Microfluidic Biochips and Biosensors

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 4257

Special Issue Editors


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Guest Editor
1. Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy
2. INTA srl, Intelligent Acoustics Systems, Via Nino Pisano 14, 56122 Pisa, Italy
Interests: biosensors; microfluidics; surface acoustic waves; micro/nano fabrication; surface functionalization

E-Mail Website
Guest Editor
1. Laboratorio NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy
2. INTA srl, Intelligent Acoustics Systems, Via Nino Pisano 14, 56122 Pisa, Italy
Interests: nanostructured biomaterials for brain pathologies and nerve regeneration; designing, production and testing of surface-acoustic-wave-driven microfluidic devices for lab-on-chip and biosensing applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to submit your latest work to the Special Issue “Microfluidic Biochips and Biosensors" of Applied Sciences (IF 2.474) MDPI. This Special Issue will cover novel microfluidic devices and biosensors for several applications (e.g., life-science, environmental monitoring, food control, and security). The key aspects that will be covered are as follows: liquid manipulation on the nano/microscale, on-chip sample preparation, novel biosensor technology, advanced materials, and devices and fabrication techniques for the sensitive and selective detection of bio-analytes (e.g., protein, nucleic acids, virus, and bacteria). Experimental and theoretical and numerical works involving these topics are welcome.

Dr. Matteo Agostini
Dr. Marco Cecchini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • biosensor
  • lab-on-a-chip
  • biochip

Published Papers (1 paper)

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Research

18 pages, 3187 KiB  
Article
Blood–Brain Barrier Dynamic Device with Uniform Shear Stress Distribution for Microscopy and Permeability Measurements
by Nina Choublier, Yoann Müller, Loris Gomez Baisac, Jeremy Laedermann, Casimir de Rham, Xavier Declèves and Adrien Roux
Appl. Sci. 2021, 11(12), 5584; https://0-doi-org.brum.beds.ac.uk/10.3390/app11125584 - 16 Jun 2021
Cited by 8 | Viewed by 3611
Abstract
Neurology has always been one of the therapeutic areas with higher attrition rates. One of the main difficulties is the presence of the blood–brain barrier (BBB) that restricts access to the brain for major drugs. This low success rate has led to an [...] Read more.
Neurology has always been one of the therapeutic areas with higher attrition rates. One of the main difficulties is the presence of the blood–brain barrier (BBB) that restricts access to the brain for major drugs. This low success rate has led to an increasing demand for in vitro tools. The shear stress, which positively affects endothelial cell differentiation by mimicking blood flow, is required for a more physiological in vitro BBB model. We created an innovative device specifically designed for cell culture under shear stress to investigate drug permeability. Our dynamic device encompasses two compartments communicating together via a semi-permeable membrane, on which human cerebral microvascular endothelial (hCMEC/D3) cells were seeded. The fluidic controlled environment ensures a laminar and homogenous flow to culture cells for at least seven days. Cell differentiation was characterized by immunodetection of inter-endothelial junctions directly in the device by confocal microscopy. Finally, we performed permeability assay with lucifer yellow in both static and dynamic conditions in parallel. Our dynamic device is suited to the evaluation of barrier function and the study of drug transport across the BBB, but it could also be used with other human cell types to reproduce intestinal or kidney barriers. Full article
(This article belongs to the Special Issue Microfluidic Biochips and Biosensors)
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