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Applied Sciences
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Nanotechnology for Early Diagnosis and Improving Oral Health
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Nanotechnology for Early Diagnosis and Improving Oral Health

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 7932

Special Issue Editors

Dr. Corina Marilena Cristache

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Guest Editor
Department of Dental Techniques, “Carol Davila” University of Medicine and Pharmacy, 8, Eroilor Sanitari Blvd, 050474 Bucharest, Romania
Interests: nanomaterials; oral and maxillofacial surgery; CAD/CAM; 3D printing; implant dentistry; biomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Liliana Burlibasa

E-Mail Website1 Website2
Guest Editor
Genetics Department, University of Bucharest, 1 Intr. Portocalilor, 060101 Bucharest, Romania
Interests: genotoxicity; nanomaterials; epigenetics.
Prof. Dr. Eugenia Eftimie Totu

E-Mail Website
Guest Editor
University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science, 1-5 Polizu Str., 11061 Bucharest, Romania
Interests: nanotechnology; analytical chemistry; chemical sensors; thermal analysis; AC impedance spectroscopy

Special Issue Information

Dear Colleagues,

Nanotechnology, referring to the development or application of particles with dimensions in the nanometer range, revolutionized the biomedical and dental field by improving mechanical and physical properties of materials, introducing new diagnostic modalities and targeted drug nano-delivery systems, as well as preventing diseases, and, therefore, improving oral health.

The incorporation of nanotechnology for the prevention and treatment of oral disease has enormous potential for enhancing the properties and mechanisms of action of currently available materials and therapeutics, or the development of novel therapeutics, or preventing oral diseases.

This Special Issue is focused on the use of nanotechnology and nanostructured materials in all fields of dentistry

Topics include, but are not limited to the following:

-  Nanostructured dental materials with improved properties used in prosthodontics, restorative dentistry, and endodontics;

- Nanostructured materials in preventive dentistry;

- Application of nanotechnologies and nanomaterials in diagnosis;

- Improved nanostructures of dental implants surface for fast osseointegration and prevention of bone loss and preimplant disease;

- Nanostructured materials for topical treatment in periodontal disease;

- Nanostructured materials for regenerative dentistry;

- Nanomaterials safety: cytotoxicity, genotoxicity, and health hazards;

- Green nanotechnology and environmental sustainability.

We hope that new ideas will promote the fast development of this exciting topic and we invite you to submit your contributions to this Special Issue with the best of your research activities.

DMD, Ph.D., Dr. Habil., Assoc. Prof. Corina Marilena Cristache
Dr. Liliana Burlibasa
Prof. Dr. Eugenia Eftimie Totu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanostructure
  • nanodentistry
  • dental materials
  • prophylaxis
  • periodontal disease
  • nanoparticles
  • nanotechnology
  • toxicity
  • risk assessment.

Published Papers (3 papers)

