Dear Colleagues,

Cancer still remains a puzzle with the myriad pieces not fitting to the general picture due to cancer-known heterogeneity not only between cancers of different origin but within the same cancer as well. The development and progression of cancer are highly affected by the environmental cues fostering metabolic reprogramming for the promotion of cancer growth. Numerous factors, including reactive oxygen species (ROS), are contributing to these processes. Not only are ROS known for their detrimental role, governing genetic mutations that can support eventual cancer development, but they can also lead these transformed cells to apoptosis by activating cellular pathways, thus causing cancer growth arrest. Today, increasing perception recognizes ROS as “cellular fate decision regulators”, the generation of which is highly intertwined with the metabolic switches and antioxidative machinery. Cells are thus exploiting their signaling abilities to regulate their own functions or the ones of neighboring cells.

In this Special Issue, we invite original and review papers exploring the role of ROS, the impact of the metabolic reprogramming, and the cellular antioxidative machinery to the cancer growth. Papers highlighting the importance of ROS, metabolism, and antioxidants in anticancer therapy are also highly appreciated.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• reactive oxygen species (ROS)
• cancer
• cell signaling
• metabolic reprogramming
• antioxidants
• nuclear factor erythroid 2-related factor 2 (NRF2)
• anticancer therapy