Biodegradable Scaffolds 2021

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 8787

Special Issue Editor

Special Issue Information

Dear Colleagues,

Design of biodegradable scaffolds is indispensable for tissue engineering and organ regeneration. Continued research has been focused to improve characteristics of these artificial templates and to provide similar properties to the living tissues. A wide range of materials have been successfully employed, but ideal compounds have yet to be obtained due to the multiple requirements that remain to be accomplished.  Thus, non-toxicity, non-immunogenicity, maintenance of mechanical integrity prior to regeneration, modulation of cell adhesion, proliferation and differentiation, control of degradation rate and safety of degradation products are some of the main desirable characteristics. Furthermore, additional properties can be easily achieved by incorporating different agents as growth factors that stimulate tissue regeneration and bactericide drugs that avoid infection risk and biofilm formation. Considerable efforts are also being devoted to the design of new technologies able to prepare three-dimensional scaffolds with controlled porosity, pore size, and connectivity.

This Special Issue of Applied Sciences will discuss, collect, and offer recent highlights and advances on the design of new materials including hybrid systems, incorporation of pharmacological agents and development of new processing technologies as ultrasonic micro-molding, melt electrospinning and 3D printing.

Prof. Dr. Jordi Puiggalí
Guest Editor

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Keywords

  • Biodegradable materials
  • Hybrid scaffolds
  • Tissue regeneration
  • Organ regeneration
  • Three dimensional scaffolds
  • Melt electrospinning
  • 3-D printing
  • Ultrasound micromolding

Published Papers (1 paper)

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Review

39 pages, 5678 KiB  
Review
Melt Electrospinning of Polymers: Blends, Nanocomposites, Additives and Applications
by Anna Bachs-Herrera, Omid Yousefzade, Luis J. del Valle and Jordi Puiggali
Appl. Sci. 2021, 11(4), 1808; https://0-doi-org.brum.beds.ac.uk/10.3390/app11041808 - 18 Feb 2021
Cited by 36 | Viewed by 8088
Abstract
Melt electrospinning has been developed in the last decade as an eco-friendly and solvent-free process to fill the gap between the advantages of solution electrospinning and the need of a cost-effective technique for industrial applications. Although the benefits of using melt electrospinning compared [...] Read more.
Melt electrospinning has been developed in the last decade as an eco-friendly and solvent-free process to fill the gap between the advantages of solution electrospinning and the need of a cost-effective technique for industrial applications. Although the benefits of using melt electrospinning compared to solution electrospinning are impressive, there are still challenges that should be solved. These mainly concern to the improvement of polymer melt processability with reduction of polymer degradation and enhancement of fiber stability; and the achievement of a good control over the fiber size and especially for the production of large scale ultrafine fibers. This review is focused in the last research works discussing the different melt processing techniques, the most significant melt processing parameters, the incorporation of different additives (e.g., viscosity and conductivity modifiers), the development of polymer blends and nanocomposites, the new potential applications and the use of drug-loaded melt electrospun scaffolds for biomedical applications. Full article
(This article belongs to the Special Issue Biodegradable Scaffolds 2021)
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