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Applied Sciences
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Biomaterials and Bioimaging: From Biological Tissues to Biomedical Implants
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Biomaterials and Bioimaging: From Biological Tissues to Biomedical Implants

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (20 September 2022) | Viewed by 8403

Special Issue Editors

Dr. Bomi Gweon

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Sejong University, Seoul 05006, Korea
Interests: cell mechanobiology; bioimaging; biomaterials
Dr. Dohyung Lim

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Sejong University, Seoul 05006, Republic of Korea
Interests: implant and scaffold design; biomaterials; total joint arthoplasty; orthopedic biomechanics; bone morphology and mechanics; injury biomechanics; computer simulation; metallography; additive manufacturing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical engineering is a multidisciplinary field that applies principles of chemistry, physics, material science, and mechanical engineering into biology to find and treat diseases. Among various biomedical engineering areas, in particular, significant progress has been made in biomaterial and bioimaging research over the past few decades. Consequently, by leveraging the technologies of these two areas, rapid growth has been made in the field of biomedical engineering. Therefore, in-depth research on biomaterials and bioimaging will have a synergistic effect on understanding human diseases and can facilitate technological advances in preventing, monitoring, and treating diseases.

This Special Issue, “Biomaterials and Bioimaging: From biological tissues to biomedical implants”, will include the latest innovations and emerging developments in biomaterials, bioimaging, and integrative research of these two areas. For example, in the biomaterial area, any topic related to 3D printing, metal implants, bioscaffolds, bioactive surface treatment, tissue engineering, and any new types of materials can be covered. In bioimaging, tissue optics or tomography, multimodal imaging microscopy, molecular imaging and therapies, optical coherence tomography, image analysis methods, and any new types of tissue or cell imaging methods can be included. Most types of articles related to these topics are welcome, including original research articles, brief communications, and review articles. We have the great pleasure of inviting you to contribute research article(s) to this Special Issue.

Dr. Bomi Gweon
Dr. Dohyung Lim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • 3D printing
  • metal implants
  • bioscaffolds
  • bioactive surface treatment
  • tissue engineering
  • bioimaging
  • tissue optics
  • tomography
  • molecular imaging
  • optical coherence tomography
  • multimodal imaging microscopy
  • image analysis method

Published Papers (4 papers)

