Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.5
2.7
Journals
Applied Sciences
Special Issues
Epigenetic and Transcriptional Regulation in Muscle Cells
share announcement

Epigenetic and Transcriptional Regulation in Muscle Cells

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 8095

Special Issue Editors

Dr. Iori Sakakibara

E-Mail Website
Guest Editor
Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School, Tokushima 7708503, Japan
Interests: skeletal muscle; epigenome; transcription
Special Issues, Collections and Topics in MDPI journals
Dr. Shinichiro Hayashi

E-Mail Website
Guest Editor
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan
Interests: skeletal muscle; satellite cell; transcription factor
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to contribute to a Special Issue of the journal Applied Sciences, “Epigenetic and Transcriptional Regulation in Muscle Cells”, which aims to present recent advancements of epigenome analysis in the field of skeletal muscle.

Skeletal muscle is essential for the movement of organisms. Loss of muscle mass and function due to aging, cachexia or genetic diseases decreases health-related quality of life. Today, interest in muscle research is increasing with the growth of the elderly population; moving forward, it is important to study muscles from various points of view, such as development, metabolism, physiology, and pathology. The epigenome provides a basis of transcription via chemical modification of DNA and histones and acts as a cellular memory, regulating a wide range of organism activity. Several applications have already been developed for epigenetic analysis, such as ChIP-seq, ATAC-seq, mass spectrometry, and epigenome editing. These tools are also applicable to skeletal muscles with appropriate adaptation to skeletal muscle traits.

We thus invite you to submit your research on these topics in the form of original research papers, mini-reviews, and perspective articles.

Dr. Iori Sakakibara
Dr. Shinichiro Hayashi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Skeletal muscle
  • Myogenesis
  • Epigenome
  • DNA methylation
  • Histone acetylation
  • Histone methylation
  • Sarcopenia
  • Exercise
  • Cachexia
  • Transcription
  • Muscle atrophy
  • Muscle hypertrophy
  • Satellite cell

