Antimicrobial Peptides: Synthesis, Properties and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (25 May 2022) | Viewed by 4323

Special Issue Editors


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Guest Editor
Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK
Interests: antimicrobial peptides; membrane proteins; structural biology; protein X-ray crystallography; efflux pumps
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Guest Editor
Department for Science and Environment, Roskilde University, 4000 Roskilde, Denmark
Interests: recombinant protein expression; protein structure; protein biochemistry; molecular biology; microbiology; biochemistry; nanobiotechnology; crystal structure; crystallization; microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The urgency of finding new antimicrobial drugs is obvious if we consider the 10 million premature deaths estimated by 2050 due to antibiotic resistances (AMR) [O’Neill, J. 2014].

Antimicrobial peptides (AMPs) have appeared as an alternative to the commonly used antibiotics due to their antimicrobial, antifungal, and antiviral activities. Widening the knowledge in this field could have a big impact on the AMR issue.

The aim of this Special Issue is to gather scientific articles (research articles, review articles, as well as short communications) related to:

  • New natural AMPs with special properties (e.g. immunomodulatory properties, prevention of the biofilm formation, prevention of post-surgical adhesion);
  • AMPs designed using knowledge of natural AMPs (structure-based, AMP libraries, selective AMPs);
  • Mechanisms of action of AMPs (molecular targets of AMPs, mechanism of membrane disruption);
  • Potential clinical applications of AMPs.

All together, the papers published in this Special Issue should widen our AMP knowledge, serving as inspiration in the discovery of new antibacterial drugs.

Prof. Dr. Enea Sancho-Vaello
Prof. Dr. Kornelius Zeth
Guest Editors

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Keywords

  • Antimicrobial peptides
  • Rational design of peptides
  • Mechanism of action of AMPs
  • Structure of AMPs
  • Antimicrobial activity
  • Biocompatibility assays
  • Molecular targets of AMPs

Published Papers (1 paper)

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Review

16 pages, 3103 KiB  
Review
Harvesting of Antimicrobial Peptides from Insect (Hermetia illucens) and Its Applications in the Food Packaging
by Afreen Sultana, Hongrong Luo and Seeram Ramakrishna
Appl. Sci. 2021, 11(15), 6991; https://0-doi-org.brum.beds.ac.uk/10.3390/app11156991 - 29 Jul 2021
Cited by 13 | Viewed by 3495
Abstract
About one-third of the total food produced is wasted, rising the concern to adopt proper management. Simultaneously with the increase in population, demand for food is increasing which may lead to scarcity. Adequate packaging is one of the ways to avoid deterioration of [...] Read more.
About one-third of the total food produced is wasted, rising the concern to adopt proper management. Simultaneously with the increase in population, demand for food is increasing which may lead to scarcity. Adequate packaging is one of the ways to avoid deterioration of food and prevent wastage. In recent years, active packaging has attained interest due to its commendable results in food preservation. Several studies proved that the embodiment of antimicrobial components into the packaging material has the ability to prevent microbial contamination. Antimicrobial peptides (AMP) are newly discovered antimicrobial agents for impregnation into packaging material. Among various sources for AMP, insects have shown great resistivity against a wide spectrum of microorganisms. Insects feed on substances consisting of a varying range of contaminations, which often results in infections. Insects synthesise AMPs to fight such infections and survive in that atmosphere. The disease-causing agents in humans are the same as those found in insects. Hence, AMPs extracted from insects have the potential to fight the microorganisms that act as hazards to human health. This review highlights the harvesting and synthesis of AMPs from Hermetia illucens, which is a promising source for AMP and its applications in the food packaging industry. Full article
(This article belongs to the Special Issue Antimicrobial Peptides: Synthesis, Properties and Applications)
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