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Applied Sciences
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Oral Bone Disease and Bone Regenerative Therapy for Dental Implants
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Oral Bone Disease and Bone Regenerative Therapy for Dental Implants

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 8395

Special Issue Editors

Prof. Dr. Roberto Sacco

E-Mail Website
Guest Editor
Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester M13 9PL, UK
Interests: dental implants; bone healing histology and histomorphometry; autologous bone regeneration; homologues bone regeneration; clinical research; iatrogenic oral bone disease
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julian Yates

E-Mail Website
Guest Editor
Division of Dentistry, School of Medical Sciences, University of Manchester, Manchester M13 9PL, UK
Interests: facial deformity; facial trauma; oral and maxillofacial implantology; soft and hard tissue augmentation/grafting and trigeminal nerve repair
Prof. Dr. Mônica Diuana Calasans-Maia

E-Mail Website
Guest Editor
Oral Surgery Department, Universidade Federal Fluminense, Niteroi 24020-140, Brazil
Interests: PCR cell culture; immunohistochemistry; biomaterials; clinical trials; biocompatibility; animal models; platelets; hydroxyapatites; dental surgery

Special Issue Information

Dear Colleagues,

Unlike other kinds of tissues, bone has the ability to repair and regenerate itself. However, large bone defects, insufficient blood supply, infection, and systemic disease can negatively influence its inner abilities.

Bone tissue engineering aims to repair, restore, and regenerate lost or damaged bone tissues using isolated or combined biomaterials, cells, and factors (chemical and biological). One of the goals in bone tissue engineering is to develop biocompatible materials capable of accelerating the repair of bone diseases and bone loss from trauma and aging while ensuring the functionality and mechanical structure of the new-formed bone.

Nanostructured and bioactive biomaterials have been highlighted as strategic elements for regenerative medicine due to their large specific area, its characteristic of acting as carrier vehicles, and the release of growth factors, cells, and drugs. These characteristics potentiate the bioabsorption of the material and its efficiency in tissue regeneration, as well as its use as a nanocarrier of biomolecules (proteins, peptides, growth factors, and drugs). Although significant progress has been made in this field, challenges remain regarding the treatment of bone diseases such as bone infections caused by drugs and recovery of lost bone for subsequent prosthetic rehabilitation on dental implants. 

Prof. Dr. Roberto Sacco
Prof. Dr. Julian Yates
Prof. Dr. Mônica Diuana Calasans-Maia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone disease
  • ORN
  • osteomyelitis
  • MRONJ
  • bone regeneration
  • dental implants
  • bone substitute
  • preclinical study
  • clinical trials

Published Papers (4 papers)

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Review

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17 pages, 1310 KiB  
Review
A Comprehensive Quality Meta-Review of Genetic and Pharmacogenomic Aspects of Medication-Related Osteonecrosis of The Jaw (MRONJ)
by Roberto Sacco, Sergio Olate, Monica Diuana Calasans-Maia, Nicola Sacco, Alessandro Acocella, Carlos Fernando De Almeida Barros Mourão, Vittorio Moraschini, Oladapo Akintola, Raphael Capelli Guerra and Julian Yates
Appl. Sci. 2022, 12(23), 12289; https://0-doi-org.brum.beds.ac.uk/10.3390/app122312289 - 01 Dec 2022
Viewed by 1229
Abstract
Background: Antiresorptive and antiangiogenic medications can cause a serious adverse effect known as medication-related osteonecrosis of the jaw (MRONJ). In recent years, a new trend of research has emerged emphasizing the potential relation of MRONJ and genetic predisposition. Current evidence-based science of [...] Read more.
Background: Antiresorptive and antiangiogenic medications can cause a serious adverse effect known as medication-related osteonecrosis of the jaw (MRONJ). In recent years, a new trend of research has emerged emphasizing the potential relation of MRONJ and genetic predisposition. Current evidence-based science of this adverse reaction is associated with poorly performed studies. Additionally, MRONJ research has recently observed a new trend of studies orientated towards the misuse of reviews. This quality meta-review intends to summarize the results of all systematic reviews and meta-analyses that have been published on MRONJ in relation to genetic and pharmacogenomics risk factors. Methods: The research study protocol was registered into the database of the International Network for the Registration of Systematic Reviews and Meta-Analyses (INPLASY) INPLASY202230002. A comprehensive search across several databases (PubMed, EMBASE, MEDLINE, and CINAHL) was conducted to locate multi-language papers published between January 2003 and November 2022. Data were collected from relevant research studies and appraised in accordance with the precise outcomes described in this evaluation. Results: Only five systematic reviews and meta-analyses were analysed in this meta-review. All the reviews included in this research presented qualities mistakes and shortcomings. Two quality assessment tools (Confidence in Evidence from Reviews of Qualitative research (CERQual) and Assessment of Multiple Systematic Reviews 2 (AMSTAR-2)) were used to evaluate each study included in this research. Conclusions: The data evaluated by this meta-review confirmed the poor-quality secondary research underpinning the genetic/pharmacogenomics aspect of MRONJ. Moreover, this study highlighted the many flaws of the current published systematic and meta-analysis studies published so far. Full article
(This article belongs to the Special Issue Oral Bone Disease and Bone Regenerative Therapy for Dental Implants)
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20 pages, 3287 KiB  
Review
18 Years of Medication-Related Osteonecrosis of the Jaw (MRONJ) Research: Where Are We Now?—An Umbrella Review
by Roberto Sacco, Monica Diuana Calasans-Maia, Julian Woolley, Oladapo Akintola, Carlos Fernando de Almeida Barros Mourão, Vittorio Moraschini, Evgeny Kushnerev, Alessandro Acocella, Olamide Obisesan and Julian Yates
Appl. Sci. 2021, 11(19), 8818; https://0-doi-org.brum.beds.ac.uk/10.3390/app11198818 - 23 Sep 2021
Cited by 4 | Viewed by 2491
Abstract
Background: Osteonecrosis of the jaw (ONJ) is a condition affecting patients exposed to medications used to treat benign and malignant conditions of bone tissue. Many studies have highlighted that ONJ is a severe condition, which is very challenging to manage, especially in [...] Read more.
Background: Osteonecrosis of the jaw (ONJ) is a condition affecting patients exposed to medications used to treat benign and malignant conditions of bone tissue. Many studies have highlighted that ONJ is a severe condition, which is very challenging to manage, especially in individuals with oncologic disease. The aim of this umbrella review is to analyze all available interventional and non-interventional systematic reviews published on medication-related osteonecrosis of the jaw (MRONJ) and summarize this evidence. Material and methods: A multi-database search (PubMed, MEDLINE, EMBASE and CINAHL) was performed to identify related multi-language papers published from January 2003 until June 2021. An additional manual search was also performed in systematic review registries (PROSPERO, INPLASY, JBI and OFS) to identify possible missing reviews. Data were extracted from relevant papers and analyzed according to the outcomes selected in this review. Results: The search generated 25 systematic reviews eligible for the analysis. The total number of patients included in the analysis was 80,840. Of the reviews, 64% (n = 16) were non-interventional and 36% (n = 9) were interventional. Study designs included case series 20.50% (n = 140), retrospective cohort studies 12.30% (n = 84) and case reports 12.20% (n = 83). It was unclear what study design was used for 277 studies included in the 25 systematic reviews. Conclusions: The data reviewed confirmed that the knowledge underpinning MRONJ in the last 20 years is still based on weak evidence. This umbrella review highlighted a widespread low-level quality of studies and many poorly designed reviews. Full article
(This article belongs to the Special Issue Oral Bone Disease and Bone Regenerative Therapy for Dental Implants)
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Other

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9 pages, 3183 KiB  
Case Report
A Multidisciplinary Pathway for the Diagnosis and Prosthodontic Management of a Patient with Medication-Related Osteonecrosis of the Jaw (MRONJ)
by Amr S. Bugshan and Yousif A. Al-Dulaijan
Appl. Sci. 2022, 12(16), 8202; https://0-doi-org.brum.beds.ac.uk/10.3390/app12168202 - 17 Aug 2022
Cited by 1 | Viewed by 1399
Abstract
Background: Medication-Related Osteonecrosis of the Jaw (MRONJ) can occur as an adverse reaction to several antiresorptive medications such as bisphosphonate. It presents clinically as a necrotic exposed bone. Several factors including tooth extraction and ill-fitting dentures increase the risk of osteonecrosis development. Case [...] Read more.
Background: Medication-Related Osteonecrosis of the Jaw (MRONJ) can occur as an adverse reaction to several antiresorptive medications such as bisphosphonate. It presents clinically as a necrotic exposed bone. Several factors including tooth extraction and ill-fitting dentures increase the risk of osteonecrosis development. Case Report: A 72-year-old female who had an ill-fitting partial denture that caused an exposed necrotic bone and traumatic ulcer on the left posterior mandible. Bony sequestrums were removed and submitted for histological examination, which confirmed the diagnosis of MRONJ. Conclusions: This case illustrates the importance of identifying all risk factors associated with MRONJ by dentists to reduce its development in patients receiving antiresorptive medications. Moreover, patients at risk of MRONJ development should be screened carefully on a regular basis and all dental risk factors should be adjusted or removed. Full article
(This article belongs to the Special Issue Oral Bone Disease and Bone Regenerative Therapy for Dental Implants)
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9 pages, 1413 KiB  
Case Report
Prevention of Mandible Fractures in Medication-Related Osteonecrosis of the Jaws: The Role of Virtual Surgical Planning and Computer-Aided Design and Manufacturing in Two Clinical Case Reports
by João André Correia, José Ricardo Ferreira, Miguel Amaral Nunes, António Capelo, Miguel de Araújo Nobre and Francisco Salvado
Appl. Sci. 2021, 11(17), 7894; https://0-doi-org.brum.beds.ac.uk/10.3390/app11177894 - 26 Aug 2021
Cited by 1 | Viewed by 2401
Abstract
Background: Marginal mandible resection is required to achieve healing in some cases of medication-related osteonecrosis of the jaws (MRONJ). Despite the sparsity of the literature, computer-aided design/computer-aided manufacturing (CAD/CAM) materials may provide superior outcomes for patients with an increased risk of mandible fracture. [...] Read more.
Background: Marginal mandible resection is required to achieve healing in some cases of medication-related osteonecrosis of the jaws (MRONJ). Despite the sparsity of the literature, computer-aided design/computer-aided manufacturing (CAD/CAM) materials may provide superior outcomes for patients with an increased risk of mandible fracture. The aim of this study was to report a digital workflow for surgical interventions to prevent mandible fracture in MRONJ patients. Methods: We present two cases in which virtual surgical planning (VSP) and CAD/CAM surgical guides and reconstruction plates were used to prevent mandible fractures in elderly MRONJ patients submitted for marginal resection. Two osteoporotic patients, aged 73 and 84 years, presented with stage 3 MRONJ of the right mandibular body with inferior alveolar nerve involvement. The unaffected bone height was 6 mm in both cases, implying a high risk of mandible fracture. After preoperative VSP, surgery was performed through a combined intraoral–transbuccal approach. CAD/CAM-customized cutting guides and reconstruction plates were used for the marginal resection of necrotic bone and internal fixation. Results: Complete healing was achieved and the patients remained asymptomatic up to 1 year post-surgery. Conclusions: VSP and CAD/CAM-customized materials facilitated the complete resection of necrotic bone and rigid fixation in MRONJ patients, allowing a simplified approach with shorter operative times, reduced morbidity, and predictable results. Full article
(This article belongs to the Special Issue Oral Bone Disease and Bone Regenerative Therapy for Dental Implants)
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