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

11 pages, 300 KiB  
Article
Does Acute Caffeine Intake before Evening Training Sessions Impact Sleep Quality and Recovery-Stress State? Preliminary Results from a Study on Highly Trained Judo Athletes
by Aleksandra Filip-Stachnik
Appl. Sci. 2022, 12(19), 9957; https://0-doi-org.brum.beds.ac.uk/10.3390/app12199957 - 03 Oct 2022
Cited by 2 | Viewed by 1790
Abstract
No previous study has analyzed the impact of a low caffeine dose ingested before an evening training session on sleep and recovery-stress state. Nine highly trained judo athletes underwent a randomized, double-blind, placebo-controlled crossover experiment in which each athlete acted as their own [...] Read more.
No previous study has analyzed the impact of a low caffeine dose ingested before an evening training session on sleep and recovery-stress state. Nine highly trained judo athletes underwent a randomized, double-blind, placebo-controlled crossover experiment in which each athlete acted as their own control. Each athlete performed two identical trials after the ingestion of (i) a placebo and (ii) 3 mg of caffeine per kg of body mass, administered 60 min before an evening randori training session. Sleep was assessed using actigraphy and a Karolinska Sleep Diary (KSD), while the recovery-stress state was assessed using a short recovery and stress scale the morning following the trial. No significant differences were observed in any actigraphy sleep measures between conditions, or in the recovery-stress state (p > 0.05 for all). However, sleep quality assessed using the KSD was worse following caffeine ingestion compared with the placebo (3.0 ± 1.0 vs. 3.9 ± 0.6, respectively; p = 0.03, ES: 1.09). The ingestion of 3 mg/kg of caffeine before an evening training session has no impact on actigraphy-derived sleep measures or recovery-stress state. However, it leads to a substantial decrease in self-reported sleep quality. Full article
(This article belongs to the Special Issue Epigenetic and Transcriptional Regulation in Muscle Cells)
11 pages, 371 KiB  
Article
Contribution of Strength, Speed and Power Characteristics to Change of Direction Performance in Male Basketball Players
by Monika Papla, Dawid Perenc, Adam Zając, Adam Maszczyk and Michał Krzysztofik
Appl. Sci. 2022, 12(17), 8484; https://0-doi-org.brum.beds.ac.uk/10.3390/app12178484 - 25 Aug 2022
Cited by 3 | Viewed by 1945
Abstract
This study aimed to investigate the relationships between the modified t−agility test (MAT) time and muscular strength and power of lower limb extensors, adductors (AD), and abductors (AB). Nineteen male basketball players performed: linear sprint tests at 5 m and 20 m, MAT, [...] Read more.
This study aimed to investigate the relationships between the modified t−agility test (MAT) time and muscular strength and power of lower limb extensors, adductors (AD), and abductors (AB). Nineteen male basketball players performed: linear sprint tests at 5 m and 20 m, MAT, countermovement (CMJ) and drop jump (DJ), leg press exercise, AD and AB hip maximum isometric strength measurements. All of them were left leg dominant. The correlation analysis showed a significant, moderate to very large negative relationship between MAT test time initiated to the left and height of CMJ and DJ (r = −0.69 and −0.54; p < 0.01, both), left (r = −0.56; p < 0.01) and right leg (r = −0.41; p < 0.05) AD, left leg AB (r = −0.48; p < 0.05) maximum isometric strength, left (r = −0.72; p < 0.01) and right (r = −0.64; p < 0.01) leg power output in leg press. In the case of the MAT test initiated on the right side first, the correlations were found between CMJ height (r = −0.46; p < 0.05), AD and AB maximum isometric strength of left (r = −0.58 and −0.84; p < 0.01, both) and right leg (r = −0.58 and −0.79; p < 0.01, both), and both legs power output in leg press (r = −0.66 for left and r = −0.59 for right; p < 0.01, both). The regression analyses showed that the prediction model of left leg press peak power, left leg AD maximum isometric strength, and CMJ height could explain up to 93% of the MAT test time initiated to the left first. The model, including left leg AB and AD maximum isometric strength, could explain up to 83% of the MAT test time initiated to the right side first. Findings from this study demonstrate that AB and AD maximum isometric muscle strength are highly related to MAT test performance, which is particularly important when the first turn is performed in the non−dominant direction in this test. Full article
(This article belongs to the Special Issue Epigenetic and Transcriptional Regulation in Muscle Cells)
►▼ Show Figures

Figure 1

11 pages, 523 KiB  
Article
The Effects of a Combined Pre- and Post-Operative Anterior Cruciate Ligament Reconstruction Rehabilitation Program on Lower Extremity Muscle Imbalance
by Krzysztof Ficek, Artur Gołaś, Przemysław Pietraszewski, Magdalena Strózik and Michał Krzysztofik
Appl. Sci. 2022, 12(15), 7411; https://doi.org/10.3390/app12157411 - 23 Jul 2022
Cited by 2 | Viewed by 1807
Abstract
This study examined whether the 5-week pre-operative progressive exercise rehabilitation program with weekly monitoring contributed to a significantly lower muscle activity imbalance in the treatment group, both before and immediately after anterior cruciate ligament reconstruction (ACLR), as well as during the next 5 [...] Read more.
This study examined whether the 5-week pre-operative progressive exercise rehabilitation program with weekly monitoring contributed to a significantly lower muscle activity imbalance in the treatment group, both before and immediately after anterior cruciate ligament reconstruction (ACLR), as well as during the next 5 weeks in comparison to the control group. Twelve professional soccer players took part in the study (from among the top three Polish levels of competition) (age: 26 ± 5 years, body mass: 73 ± 7 kg, stature: 180 ± 6 cm, training experience: 15 ± 4 years). The participants were randomly assigned to the treatment group (n = 6) or to the control group (n = 6). Both groups performed the same pre- and post-operative progressive exercise rehabilitation program, while the rehabilitation of the treatment group was extended by supplementary body-weight functional stabilization training. The three-way repeated-measures ANOVA revealed a statistically significant interaction for muscle × group × time (p < 0.0001; F = 24.897; η2 = 0.806). The post-hoc analysis for the interaction effect of muscle × group × time indicated a significantly higher muscle activity imbalance for every measured muscle in the control group at any time point than in the treatment group (from p = 0.036 to p < 0.0001). The muscle activity imbalance was significantly higher from the 1st to 4th weeks than in the last week before surgery for quadriceps (p < 0.016 for all) and hamstrings (p < 0.001). However, in the case of gluteal muscles’ activity imbalance, it was significantly higher at every time point of the post-operative phase than in the last week before surgery (p < 0.001). The results of this study showed that the 5-week pre-operative rehabilitation program with weekly monitoring influenced outcomes of the post-operative phase. Nevertheless, performing both pre- and post-ACLR rehabilitation significantly reduced the muscle activity imbalance of lower limbs, but in the case of the quadriceps muscles, not to a sufficient level. Full article
(This article belongs to the Special Issue Epigenetic and Transcriptional Regulation in Muscle Cells)
►▼ Show Figures

