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Applied Sciences
Special Issues
Extracellular Matrix Peptides – Matrikines
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Extracellular Matrix Peptides – Matrikines

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 6975

Special Issue Editors

Dr. Konrad A. Szychowski

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Guest Editor
Department of Lifestyle Disorders and Regenerative Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland
Interests: neurobiology; neurotoxicology; xenobiotics; elastin-derived peptides; extracellular matrix proteins
Prof. Dr. Jan Gmiński

E-Mail Website1 Website2
Co-Guest Editor
Department of Lifestyle Disorders and Regenerative Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland
Interests: elastin-derived peptides; extracellular matrix proteins; clinical biochemistry; laboratory diagnostics; applied medicine

Special Issue Information

Dear Colleagues,

The extracellular matrix, which is one of the most important components of an organism, has been regarded as metabolically passive for many years. In fact, it serves several functions, i.e., formation of the parenchymal stroma, nutrient supply to organs, and regulation of cell, and tissue functions. It is composed of many proteins, proteoglycans, polymeric oligosaccharides, and water. Collagen and elastin are its most important proteins. Peptides originating from the fragmentation of extracellular matrix proteins – matrikines – have an important role in human biology.

This Special Issue entitled “Extracellular Matrix Peptides – Matrikines” will publish a selection of recent research articles, short communications, reviews, and perspectives in the area of bioactive peptides from the extracellular matrix. We warmly invite you to submit a publication related to the list of keywords.

Dr. Konrad A. Szychowski
Prof. Dr. Jan Gmiński
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular matrix proteins
  • matrikines
  • matrisome
  • matricryptins
  • collagen-derived peptides
  • FACIT
  • elastin-derived peptides
  • elastin-like polypeptides
  • elastokines
  • VGVAPG
  • fibronectin peptides
  • laminin peptides
  • bioconjugates
  • synthetic peptides

Published Papers (2 papers)

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Review

8 pages, 5397 KiB  
Review
Review of the Relationship between Reactive Oxygen Species (ROS) and Elastin-Derived Peptides (EDPs)
by Konrad A. Szychowski and Bartosz Skóra
Appl. Sci. 2021, 11(18), 8732; https://0-doi-org.brum.beds.ac.uk/10.3390/app11188732 - 18 Sep 2021
Cited by 7 | Viewed by 1905
Abstract
Reactive oxygen species (ROS) are central elements of a number of physiological processes such as differentiation and intracellular signaling, as well as pathological processes, e.g., inflammation or apoptosis. ROS are involved in the growth and proliferation of stem cells, cell communication, cell aging, [...] Read more.
Reactive oxygen species (ROS) are central elements of a number of physiological processes such as differentiation and intracellular signaling, as well as pathological processes, e.g., inflammation or apoptosis. ROS are involved in the growth and proliferation of stem cells, cell communication, cell aging, all types of inflammation, cancer development and proliferation, or type 2 diabetes. Elastin-derived peptides (EDPs) are detected in all these conditions and, according to the current state of knowledge, the role of the extracellular matrix (ECM) protein is crucial. It is believed that EDPs are a result of the aforementioned pathological conditions and are generated during degradation of ECM. However, as shown in the literature, the production of EDPs can be induced not only by inter alia chemical, enzymatic, and physical factors but also directly by ROS. No comprehensive study of the impact of ROS on EDPs and EDPs on ROS production has been conducted to date; therefore, the aim of this paper is to summarize the current state of knowledge of the relationship between ROS and ECM with special involvement of EDPs in the processes mentioned above. Depending on the type of cells, tissue, or organism, the relationships between ROS and ECM/EDPs may differ completely. Full article
(This article belongs to the Special Issue Extracellular Matrix Peptides – Matrikines)
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13 pages, 369 KiB  
Review
Collagenases MMP-1, MMP-13, and Tissue Inhibitors TIMP-1, TIMP-2: Their Role in Healthy and Complicated Pregnancy and Potential as Preeclampsia Biomarkers—A Brief Review
by Asparuh Nikolov, Nikola Popovski and Irena Hristova
Appl. Sci. 2020, 10(21), 7731; https://0-doi-org.brum.beds.ac.uk/10.3390/app10217731 - 31 Oct 2020
Cited by 9 | Viewed by 4203
Abstract
Extracellular matrix (ECM) turnover is characterized by a unique balance between matrix metalloproteinases’ degradation activity and their natural inhibition by collagen specific tissue inhibitors. Human uterine ECM is a complex structure, majorly consisting of proteins as fibrillar collagen types I and III, fibronectin, [...] Read more.
Extracellular matrix (ECM) turnover is characterized by a unique balance between matrix metalloproteinases’ degradation activity and their natural inhibition by collagen specific tissue inhibitors. Human uterine ECM is a complex structure, majorly consisting of proteins as fibrillar collagen types I and III, fibronectin, and laminin. Collagenases are enzymes from the matrix metalloproteinases’ family, which are predominantly involved in fibrillar collagen types I and III degradation. They are mainly represented by matrix metalloproteinase-1, -13 (MMP-1, -13), naturally inhibited by tissue inhibitors (TIMP-1, -2). The collagen structure of the uterus has been shown to be impaired in women with preeclampsia. This is a result of MMPs/TIMPs dysregulation interplay. This review article summarizes the actual available research data in the literature about the role of MMP-1, MMP-13 and TIMP-1, and TIMP-2 in collagen types I and III turnover in healthy and complicated pregnancy. Their potential use as circulating markers for diagnosis, prognosis, and monitoring of the development of preeclampsia is discussed as well. Full article
(This article belongs to the Special Issue Extracellular Matrix Peptides – Matrikines)
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