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Research

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12 pages, 4227 KiB  
Article
Anticancer Efficacy of Nonthermal Plasma Therapy Combined with PD-L1 Antibody Conjugated Gold Nanoparticles on Oral Squamous Cell Carcinoma
by Jinyoung Park, Yoon-Seo Jang, Jeong-Hae Choi, Miheon Ryu, Gyoo-Cheon Kim, June-Ho Byun, Dae-Seok Hwang and Uk-Kyu Kim
Appl. Sci. 2021, 11(10), 4559; https://0-doi-org.brum.beds.ac.uk/10.3390/app11104559 - 17 May 2021
Cited by 5 | Viewed by 1889
Abstract
Combination therapies for the treatment of oral squamous cell carcinoma have been studied extensively and represent a synergistic approach with better outcomes than monotherapy. In this study, a novel combination therapy was investigated using gold nanoparticles (GNP) conjugated to programmed cell death protein [...] Read more.
Combination therapies for the treatment of oral squamous cell carcinoma have been studied extensively and represent a synergistic approach with better outcomes than monotherapy. In this study, a novel combination therapy was investigated using gold nanoparticles (GNP) conjugated to programmed cell death protein ligand 1 (PD-L1) antibodies and nonthermal plasma (NTP). The present study describes the effectiveness of NTP using PD-L1 antibody conjugated to GNP in PD-L1 expressing SCC-25 cells, an oral squamous cell carcinoma line. Immunocytochemistry revealed higher levels of PD-L1 expression and an increase in the selective uptake of PD-L1 antibody + GNP on SCC-25 cells compared to HaCaT cells. In addition, cell viability analyses confirmed higher levels of cell death of SCC-25 cells after treatment with PD-L1 antibody, GNP, and NTP compared to HaCaT cells. Among the experimental groups, the highest cell death was observed upon treatment with PD-L1 antibody + GNP + NTP. Following the Western blot analysis and immunofluorescence staining, the expression of apoptosis-related proteins was found to increase after treatment with PD-L1 antibody + GNP + NTP among the other experimental groups. In conclusion, the treatment of SCC-25 cells with PD-L1 antibody + GNP + NTP significantly increased the number of dead cells compared to other experimental groups. The results of this in vitro study confirmed the therapeutic effects of PD-L1 antibody + GNP + NTP treatment on oral squamous cell carcinoma. Full article
(This article belongs to the Special Issue Nanotechnology for Early Diagnosis and Improving Oral Health)
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14 pages, 2707 KiB  
Article
Are Nano TiO2 Inclusions Improving Biocompatibility of Photocurable Polydimethylsiloxane for Maxillofacial Prosthesis Manufacturing?
by Eugenia Eftimie Totu, Corina Marilena Cristache, Viorel Stefan Perieanu, Mihai Burlibasa, Daniel Costinel Petre and Liliana Burlibasa
Appl. Sci. 2021, 11(9), 3777; https://0-doi-org.brum.beds.ac.uk/10.3390/app11093777 - 22 Apr 2021
Cited by 7 | Viewed by 2362
Abstract
(1) Background: The development of a biocompatible material for direct additive manufacturing of maxillofacial extraoral prosthesis is still a challenging task. The aim of the present study was to obtain a photocurable PDMS, with nano TiO2 inclusions, for directly 3D printing of [...] Read more.
(1) Background: The development of a biocompatible material for direct additive manufacturing of maxillofacial extraoral prosthesis is still a challenging task. The aim of the present study was to obtain a photocurable PDMS, with nano TiO2 inclusions, for directly 3D printing of extraoral, maxillofacial prosthesis. The biocompatibility of the newly obtained nanocomposite was also investigated; (2) Methods: 2.5% (m/m) titania nanoparticles (TiO2) oxide anatase and a photoinitiator, benzophenone (BF) 4.5% were added to commercially available PDMS for maxillofacial soft prostheses manufacturing. The three different samples (PDMS, PDMS-BF and PDMS-BF-TiO2) were assessed by dielectric curing analysis (DEA) based on their viscosities and curing times. In vitro micronucleus test (MNvit) was performed for genotoxicity assessment and three concentrations of each compounds (2 mg/L, 4 mg/L and 8 mg/L) were tested in duplicate and compared to a control; (3) Results: The nanocomposite PDMS-BP-TiO2 was fully reticulated within a few minutes under UV radiation, according to the dielectric analysis. PDMS-BF-TiO2 nanocomposite showed the lowest degree of cyto- and genotoxicity; (4) Conclusions: In the limits of the present study, the proposed ex situ preparation of a PDMS-BP-TiO2 offers an easy, simple, and promising technique that could be successfully used for 3D printing medical applications. Full article
(This article belongs to the Special Issue Nanotechnology for Early Diagnosis and Improving Oral Health)
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Review

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26 pages, 2921 KiB  
Review
Emergence of Nano-Dentistry as a Reality of Contemporary Dentistry
by Orest Kochan, Svitlana Boitsaniuk, Mariana Levkiv, Krzysztof Przystupa, Nadiia Manashchuk, Khrystyna Pohoretska, Natalia Chornij, Iryna Tsvyntarna and Liudmyla Patskan
Appl. Sci. 2022, 12(4), 2008; https://0-doi-org.brum.beds.ac.uk/10.3390/app12042008 - 15 Feb 2022
Cited by 7 | Viewed by 3035
Abstract
(1) Background. Nanotechnology offers significant alternative ways to solve scientific, medical, and human health issues. Dental biomaterials were improved by nanotechnology. It manufactures better materials or improves the existing ones and forms the basis of novel methods for disease diagnosis and prevention. Modern [...] Read more.
(1) Background. Nanotechnology offers significant alternative ways to solve scientific, medical, and human health issues. Dental biomaterials were improved by nanotechnology. It manufactures better materials or improves the existing ones and forms the basis of novel methods for disease diagnosis and prevention. Modern nanotechnology makes oral health care services more acceptable for patients. Nanotechnology is now important area of research, covering a broad range of applications in dentistry. (2) Methods. Relevant literature from Scopus published in English was selected using the keywords “nanoparticle” and “dentistry”. To the selected articles we applied the inclusion and exclusion criteria to choose the relevant ones. (3) Results. Based on the relevant articles, a literature review was prepared. This review provides an insight into the applications of nanotechnology in various branches of dentistry. We applied several regression models to fit number of papers versus time and chose the best one. We used it to construct the forecast and its 95%-confidence interval for the number of publications in 2022–2026. (4) Conclusions. It shows that a significant rise in papers is expected. This review familiarizes dentists with properties and benefits of nanomaterials and nanotechnology. Additionally, it can help scientists to consider the direction of their research and to plan prospective research projects. Full article
(This article belongs to the Special Issue Nanotechnology for Early Diagnosis and Improving Oral Health)
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