Gene Expression and Regulation during Embryonic Development

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 2589

Special Issue Editors

Helmholtz Pioneer Campus (HPC), Helmholtz Zentrum München, 85764 Neuherberg, Germany
Interests: aging; development; single-cell omics; regulation of gene expression; genomics; epigenetics; metabolism; cell biology; next-generation sequencing; liver
Department of Animal Production and Health, Veterinary Public Health and Food Science and Technology (PASAPTA), Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46113 Valencia, Spain
Interests: companion animals; molecular biology; molecular genetics; oncology
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Special Issue Information

Dear Colleagues,

Embryonic development is a complex process in which changes in cell expression programs will determine different cell lineages from zygote to embryo. In females, the crosstalk between the corpora lutea and the endometrium plays a key role in embryonic, pre-implantation, and fetal stages. During the embryonic stage, the precise sequence of genomic events that determine the coordinated cell fate and tissue development still remains unknown. This Special Issue aims to shed light on most recent discoveries on how gene expression programs are in synchrony among individual cells, leading to the successful implantation process. Manuscripts on regulation of gene expression, including changes in the transcriptome and the epigenome in the embryo and endometrial tissues will be invited in this Special Issue. A particular focus on single-cell omics and multiomics will be considered, as well as other novel technologies that are advancing our understanding in the temporal and spatial organization of developmental cues. We envision that a comparison of embryo development across species will open new opportunities to advance our understanding of the molecular architecture and lineage specification of the developmental processes; therefore, we will also consider techniques focused on improving implantation rates in humans and other mammals.

Dr. Celia Pilar Martinez-Jimenez
Dr. María Dolores Llobat Bordes
Guest Editors

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Keywords

  • Gene expression
  • Gene regulation
  • Implantation
  • Reproduction
  • Mammals
  • Single-cell omics

Published Papers (1 paper)

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Review

12 pages, 341 KiB  
Review
Impact of Environmental Stressors on Gene Expression in the Embryo of the Italian Wall Lizard
by Rosaria Scudiero, Chiara Maria Motta and Palma Simoniello
Appl. Sci. 2021, 11(11), 4723; https://0-doi-org.brum.beds.ac.uk/10.3390/app11114723 - 21 May 2021
Cited by 2 | Viewed by 1809
Abstract
The cleidoic eggs of oviparous reptiles are protected from the external environment by membranes and a parchment shell permeable to water and dissolved molecules. As a consequence, not only physical but also chemical insults can reach the developing embryos, interfering with gene expression. [...] Read more.
The cleidoic eggs of oviparous reptiles are protected from the external environment by membranes and a parchment shell permeable to water and dissolved molecules. As a consequence, not only physical but also chemical insults can reach the developing embryos, interfering with gene expression. This review provides information on the impact of the exposure to cadmium contamination or thermal stress on gene expression during the development of Italian wall lizards of the genus Podarcis. The results obtained by transcriptomic analysis, although not exhaustive, allowed to identify some stress-reactive genes and, consequently, the molecular pathways in which these genes are involved. Cadmium-responsive genes encode proteins involved in cellular protection, metabolism and proliferation, membrane trafficking, protein interactions, neuronal transmission and plasticity, immune response, and transcription regulatory factors. Cold stress changes the expression of genes involved in transcriptional/translational regulation and chromatin remodeling and inhibits the transcription of a histone methyltransferase with the probable consequence of modifying the epigenetic control of DNA. These findings provide transcriptome-level evidence of how terrestrial vertebrate embryos cope with stress, giving a key to use in population survival and environmental change studies. A better understanding of the genes contributing to stress tolerance in vertebrates would facilitate methodologies and applications aimed at improving resistance to unfavourable environments. Full article
(This article belongs to the Special Issue Gene Expression and Regulation during Embryonic Development)
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