3D Cell Culture Model and System Imaging for in vitro Disease Modeling

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 418

Special Issue Editors

Biopharmaceuticals R&D Cardiovascular, Renal and Metabolism, AstraZeneca, Gothenburg, Sweden
Interests: 3D cell culture; organoids; enteroids; biomaterials; tissue engineering; hydrogel; drug discovery; bioimaging; cardio-renal; metabolic disease; stem cell
Laboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Interests: immuno-mechanobiology; biomaterials; biomimetic in vitro system; bioartificial organs

Special Issue Information

Dear Colleagues,

3D cell culture models have broadened the application of in vitro experiments by allowing mimicry of human and animal organs. The study of the physiological functions of organ mimics helps us to understand disease mechanisms in the laboratory thus making conventional in vitro disease modeling outdated. By carefully designing and evaluating cellular composition, cellular niches, and cues presentation in 3D organ models and by using appropriate imaging techniques, it becomes possible to decipher disease mechanisms and envisage therapeutic interventions.

Recent studies have demonstrated the potential of combining complex 3D cell culture models, cellular or molecular cloning, and advanced imaging to comprehensively understand various mammalian diseases. From the pharmaceutical industry perspective, this strategy can effectively reduce costly animal models, thus upholding the 3R principles.

This Special Issue on 3D cell culture model and system imaging for in vitro disease modeling will present original research papers and comprehensive reviews dealing with cutting-edge experimental methodologies for in vitro disease modeling.

Topics of interest to this Special Issue include, but are not limited to, the following:

  1. In vitro engineered complex tissues to monitor disease progression and interventions
  2. Image-based analysis using a combination of in vitro engineered complex tissues and cellular reporters
  3. Compounds evaluation in 3D cell culture models with image analysis
  4. Multi-organ in vitro 3D culture 

Dr. Bramasta Nugraha
Prof. Jeremy Teo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D cell culture
  • system imaging
  • advanced microscopy
  • high-throughput imaging
  • image-based analysis
  • disease modeling
  • artificial organs

Published Papers

There is no accepted submissions to this special issue at this moment.
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