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Applied Sciences
Special Issues
Biomimetic Smart Materials and Devices in Medicine
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Biomimetic Smart Materials and Devices in Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (10 November 2021) | Viewed by 2162

Special Issue Editor

Prof. Dr. Antonio Apicella

E-Mail Website
Guest Editor
Advanced Material Laboratory, Department of Architecture and Industrial Design, University of Campania, Luigi Vanvitelli, 81031 Aversa, Italy
Interests: smart biomaterials for tissue engineering; ceramo-polymeric hybrid systems; hybrid smart structures; new theoretical approaches for biomimetic material and prostheses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Modern medicine is taking advantage of continuous progresses in biomedical engineering. This Special Issue is dedicated to presenting the most promising recent research advancements of new hybrid and smart materials for biomimetic and bionic devices and innovative biomechanical research approaches, as well as reviewing results from a broad category related to the application of biomedical engineering with new biomimetic metals, ceramics, polymers and their combinations in nanocomposites and hybrid materials.

The aim of this Special Issue is to outline the convergence between clinical applications and biomedical engineering from the perspective of innovative materials science and technologies.

Prof. Dr. Antonio Apicella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metallic smart biomaterials
  • ceramic smart biomaterials
  • polymeric smart biomaterials
  • biomechanics
  • bionics
  • biomimetics
  • nanocomposites
  • hybrid materials
  • bioresorbable ceramics
  • bioresorbable polymers
  • bioresorbable metals
  • polymer composites and nanomaterials
  • ceramic-polymeric hybrid systems
  • hybrid smart structures
  • functional biocoatings
  • new theoretical approaches for biomimetic material and prostheses
  • bionic prostheses based on smart materials
  • shape memory alloys

Published Papers (1 paper)

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Research

22 pages, 2898 KiB  
Article
Bioresorption Control and Biological Response of Magnesium Alloy AZ31 Coated with Poly-β-Hydroxybutyrate
by Lu Wang, Raffaella Aversa, Zhengjun Houa, Jie Tian, Shuang Liang, Shuping Ge, Yu Chen, Valeria Perrotta, Antonio Apicella, Davide Apicella, Luigi Cioffi and Guixue Wang
Appl. Sci. 2021, 11(12), 5627; https://0-doi-org.brum.beds.ac.uk/10.3390/app11125627 - 18 Jun 2021
Cited by 8 | Viewed by 1698
Abstract
Magnesium and its alloys are not normally used as bioresorbable temporary implants due to their high and uncontrolled degradation rate in a physiological liquid environment. The improvement of corrosion resistance to simulated body fluids (SBF) of a magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate [...] Read more.
Magnesium and its alloys are not normally used as bioresorbable temporary implants due to their high and uncontrolled degradation rate in a physiological liquid environment. The improvement of corrosion resistance to simulated body fluids (SBF) of a magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate (PHB) was investigated. Scanning electron microscopy, Fourier transform infrared spectrometer, and contact angle measurements were used to characterize surface morphology, material composition, and wettability, respectively. pH modification of the SBF corroding medium, mass of Mg2+ ions released, weight loss of the samples exposed to the SBF solution, and electrochemical experiments were used to describe the corrosion process and its kinetics. The material’s biocompatibility was described by evaluating the effect of corrosion by products collected in the SBF equilibrating solution on hemolysis ratio, cytotoxicity, nitric oxide (NO), and total antioxidant capacity (T-AOC). The results showed that the PHB coating can diffusively control the degradation rate of magnesium alloy, improving its biocompatibility: the hemolysis rate of materials was lower than 5%, while in vitro human umbilical vein endothelial cell (HUVEC) compatibility experiments showed that PHB-coated Mg alloy promoted cell proliferation and had no effect on the NO content and that the T-AOC was enhanced compared with the normal group and bare AZ31 alloy. PHB-coated AZ31 magnesium alloy extraction fluids have a less toxic behavior due to the lower concentration of corrosion byproducts deriving from the diffusion control exerted by the PHB coating films both from the metal surface to the solution and vice versa. These findings provide more reference value for the selection of such systems as tunable bioresorbable prosthetic materials. Full article
(This article belongs to the Special Issue Biomimetic Smart Materials and Devices in Medicine)
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