Journal Browser

► Journal Browser

Special Issue Editors

Special Issue Information

Dear Colleagues,

In recent years, the field of tissue regeneration around periodontal and peri-implant tissues has witnessed a lot of advancements, from biomaterial fabrication to the application of tissue engineering. These advancements have not only enhanced regenerative outcomes but also guaranteed better life quality to patients.

In this Special Issue, we welcome original articles (clinical, in vitro, and in vivo studies), reviews (narrative and systematic), and short communications that address the following topics: applications of tissue engineering in periodontal and/or peri-implant tissue regeneration, biomaterial fabrication and coating, 3D printing methods for the manufacturing of 3D printed custom-made scaffolds, use of growth factors, stem cells, gene delivery, epigenetics and extracellular vesicles in periodontal and/or peri-implant tissue regeneration.

Dr. Farah Asa'ad
Dr. Lena Larsson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

tissue engineering
tissue regeneration
periodontal and peri-implant diseases
biomaterials
3D printing
gene delivery
epigenetics
stem cells
growth factors
extracellular vesicles

Published Papers (2 papers)

Download All Papers

Research

Jump to: Review

10 pages, 4246 KiB

Open AccessCommunication

Spatial Controls of Ligamentous Tissue Orientations Using the Additively Manufactured Platforms in an In Vivo Model: A Pilot Study

by Min Guk Kim and Chan Ho Park

Appl. Sci. 2021, 11(17), 7847; https://0-doi-org.brum.beds.ac.uk/10.3390/app11177847 - 26 Aug 2021

Viewed by 1305

Abstract

The periodontal ligaments (PDLs) with specific orientations to tooth-root surfaces play a key role in generating biomechanical responses between the alveolar bone and cementum as a tooth-supporting tissue. However, control of angulations and regeneration of the ligamentous tissues within micron-scaled interfaces remains challenging. To overcome this limitation, this study investigated surface fabrications with microgroove patterns to control orientations of rat PDL cells in vitro and fibrous tissues in vivo. After being harvested, rat PDL cells were cultured and three different microgroove patterns (∠PDL groove = 0°, ∠PDL groove = 45°, and ∠PDL groove = 90°) were created by the digital slicing step in 3D printing. Cell-seeded scaffolds were subcutaneously transplanted at 3 and 6 weeks. In histology images, rat PDL cells were spatially controlled to angularly organize following the microgroove patterns and fibrous tissues were formed in scaffolds with specific angulations, which were reflected by additively manufactured microgroove topographies. Based on the results, specifically characterized surface topographies were significant to directly/indirectly organizing rat PDL cell alignments and fibrous tissue orientations. Therefore, interactions between surface topographies and tissue organizations could be one of the key moderators for the multiple tissue complex (bone-ligament-cementum) neogenesis in periodontal tissue engineering. Full article

(This article belongs to the Special Issue Advances in Tissue Engineering and Biomaterials for Periodontal and Peri-Implant Tissue Regeneration)

► Show Figures

Figure 1

Review

Jump to: Research

23 pages, 445 KiB

Open AccessFeature PaperReview

The Role of Epigenetics in Periodontal and Systemic Diseases and Smoking: A Systematic Review

by Ismael Khouly, Rosalie Salus Braun, Michelle Ordway, Iya Ghassib, Lena Larsson and Farah Asa’ad

Appl. Sci. 2021, 11(11), 5269; https://0-doi-org.brum.beds.ac.uk/10.3390/app11115269 - 06 Jun 2021

Cited by 2 | Viewed by 1757

Abstract

The aims of this systematic review were to identify and synthesize the evidence for an association in DNA methylation/histone modifications between periodontal diseases and systemic diseases/smoking. Electronic database searches using relevant search terms in PubMed, Embase, MEDLINE, CINAHL, Web of Science, Scopus, and SciELO, and manual searches, were independently conducted to identify articles meeting the inclusion criteria. Nine studies of 1482 participants were included. Periodontitis was compared to metabolic disorders, rheumatoid arthritis (RA), cancer, and smokers, as well as healthy controls. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology was found. IL6 and TNF were modified similarly in RA and periodontitis. While TIMP-3 and GSTP-1 were significantly lower in periodontitis patients and controls than in cancer, SOCS-1, RMI2, CDH1, and COX2 were modified similarly in both cancer and periodontitis. While TLR4 in and CXCL8 were affected in periodontitis independent of smoking habit, smoking might change the transcription and methylation states of ECM organization-related genes, which exacerbated the periodontal condition. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal diseases and systemic diseases or smokers compared to healthy patients or non-smokers. Full article

(This article belongs to the Special Issue Advances in Tissue Engineering and Biomaterials for Periodontal and Peri-Implant Tissue Regeneration)

► Show Figures