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Research

13 pages, 2067 KiB  
Article
Enhanced Osteoblast Adhesion and Proliferation on Vacuum Plasma-Treated Implant Surface
by Hyun Jeong Jeon, Ara Jung, Hee Jin Kim, Jeong San Seo, Jun Young Kim, Moon Seop Yum, Bomi Gweon and Youbong Lim
Appl. Sci. 2022, 12(19), 9884; https://0-doi-org.brum.beds.ac.uk/10.3390/app12199884 - 30 Sep 2022
Cited by 4 | Viewed by 2130
Abstract
In this study, we propose a vacuum plasma device for surface treatment of dental implants. This plasma device was designed to allow direct installation of sealed implant packaging containing the dental implant. In this manner, the dental implant could be treated with plasma [...] Read more.
In this study, we propose a vacuum plasma device for surface treatment of dental implants. This plasma device was designed to allow direct installation of sealed implant packaging containing the dental implant. In this manner, the dental implant could be treated with plasma under a moderate vacuum environment while remaining in a sterile condition. To assess the osseointegration efficiency, in vitro experiments using sandblasted, large grit, acid etching (SLA), calcium coated-SLA (CaSLA), and calcium coated-SLA with plasma treatment (PCaSLA) were performed. The implant surface was observed with scanning electron microscope (SEM) before and after plasma treatment. Thereafter, protein adsorption, cell adhesion, proliferation, and differentiation efficiency were investigated on the surface of each implant type using saos-2, an osteoblast. Plasma treatment significantly improved protein adsorption, cell adhesion, and cell proliferation efficiency compared to both CaSLA and SLA without damaging the calcium coating. According to the findings, the proposed vacuum plasma device has shown the potential to improve osseointegration efficiency. We believe that this plasma technology can be an innovative chairside solution that can be easily handled in the clinical field with superb usability. Full article
(This article belongs to the Special Issue Biomaterials and Bioimaging: From Biological Tissues to Biomedical Implants)
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11 pages, 3628 KiB  
Article
Volume and Distribution of Periprosthetic Bone Cysts in the Distal Tibia and Talus before Early Revision of Total Ankle Arthroplasty
by Seoyeong Kim, Jinju Jang, Jae-Hyuk Choi, Hai-Mi Yang, Heoung-Jae Chun, Gun-Woo Lee, Keun-Bae Lee and Dohyung Lim
Appl. Sci. 2021, 11(16), 7242; https://0-doi-org.brum.beds.ac.uk/10.3390/app11167242 - 06 Aug 2021
Cited by 2 | Viewed by 1690
Abstract
Periprosthetic osteolysis is a common complication following total ankle arthroplasty (TAA). However, understanding of osteolysis volume and distribution is still evolving, undermining efforts to reduce the incidence of osteolysis via bone remodeling. We obtained data on the characteristics of osteolysis developing within the [...] Read more.
Periprosthetic osteolysis is a common complication following total ankle arthroplasty (TAA). However, understanding of osteolysis volume and distribution is still evolving, undermining efforts to reduce the incidence of osteolysis via bone remodeling. We obtained data on the characteristics of osteolysis developing within the distal tibia and talus after TAA. Three-dimensional computed tomography (3D-CT) reconstructions of 12 patients who underwent HINTEGRA TAA were performed. We identified 27 volumes of interest (VOIs) in the tibia and talus and used statistical methods to identify the characteristics of osteolysis in the VOIs. The osteolysis volume was significantly larger in the talus than in the tibia (162.1 ± 13.6 and 54.9 ± 6.1 mm3, respectively, p = 0.00). The extent of osteolysis within the peri-prosthetic region was greater than within other regions (p < 0.05). Particularly, in the talus, the region around the talar pegs exhibited 24.2 ± 4.5% more osteolysis than any other talar region (p = 0.00). Our results may suggest that extensive osteolysis within the peri-prosthetic region reflects changes in stress flow and distribution, which vary according to the design and placement of the fixation components. This is the first study to report 3D osteolysis patterns after TAA. Careful planning of TAA design improvements may reduce the incidence of osteolysis. Our results will facilitate the further development of TAA systems. Full article
(This article belongs to the Special Issue Biomaterials and Bioimaging: From Biological Tissues to Biomedical Implants)
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16 pages, 1774 KiB  
Article
Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties
by Gerardo Presbítero, David Gutiérrez, Wendy Ruth Lemus-Martínez, José Félix Vilchez, Pedro García and Ana Arizmendi-Morquecho
Appl. Sci. 2021, 11(12), 5479; https://0-doi-org.brum.beds.ac.uk/10.3390/app11125479 - 13 Jun 2021
Cited by 5 | Viewed by 1940
Abstract
We propose an experimental technique for the estimation of quality parameters of post-mortem human bone samples with signs of osteoporosis. Since we were interested in characterizing bone microstructure by evaluating porosity, trabecular thickness, and space, we obtained reference values of those parameters for [...] Read more.
We propose an experimental technique for the estimation of quality parameters of post-mortem human bone samples with signs of osteoporosis. Since we were interested in characterizing bone microstructure by evaluating porosity, trabecular thickness, and space, we obtained reference values of those parameters for some of our samples through micro-computerized tomography (micro-CT). Nevertheless, as such technology is not widely available, here we used a 2D imaging approximation of those quality parameters. We based our estimation on simple digital microscopy and calibrated to ensure a percentage of similarity higher than 95% in comparison to those values achieved through micro-CT. Additionally, we subjected our samples to mechanical testing to obtain a complete characterization of our samples and to provide a preliminary assessment of the possible relationship between clinical tests of bone mineral density (BMD) and bone quality parameters. Our results show that BMD may have very low specificity in the assessment of the authentic microstructure of bone, then a broader analysis of quality parameters is required to enhance the reliability of future osteoporosis diagnosis technologies. Full article
(This article belongs to the Special Issue Biomaterials and Bioimaging: From Biological Tissues to Biomedical Implants)
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12 pages, 2552 KiB  
Article
Potential Instability and Malfunction of Knee Joints with Vastus Medialis Impairment after Total Knee Arthroplasty
by Yongkyung Lee, Hai-Mi Yang, Jinju Jang, Dai-Soon Kwak, Jungsung Kim, Heoung-Jae Chun, Dukyoung Jung and Dohyung Lim
Appl. Sci. 2021, 11(6), 2764; https://0-doi-org.brum.beds.ac.uk/10.3390/app11062764 - 19 Mar 2021
Cited by 1 | Viewed by 1822
Abstract
Four pairs of fresh-frozen cadaver knees (eight knees, four male knees) with a mean age of 72 ± 7 years were used for tests involving a customized simulator capable of controlling quadriceps loading conditions. The muscle force distribution of the quadriceps for the [...] Read more.
Four pairs of fresh-frozen cadaver knees (eight knees, four male knees) with a mean age of 72 ± 7 years were used for tests involving a customized simulator capable of controlling quadriceps loading conditions. The muscle force distribution of the quadriceps for the normal loading condition was applied on the basis of muscle cross-sectional area data, as previously reported (VM: 31 N; RF/VI: 49 N; VL: 45 N). To simulate vastus medialis (VM) impairment, we set the muscle force for VM in the muscle force distribution of the quadriceps at zero (VM: 0 N; RF/VI: 49 N; VL: 45 N). The joint reaction forces and moments on knee joints that underwent total knee arthroplasty (TKA) did not differ significantly according to VM impairment status for all flexion angles (p > 0.05). Nevertheless, the vectors of internal–external moments mostly showed a tendency for alteration from external to internal due to VM impairment. This tendency was evident in 9 cases in 12 total test pairs (with and without VM impairment). Furthermore, the vectors of the anterior–posterior reaction forces mostly showed a tendency to increase anteriorly due to VM impairment. This tendency was also evident in 9 cases in 12 total test pairs (with and without VM impairment). These results indicate that posterior dislocation of the tibia may be induced if VM impairment occurs after TKA. In conclusion, VM impairment in knee joints undergoing TKA may contribute to posterior dislocation of the tibia by a paradoxical roll-back with enhancements of the anterior joint reaction force and external moment during knee-joint flexion. Our findings may be valuable for understanding the mechanism of potential instability and malfunction due to VM impairment in knee joints after TKA, and may help to optimize clinical/rehabilitation training plans to improve the prognosis (stability and function) of knee joints undergoing TKA. Full article
(This article belongs to the Special Issue Biomaterials and Bioimaging: From Biological Tissues to Biomedical Implants)
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