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Applied Sciences
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Effect of Bioactive Substances Extracted from Food on Human Health
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Effect of Bioactive Substances Extracted from Food on Human Health

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: closed (10 September 2021) | Viewed by 4396

Special Issue Editor

Prof. Dr. Beniamino Palmieri

E-Mail Website
Guest Editor
Surgery Department, University of Modena, Via del Pozzo, 71, 41124 Modena, Italy
Interests: clinical research; bioactive substances; human health

Special Issue Information

Dear Colleagues,

The Hippocratic statement “Let food be thy medicine” still sounds outstanding today and people continually find the healthy and therapeutics properties of food more appealing than chemical drugs whose action mechanism is supposed to be unnatural and somehow “artificial”. As to the concept of bioactive substances, we rely on compounds that interact with organs and functions of living beings with a variety of physiologic effects in health and diseases. They can be found in fats, carbohydrates, protein, vitamins, and minerals. The new challenge is to supply these bioactive nutrients from the food chain through a process that can optimize bioavailability and utilization in a preventive and curative setting, starting from fresh nutrients.

Lycopene, a potent antioxidant carotenoid in tomatoes and other fruits, for example, is thought to protect against prostate and other cancers, and to inhibit tumor cell growth in animals. It has anti-carcinogenic actions in experimental models, as well as cardio-protective effects.

Food-derived peptides from casein, fish muscle, and plant protein hydrolysates also display several cardiovascular and digestive properties. The bifunctional extracts of cannabis have been extensively studied for their effects against cancer and also cardiovascular disease and this has led to new perspectives of the nervous system, with the discovery of a specific cannabinoid network and also strong antioxidant effects and anti-cancer actions in cannabinoid receptors.

This Special Issue, dedicated to human health and bioactive substances extracted from food, is open to authors that wish to share their experience of this fascinating issue either with technical, experimental, or clinical contributions to expand the science branch and recruit further intellectual and financial resources for the wellbeing and care of humanity.

Prof. Dr. Beniamino Palmieri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Food
  • cancer
  • cannabis
  • lycopene
  • wellbeing
  • fresh nutrient

Published Papers (2 papers)

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Research

10 pages, 3267 KiB  
Article
A Synergistic Anti-Diabetic Effect by Ginsenosides Rb1 and Rg3 through Adipogenic and Insulin Signaling Pathways in 3T3-L1 Cells
by Hee-Do Hong, Sun-Il Choi, Ok-Hwan Lee and Young-Cheul Kim
Appl. Sci. 2021, 11(4), 1725; https://0-doi-org.brum.beds.ac.uk/10.3390/app11041725 - 15 Feb 2021
Cited by 1 | Viewed by 1938
Abstract
Although ginsenosides Rb1 and Rg3 have been identified as the significant ginsenosides found in red ginseng that confer anti-diabetic actions, it is unclear whether insulin-sensitizing effects are mediated by the individual compounds or by their combination. To determine the effect of ginsenosides Rb1 [...] Read more.
Although ginsenosides Rb1 and Rg3 have been identified as the significant ginsenosides found in red ginseng that confer anti-diabetic actions, it is unclear whether insulin-sensitizing effects are mediated by the individual compounds or by their combination. To determine the effect of ginsenosides Rb1 and Rg3 on adipocyte differentiation, 3T3-L1 preadipocytes were induced to differentiate the standard hormonal inducers in the absence or presence of ginsenosides Rb1 or Rg3. Additionally, we determined the effects of Rb1, Rg3, or their combination on the expression of genes related to adipocyte differentiation, adipogenic transcription factors, and the insulin signaling pathway in 3T3-L1 cells using semi-quantitative RT-PCR. Rb1 significantly increased the expression of CEBPα, PPARγ, and aP2 mRNAs. However, Rg3 exerted its maximal stimulatory effect on these genes at 1 μM concentration, while a high concentration (50 μM) showed inhibitory effects. Similarly, treatment with Rb1 and Rg3 (1 μM) increased the expression of IRS-1, Akt, PI3K, GLUT4, and adiponectin. Importantly, co-treatment of Rb1 and Rg3 (9:1) induced the maximal expression levels of these mRNAs. Our data indicate that the anti-diabetic activity of red ginseng is, in part, mediated by synergistic actions of Rb1 and Rg3, further supporting the significance of minor Rg3. Full article
(This article belongs to the Special Issue Effect of Bioactive Substances Extracted from Food on Human Health)
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11 pages, 5807 KiB  
Article
Natural Extracts from White Common Bean (Phaseolus vulgaris L.) Inhibit 3T3-L1 Adipocytes Differentiation
by Zhenxing Shi, Xin Zhang, Yingying Zhu, Yang Yao and Guixing Ren
Appl. Sci. 2021, 11(1), 167; https://0-doi-org.brum.beds.ac.uk/10.3390/app11010167 - 26 Dec 2020
Cited by 8 | Viewed by 2059
Abstract
Background: Recent studies have shown that the consumption of common bean (Phaseolus vulgaris L.) foods plays an essential role in the prevention and treatment of obesity. Methods: In this study, different natural extracts that include common bean polyphenol-rich extract (CBP), α-amylase inhibitor-rich [...] Read more.
Background: Recent studies have shown that the consumption of common bean (Phaseolus vulgaris L.) foods plays an essential role in the prevention and treatment of obesity. Methods: In this study, different natural extracts that include common bean polyphenol-rich extract (CBP), α-amylase inhibitor-rich extract (α-AIE), and non-starch polysaccharides-rich extract (NSP) were isolated. Their effects on 3T3-L1 adipocytes differentiation were evaluated, respectively. Results: The results showed that CPB reduced the lipid content in the mature adipocytes to 79.29% (150 μg/mL) and 35.13% (300 μg/mL), and α-AIE reduced it to 90.20% (2 mg/mL) and 68.28% (4 mg/mL), while NSP exhibited an auxo-action, suggesting that both CBP and a-AIE inhibited 3T3-L1 adipocytes differentiation. Additionally, CBP significantly suppressed (p < 0.05) the mRNA expression level and the protein expression level of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), sterol-regulatory element binding proteins 1 c (SREBP-1c), lipoprotein lipase (LPL), and fatty acid binding protein (ap2). Meanwhile, α-AIE only showed significant suppression effects on PPARγ, C/EBPα, and ap2 at the high dose of 4 mg/mL (p < 0.05). Conclusions: These findings indicate that CBP, from white common bean, might be the major component responsible for the inhibitory effects on adipocyte differentiation. Full article
(This article belongs to the Special Issue Effect of Bioactive Substances Extracted from Food on Human Health)
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