The Regenerative Engineering of Knee: From Biomaterials to Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 3265

Special Issue Editor

Department of Neuroscience, Section of Human Anatomy, University of Padova, 35121 Padova, Italy
Interests: gross and microscopic anatomy; neuroscience; morphometry; radiology; orthopedics
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Special Issue Information

Dear Colleagues,

Osteoarthritis (OA) is an important cause of disability, representing a significant individual and socioeconomic burden worldwide and, thus, a great challenge for clinicians and researchers in an aging society, with rising levels of obesity. The knee is the mainly affected joint; injuries to articular cartilage and menisci can lead to progressive cartilage degeneration up to OA.

To date, the currently available surgical approaches for cartilage repair (i.e., bone marrow stimulation, grafting, and cell-based techniques for articular cartilage repair) and meniscus reconstruction (i.e., meniscal tear reduction, allografts, implants of synthetic prosthesis) are mainly able to guarantee only short-term relief of symptoms; tissue engineering techniques together with vanguard 3D printing technologies could provide alternative customizable treatment strategies in OA in an era of increasingly personalized medical care.

Dr. Veronica Macchi
Guest Editor

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Keywords

  • Osteoarthritis
  • Tissue engineering
  • 3D bioprinting
  • Biomaterials
  • Stem cells
  • Customized treatments

Published Papers (1 paper)

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Review

18 pages, 1024 KiB  
Review
Viscosupplementation in the Therapy for Osteoarthritic Knee
by Junghyun Park, Hue Jung Park, Min Cheol Rho and Jin Joo
Appl. Sci. 2021, 11(24), 11621; https://0-doi-org.brum.beds.ac.uk/10.3390/app112411621 - 07 Dec 2021
Cited by 6 | Viewed by 2797
Abstract
Osteoarthritis (OA) is a degenerative disease that is spreading worldwide due to an aging population. This is not simply a disease caused by worn out joints, but a complex disease accompanied by various mechanisms such as inflammatory reactions. Among various joints, knee joints [...] Read more.
Osteoarthritis (OA) is a degenerative disease that is spreading worldwide due to an aging population. This is not simply a disease caused by worn out joints, but a complex disease accompanied by various mechanisms such as inflammatory reactions. Among various joints, knee joints show degenerative changes earlier than other joints because they carry most of the weight load, causing social-economic problems. In the case of OA of the knee that does not respond to relatively simple conservative treatments such as physical therapy or medication, intra-articular injection is preferred. However, intra-articular injection drugs have limited effectiveness and uncertainties. There are several intra-articular viscous supplement drugs such as hyaluronic acid. Tissue regeneration active materials such as polydeoxyribonucleotide and polynucleotide are also newly used. The objective of this paper was to compare effects of intra-articular supplementation drugs used for degenerative arthritis of the knee. Full article
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