest Editor

Institute of Clinical Physiology, National Research Council (Cnr), via Moruzzi, 1, 56124 Pisa, Italy
Interests: oxidative stress; inflammation; vascular disease; cardiometabolic biomarkers and nanotechnology
Special Issues, Collections and Topics in MDPI journals

Dr. Giuseppina Basta

E-Mail Website
Guest Editor

Institute of Clinical Physiology, National Research Council (Cnr), via Moruzzi, 1, 56124 Pisa, Italy
Interests: inflammation; endothelial dysfunction; atherosclerosis; disease biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress and inflammation are common features of cardiovascular and metabolic diseases. At physiological concentrations, reactive oxygen species (ROS) maintain cell homeostasis regulating several physiological functions, such as cell proliferation, migration, wound healing, angiogenesis, and vasomotor tone. Conversely, a chronic and persistent ROS generation, oxidative stress, mediates detrimental modifications to biomolecules. Oxidative stress can induce tissue injury and the development and progression of an inflammatory state characterized by harmful release of pro-inflammatory mediators. At the same time, specific inflammatory agonists can use ROS as part of their signaling cascades, showing how both processes are tightly interconnected. Oxidative stress and inflammation elicit and orchestrate several signaling pathways that play a crucial role in the pathogenesis of cardiovascular disease, metabolic syndrome, diabetes, obesity, and liver disease.

This Special Issue aims to elucidate the relationship between oxidative stress and inflammation in the pathophysiology and progression of cardiometabolic diseases. We invite researchers to contribute with original papers and reviews that address the identification of novel redox and proinflammatory biomarkers, basic mechanisms, and new approaches to counteract ROS-mediated inflammatory processes in cardiovascular and metabolic diseases.

Dr. Serena Del Turco
Dr. Giuseppina Basta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Oxidative stress
Inflammation
Cell biology
Redox signaling
Inflammasome
Cardiovascular diseases
Metabolic disease
Therapeutic strategies: natural and/or synthetic antioxidants

Published Papers (4 papers)

Download All Papers

Research

Jump to: Review

12 pages, 945 KiB

Open AccessArticle

Interaction of Uric Acid and Neutrophil-to-Lymphocyte Ratio for Cardiometabolic Risk Stratification and Prognosis in Coronary Artery Disease Patients

by Serena Del Turco, Luca Bastiani, Fabrizio Minichilli, Patrizia Landi, Giuseppina Basta, Alessandro Pingitore and Cristina Vassalle

Antioxidants 2022, 11(11), 2163; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11112163 - 31 Oct 2022

Cited by 4 | Viewed by 1580

Abstract

Oxidative stress and inflammation are key factors in cardiometabolic diseases. We set out to evaluate the relationship between serum uric acid (UA) and the neutrophil-to-lymphocyte ratio (NLR) with cardiometabolic risk factors in coronary artery disease (CAD) patients, and their additive and multiplicative interactive effects on outcomes (cardiac death/CD and hard events (HE)—death plus reinfarction). A total of 2712 patients (67 ± 11 years, 1960 males) who underwent coronary angiography was retrospectively analyzed and categorized into no-CAD patients (n = 806), stable-CAD patients (n = 1545), and patients with acute myocardial infarction (AMI) (n = 361). UA and NLR were reciprocally correlated and associated with cardiometabolic risk factors. During a mean follow-up period of 27 ± 20 months, 99 ± 3.6% deaths, and 213 ± 7.8% HE were registered. The Kaplan–Meier survival estimates showed significantly worse outcomes in patients with elevated UA or NLR levels. Multivariate Cox regression analysis demonstrated that NLR independently predicted CD and HE. There was no multiplicative interaction between UA and NLR; however, the use of measures of additive interaction evidenced a positive additive interaction between UA and NLR for CD and HE. Although it is clear that correlation does not imply causation, the coexistence of NRL and UA appears to have a synergistic effect, providing further information for the risk stratification of CAD patients. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation: A Mutual Relationship in Cardiometabolic Diseases)

► Show Figures

Figure 1

12 pages, 1083 KiB

Open AccessArticle

Association between Phytochemical Index and Inflammation in Korean Adults

by Chaehyun Kim and Kyong Park

Antioxidants 2022, 11(2), 348; https://doi.org/10.3390/antiox11020348 - 10 Feb 2022

