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Applied Sciences
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Functional Optical Coherence Tomography (OCT) for Biomedical Application
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Functional Optical Coherence Tomography (OCT) for Biomedical Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (25 May 2022) | Viewed by 10229

Special Issue Editor

Prof. Dr. Taeyoon Son

E-Mail Website
Guest Editor
Department of Bioengineering, University of Illinois, Chicago, IL 60612, USA
Interests: development of functional OCT/OCTA for retina imaging; ultra-widefield fundus imaging for retina and choroid; quantitative monitoring of ocular refractive error; deep learning for artery-vein classification in OCTA; super-resolution ophthalmoscopy of photoreceptors

Special Issue Information

Dear Colleagues,

Optical coherence tomography (OCT) is one of the most powerful non-invasive imaging techniques which enables high-resolution, cross-sectional imaging of biological tissues. As the OCT technique has advanced, OCT can provide functional information, such as cell/tissue physiology, blood flow, and monitoring of disease progress, beyond structural information. These functional extensions of OCT include Doppler OCT, polarization-sensitive OCT, optical coherence elastography, OCT angiography, spectroscopic OCT, optoretinography, and molecular imaging OCT. This development broadens its application across several medical/biomedical fields, such as ophthalmology, dermatology, cardiovascular research, neurology, and small animal imaging. Additionally, various research studies focus on multimodal imaging development with a combination of OCT and other imaging modalities.

This Special Issue, “Functional Optical Coherence Tomography(OCT) for Biomedical Applications”, will highlight research findings and full reviews on the recent development and/or functional application of OCT.

Prof. Dr. Taeyoon Son
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Functional optical coherence tomography
  • Doppler OCT
  • Polarization-sensitive OCT
  • Optical coherence elastography
  • Optical coherence tomography angiography
  • Spectroscopic OCT
  • Optoretinography
  • Optical coherence microscopy

Published Papers (4 papers)

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Research

Jump to: Review

10 pages, 2092 KiB  
Article
Trabecular Meshwork Motion Profile from Pulsatile Pressure Transients: A New Platform to Simulate Transitory Responses in Humans and Nonhuman Primates
by Chen Xin, Xiaofei Wang, Ningli Wang, Ruikang Wang and Murray Johnstone
Appl. Sci. 2022, 12(1), 11; https://0-doi-org.brum.beds.ac.uk/10.3390/app12010011 - 21 Dec 2021
Cited by 9 | Viewed by 2189
Abstract
Trabecular meshwork (TM) motion abnormality is the leading cause of glaucoma. With technique limitations, how TM moves is still an enigma. This study describes a new laboratory platform to investigate TM motion responses to ocular transients in ex vivo eyes. The anterior segments [...] Read more.
Trabecular meshwork (TM) motion abnormality is the leading cause of glaucoma. With technique limitations, how TM moves is still an enigma. This study describes a new laboratory platform to investigate TM motion responses to ocular transients in ex vivo eyes. The anterior segments of human cadaver and primate eyes were mounted in a perfusion system fitting. Perfusion needles were placed to establish mean baseline pressure. A perfusion pump was connected to the posterior chamber and generated an immediate transient pressure elevation. A phase-sensitive optical coherent tomography system imaged and quantified the TM motion. The peak-to-peak TM displacements (ppTMD) were determined, a tissue relaxation curve derived, and a time constant obtained. This study showed that the ppTMD increased with a rise in the pulse amplitude. The ppTMD was highest for the lowest mean pressure of 16 mmHg and decreased with mean pressure increase. The pulse frequency did not significantly change ppTMD. With a fixed pulse amplitude, an increase in mean pressure significantly reduced the time constant of recoil from maximum distension. Our research platform permitted quantitation of TM motion responses to designed pulse transients. Our findings may improve the interpretation of new TM motion measurements in clinic, aiding in understanding mechanisms and management. Full article
(This article belongs to the Special Issue Functional Optical Coherence Tomography (OCT) for Biomedical Application)
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9 pages, 741 KiB  
Article
Effects of Hydroxychloroquine on Retinal Vessel Density in Patients with Rheumatoid Arthritis over One-Year Follow-Up: A Pilot Study
by Pierluigi Iacono, Stefano Da Pozzo, Alberto Bedendo, Monica Varano and Mariacristina Parravano
Appl. Sci. 2021, 11(21), 9837; https://0-doi-org.brum.beds.ac.uk/10.3390/app11219837 - 21 Oct 2021
Viewed by 1146
Abstract
Background: To employ optical coherence tomography angiography (OCTA) to evaluate the effects of hydroxychloroquine (HCQ) on the superficial capillary plexus (SCP) and deep retinal capillary plexus (DCP) in patients affected by rheumatoid arthritis (RA). Methods: Patients with recent diagnosis of “definite RA”, based [...] Read more.
Background: To employ optical coherence tomography angiography (OCTA) to evaluate the effects of hydroxychloroquine (HCQ) on the superficial capillary plexus (SCP) and deep retinal capillary plexus (DCP) in patients affected by rheumatoid arthritis (RA). Methods: Patients with recent diagnosis of “definite RA”, based on 2010 Rheumatoid Arthritis Classification Criteria, were included in a prospective, observational imaging study carried out by the G.B. Bietti Foundation between March 2019 and January 2020. Vessel density (VD) of SCP and DCP, central foveal thickness (CFT) and foveal avascular zone (FAZ) values were collected by OCTA. The primary outcome measure was the VD alteration of SCP and DCP in RA-patients after one year of HCQ treatment. Results: OCTA data analysis showed no statistically significant reduction in the mean VD of SCP and DCP, including the mean global area, central subfield, inner ring and temporal, superior, nasal, and inferior sectors, as well as in the mean CFT and FAZ areas. Conclusions: OCTA demonstrated no early change in the VD in the SCP and DCP, in RA-patients after one year of HCQ treatment. A longer monitoring period would more precisely establish the treatment’s effect on the VD and its correlation with HCQ toxicity. Full article
(This article belongs to the Special Issue Functional Optical Coherence Tomography (OCT) for Biomedical Application)
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Review