Figure 1

10 pages, 4864 KiB  
Article
Acute Effects of Different Intensities during Bench Press Exercise on the Mechanical Properties of Triceps Brachii Long Head
by Robert Trybulski, Grzegorz Wojdała, Dan Iulian Alexe, Zuzanna Komarek, Piotr Aschenbrenner, Michał Wilk, Adam Zając and Michał Krzysztofik
Appl. Sci. 2022, 12(6), 3197; https://0-doi-org.brum.beds.ac.uk/10.3390/app12063197 - 21 Mar 2022
Cited by 13 | Viewed by 1935
Abstract
This study aimed to analyze acute changes in the muscle mechanical properties of the triceps brachii long head after bench press exercise performed at different external loads and with different intensities of effort along with power performance. Ten resistance-trained males (age: 27.7 ± [...] Read more.
This study aimed to analyze acute changes in the muscle mechanical properties of the triceps brachii long head after bench press exercise performed at different external loads and with different intensities of effort along with power performance. Ten resistance-trained males (age: 27.7 ± 3.7 yr, body mass: 90.1 ± 17.1 kg, height: 184 ± 4 cm; experience in resistance training: 5.8 ± 2.6 yr, relative one-repetition maximum (1RM) in the bench press: 1.23 ± 0.22 kg/body mass) performed two different testing conditions in a randomized order. During the experimental session, participants performed four successive sets of two repetitions of the bench press exercise at: 50, 70, and 90% 1RM, respectively, followed by a set at 70% 1RM performed until failure, with a 4 min rest interval between each set. Immediately before and after each set, muscle mechanical properties of the dominant limb triceps brachii long head were assessed via a Myoton device. To determine fatigue, peak and average barbell velocity were measured at 70% 1RM and at 70% 1RM until failure (only first and second repetition). In the control condition, only muscle mechanical properties at the same time points after the warm-up were assessed. The intraclass correlation coefficients indicated “poor” to “excellent” reliability for decrement, relaxation time, and creep. Therefore, these variables were excluded from further analysis. Three-way ANOVAs (2 groups × 2 times × 4 loads) indicated a statistically significant group × time interaction for muscle tone (p = 0.008). Post hoc tests revealed a statistically significant increase in muscle tone after 70% 1RM (p = 0.034; ES = 0.32) and 90% 1RM (p = 0.011; ES = 0.56). No significant changes were found for stiffness. The t-tests indicated a significant decrease in peak (p = 0.001; ES = 1.02) and average barbell velocity (p = 0.008; ES = 0.8) during the first two repetitions of a set at 70% 1RM until failure in comparison to the set at 70% 1RM. The results indicate that low-volume, high-load resistance exercise immediately increases muscle tone but not stiffness. Despite no significant changes in the mechanical properties of the muscle being registered simultaneously with a decrease in barbell velocity, there was a trend of increased muscle tone. Therefore, further studies with larger samples are required to verify whether muscle tone could be a sensitive marker to detect acute muscle fatigue. Full article
(This article belongs to the Special Issue Epigenetic and Transcriptional Regulation in Muscle Cells)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop