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Special Issue Editors

Special Issue Information

Dear Colleagues,

Organic chemistry has a central role in chemistry. Advances in organic chemistry boost progress in many other areas of science; this field of chemistry, in particular, enables novel entities to be synthesized, novel properties to be designed and novel processes to be devised. This Special Issue acknowledges the many interfaces of organic chemistry alongside other scientific fields by accepting contributions in a broad range of areas that develop, expand and/or apply concepts from organic chemistry to enable innovation. Both original research and review articles highlighting the contributions of organic chemistry will be considered in the following topics:

Organic synthesis;
Synthetic methodologies;
Green chemistry;
Flow chemistry;
Catalysis;
Reaction mechanism (including theoretical studies);
Physical organic chemistry;
Agro-/medicinal chemistry;
Bioorganic chemistry;
Natural products;
Organic/hybrid materials.

Dr. Francisco de Azambuja
Prof. Dr. Mark P. Farrell
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

organic synthesis
synthetic methodologies
homogeneous catalysis
heterogeneous catalysis
reaction mechanism
DFT
physical organic chemistry
flow chemistry
medicinal chemistry
agricultural chemistry
bioorganic chemistry
natural products
organic/hybrid materials
green chemistry

Published Papers (2 papers)

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Research

Jump to: Review

15 pages, 6614 KiB

Open AccessArticle

Nanostructured Na₂CaP₂O₇: A New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity

by Redouane Achagar, Abdelhakim Elmakssoudi, Abderrahmane Thoume, Mohamed Dakir, Abdelaziz Elamrani, Yassine Zouheir, Mohamed Zahouily, Zouhair Ait-Touchente, Jamal Jamaleddine and Mohamed M. Chehimi

Appl. Sci. 2022, 12(11), 5487; https://0-doi-org.brum.beds.ac.uk/10.3390/app12115487 - 28 May 2022

Cited by 8 | Viewed by 1955

Abstract

A facile and novel synthesis of thirteen 2-amino-3-cyanopyridine derivatives 5(a–m) by a one-pot multicomponent reactions (MCRs) is described for the first time, starting from aromatic aldehydes, malononitrile, methyl ketones, or cyclohexanone and ammonium acetate in the presence of the nanostructured diphosphate Na₂CaP₂O₇ (DIPH) at 80 °C under solvent-free conditions. These compounds were brought into existence in a short period with good to outstanding yields (84–94%). The diphosphate Na₂CaP₂O₇ was synthesized and characterized by different techniques (FT-IR, XRD, SEM, and TEM) and used as an efficient, environmentally friendly, easy-to-handle, harmless, secure, and reusable catalyst. Our study was strengthened by combining five new pyrido[2,3-d]pyrimidine derivatives 6(b, c, g, h, j) by intermolecular cyclization of 2-amino-3-cyanopyridines 5(b, c, g, h, j) with formamide. The synthesized products were characterized by FT-IR, ¹H NMR, and ¹³C NMR and by comparing measured melting points with known values reported in the literature. Gas chromatography/mass spectrometry was used to characterize the newly synthesized products and evaluate their purity. The operating conditions were optimized using a model reaction in which the catalyst amount, temperature, time, and solvent effect were evaluated. Antibacterial activity was tested against approved Gram-positive and Gram-negative strains for previously mentioned compounds. Full article

(This article belongs to the Special Issue Advances in Organic Chemistry: Synthesis, Bioorganic, Medicinal and Materials Chemistry)

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Graphical abstract

Review

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56 pages, 22256 KiB

Open AccessReview

Five-Membered Cyclic Carbonates: Versatility for Applications in Organic Synthesis, Pharmaceutical, and Materials Sciences

by Patrick Rollin, Liane K. Soares, Angelita M. Barcellos, Daniela R. Araujo, Eder J. Lenardão, Raquel G. Jacob and Gelson Perin

Appl. Sci. 2021, 11(11), 5024; https://0-doi-org.brum.beds.ac.uk/10.3390/app11115024 - 29 May 2021

Cited by 39 | Viewed by 8305

Abstract

This review presents the recent advances involving several applications of five-membered cyclic carbonates and derivatives. With more than 150 references, it covers the period from 2012 to 2020, with special emphasis on the use of five-membered cyclic carbonates as building blocks for organic synthesis and material elaboration. We demonstrate the application of cyclic carbonates in several important chemical transformations, such as decarboxylation, hydrogenation, and transesterification reactions, among others. The presence of cyclic carbonates in molecules with high biological potential is also displayed, together with the importance of these compounds in the preparation of materials such as urethanes, polyurethanes, and flame retardants. Full article

(This article belongs to the Special Issue Advances in Organic Chemistry: Synthesis, Bioorganic, Medicinal and Materials Chemistry)

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