Cited by 7 | Viewed by 1709

Abstract

While the relationship between phytochemicals and inflammation has been confirmed by in vivo or in vitro studies, large-scale epidemiological studies comprehensively analyzing phytochemical-rich food groups remain scarce. Therefore, we evaluated the association between the phytochemical index (PI) and the inflammation levels in Korean adults. The data were derived from the 2015–2018 Korea National Health and Nutrition Examination Survey, and a total of 18,699 participants were analyzed. High-sensitivity C-reactive protein (hs-CRP) levels >3.0 mg/L and white blood cell (WBC) counts >10 × 10³/μL were defined as “elevated.” The PI was calculated based on eight food groups using a 24-h dietary recall. The odds ratio (OR) and confidence interval (CI) for elevated hs-CRP levels and WBC counts, according to the PI quintile, were calculated using the multivariable logistic regression analysis. Participants in the higher PI group had lower means of hs-CRP levels and WBC counts than those in the lower PI group (all p for trend <0.001). In fully adjusted logistic regression models, elevated hs-CRP levels and WBC counts in the highest PI group were lower by 40% (OR: 0.61, 95% CI: 0.49–0.76) and 34% (OR: 0.66, CI: 0.47–0.93), respectively. Conclusions: A high consumption of phytochemical-rich foods is associated with lower inflammation. This suggests that adopting phytochemical-rich dietary patterns may be an effective approach for reducing inflammation. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation: A Mutual Relationship in Cardiometabolic Diseases)

► Show Figures

Figure 1

14 pages, 2157 KiB

Open AccessArticle

Association of Circulating Heme Oxygenase-1, Lipid Profile and Coronary Disease Phenotype in Patients with Chronic Coronary Syndrome

by Chiara Caselli, Raffaele De Caterina, Rosetta Ragusa, Riccardo Liga, Alessia Gimelli, Arthur J. H. A. Scholte, Aldo Clerico, Juhani Knuuti and Danilo Neglia

Antioxidants 2021, 10(12), 2002; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10122002 - 15 Dec 2021

Cited by 2 | Viewed by 2254

Abstract

Background. The NF-E2–related factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) pathway has an emerging role in atherosclerosis. Activated by oxidative stress, it is deemed to exert athero-protective effects. We aimed at evaluating the relationships between plasma HO-1, clinical/molecular profiles and coronary disease patterns in patients with chronic coronary syndromes (CCS). Methods. HO-1 was measured in 526 patients (60 ± 9 years, 318 males) with CCS. Coronary computed tomography angiography (CTA) and stress imaging were used to assess the disease phenotype (coronary atherosclerosis and myocardial ischemia) in a subgroup of 347 patients. Results. In the overall population, HO-1 median value (25–75 percentile) was 5.195 (1.75–8.25) ng/mL. Patients with higher HO-1 were more frequently male, had a higher BMI and lower LVEF%, but otherwise similar risk factors than the other patients. Their bio-humoral profile was characterized by higher markers of endothelial/myocardial dysfunction, but lower levels of cholesterol lipoproteins. Coronary artery disease was characterized by more diffuse atherosclerosis, with mainly non-obstructive and calcified plaques, and a higher prevalence of functional ischemia. Conclusion: In patients with CCS, higher plasma HO-1 levels are associated with lower cholesterol and a more diffuse but mainly non-obstructive coronary atherosclerosis, confirming a potential role for the Nrf2/HO-1 pathway as a protective feedback. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation: A Mutual Relationship in Cardiometabolic Diseases)

► Show Figures

Figure 1

Review

Jump to: Research

18 pages, 777 KiB

Open AccessReview

Inflammatory Cells in Atherosclerosis

by Marcelle Mehu, Chandrakala Aluganti Narasimhulu and Dinender K. Singla

Antioxidants 2022, 11(2), 233; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox11020233 - 26 Jan 2022

Cited by 38 | Viewed by 6456

Abstract

Atherosclerosis is a chronic progressive disease that involves damage to the intima, inflammatory cell recruitment and the accumulation of lipids followed by calcification and plaque rupture. Inflammation is considered a key mediator of many events during the development and progression of the disease. Various types of inflammatory cells are reported to be involved in atherosclerosis. In the present paper, we discuss the involved inflammatory cells, their characteristic and functional significance in the development and progression of atherosclerosis. The detailed understanding of the role of all these cells in disease progression at different stages sheds more light on the subject and provides valuable insights as to where and when therapy should be targeted. Full article

(This article belongs to the Special Issue Oxidative Stress and Inflammation: A Mutual Relationship in Cardiometabolic Diseases)

► Show Figures