Jump to: Research

28 pages, 4004 KiB  
Review
Automatic Segmentation and Classification Methods Using Optical Coherence Tomography Angiography (OCTA): A Review and Handbook
by Kristen M. Meiburger, Massimo Salvi, Giulia Rotunno, Wolfgang Drexler and Mengyang Liu
Appl. Sci. 2021, 11(20), 9734; https://0-doi-org.brum.beds.ac.uk/10.3390/app11209734 - 18 Oct 2021
Cited by 6 | Viewed by 3915
Abstract
Optical coherence tomography angiography (OCTA) is a promising technology for the non-invasive imaging of vasculature. Many studies in literature present automated algorithms to quantify OCTA images, but there is a lack of a review on the most common methods and their comparison considering [...] Read more.
Optical coherence tomography angiography (OCTA) is a promising technology for the non-invasive imaging of vasculature. Many studies in literature present automated algorithms to quantify OCTA images, but there is a lack of a review on the most common methods and their comparison considering multiple clinical applications (e.g., ophthalmology and dermatology). Here, we aim to provide readers with a useful review and handbook for automatic segmentation and classification methods using OCTA images, presenting a comparison of techniques found in the literature based on the adopted segmentation or classification method and on the clinical application. Another goal of this study is to provide insight into the direction of research in automated OCTA image analysis, especially in the current era of deep learning. Full article
(This article belongs to the Special Issue Functional Optical Coherence Tomography (OCT) for Biomedical Application)
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18 pages, 7345 KiB  
Review
Doppler Optical Coherence Tomography for Otology Applications: From Phantom Simulation to In Vivo Experiment
by Daewoon Seong, Changho Lee, Mansik Jeon and Jeehyun Kim
Appl. Sci. 2021, 11(12), 5711; https://0-doi-org.brum.beds.ac.uk/10.3390/app11125711 - 20 Jun 2021
Cited by 5 | Viewed by 2230
Abstract
In otology, visualization and vibratory analysis have been crucial to enhance the success of diagnosis and surgical operation. Optical coherence tomography (OCT) has been employed in otology to obtain morphological structure of tissues non-invasively, owing to the ability of measuring the entire region [...] Read more.
In otology, visualization and vibratory analysis have been crucial to enhance the success of diagnosis and surgical operation. Optical coherence tomography (OCT) has been employed in otology to obtain morphological structure of tissues non-invasively, owing to the ability of measuring the entire region of tympanic membrane, which compensates the limitations of conventional methods. As a functional extension of OCT, Doppler OCT, which enables the measurement of the motion information with structural data of tissue, has been applied in otology. Over the years, Doppler OCT systems have been evolved in various forms to enhance the measuring sensitivity of phase difference. In this review, we provide representative algorithms of Doppler OCT and various applications in otology from preclinical analysis to clinical experiments and discuss future developments. Full article
(This article belongs to the Special Issue Functional Optical Coherence Tomography (OCT) for Biomedical Application)
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